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001-es BibID:BIBFORM010290
035-os BibID:PMID:19590037
Első szerző:Péterfi Zalán
Cím:Peroxidasin is secreted and incorporated into the extracellular matrix of myofibroblasts and fibrotic kidney / Péterfi Zalán, Donkó Ágnes, Orient Anna, Sum Adrienn, Prokai Ágnes, Molnár Beáta, Veréb Zoltán, Rajnavölgyi Éva, Kovács Krisztina, Müller Veronika, Szabó Attila J., Geiszt Miklós
Dátum:2009
Megjegyzések:Mammalian peroxidases are heme-containing enzymes that serve diverse biological roles, such as host defense and hormone biosynthesis. A mammalian homolog of Drosophila peroxidasin belongs to the peroxidase family; however, its function is currently unknown. in this study, we show that peroxidasin is present in the endoplasmic reticulum of human primary pulmonary and dermal fibroblasts, and the expression of this protein is increased during transforming growth factor-beta 1-induced myofibroblast differentiation. Myofibroblasts secrete peroxidasin into the extracellular space where it becomes organized into a fibril-like network and colocalizes with fibronectin, thus helping to form the extracellular matrix. We also demonstrate that peroxidasin expression is increased in a murine model of kidney fibrosis and that peroxidasin localizes to the peritubular space in fibrotic kidneys. in addition, we show that this novel pathway of extracellular matrix formation is unlikely mediated by the peroxidase activity of the protein. Our data indicate that peroxidasin secretion represents a previously unknown pathway in extracellular matrix formation with a potentially important role in the physiological and pathological fibrogenic response.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The American Journal of Pathology. - 175 : 2 (2009), p. 725-735. -
További szerzők:Donkó Ágnes Orient Anna Sum Adrienn Prokai Ágnes Molnár Beáta Veréb Zoltán (1980-) (immunológus, mikrobiológus, molekuláris biológus) Rajnavölgyi Éva (1950-) (immunológus) Kovács Krisztina Müller Veronika Szabó Attila (gyermekgyógyász Budapest) Geiszt Miklós
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