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1.

001-es BibID:BIBFORM003468
Első szerző:Asztalos László (sebész)
Cím:Renal Artery Aneurysm at the Anastomosis After Kidney Transplantation / L. Asztalos, S. Olvasztó, R. Fedor, L. Szabó, G. Balázs, G. Lukács
Dátum:2006
Megjegyzések:Vascular complications represent serious problems after kidney transplantation. An aneurysm of the transplanted renal artery is an extremely rare but potentially devastating complication that which occurs in fewer than 1% of recipients. It can cause hypertension, functional impairment, and even graft loss. A 49-year-old man was admitted 6 months after his second renal transplantation. Duplex ultrasonography demonstrated an aneurysm at the anastomosis of the transplanted renal artery. The patient has not had any complaints. The function of the graft was stable. A computed tomography scan confirmed the diagnosis. Because of the high risk of rupture we decided upon surgical repair. During the operation, blood flow to the kidney was occluded; the graft was cooled with Euro-Collin's solution and ice-cold saline. After the resection there was enough usable arterial wall to construct a new anastomosis. The patient had an uneventful postoperative period, the serum creatinine decreased to the preoperative level, and the function of the graft was stable. Renal artery aneurysms represent high-risk complications. We decided on surgical repair, which was performed with simultaneous perfusion and cooling -of the graft. There are only a few similar cases in the literature; it was the first operation using this method in our practice. Surgical reconstruction of a renal artery aneurysm, if feasible, is a safe procedure that prevents aneurysm rupture and saves the graft.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Transplantation Proceedings. - 38 : 9 (2006), p. 2915-2918. -
További szerzők:Olvasztó Sándor (1957-) (sebész) Fedor Roland (1975-) (sebész) Szabó László (1975-) (sebész) Balázs György (1933-) (sebész) Lukács Géza (1941-) (sebész)
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2.

001-es BibID:BIBFORM038178
Első szerző:Fedor Roland (sebész)
Cím:Insertion/deletion polymorphism of the angiotensin-converting enzyme predicts left ventricular hypertrophy after renal transplantation / Fedor R., Asztalos L., Locsey L., Szabó L., Mányiné I. S., Fagyas M., Lizanecz E., Tóth A.
Dátum:2011
ISSN:0041-1345
Megjegyzések:Kidney transplant recipients show a higher risk for cardiovascular complications, such as left ventricular hypertrophy and heart failure, leading to the premature death in many cases. METHODS: We investigated the contribution of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism to the development of left ventricular hypertrophy (LVH), an indicator of heart disease progression among kidney transplant recipients. RESULTS: We observed a significant correlation between graft function and left ventricular mass index. The occurrence of LVH or severe LVH was significantly greater among patients with at least one D-allele (ID or DD). CONCLUSION: The use of ACE inhibitors or angiotensin receptor blockers seemed to be advantageous for patients with the ID and especially, the DD genotype.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Transplantation Proceedings. - 43 : 4 (2011), p. 1259-1260. -
További szerzők:Asztalos László (1951-) (sebész) Lőcsey Lajos (1946-2013) (belgyógyász, nephrológus) Szabó László (1975-) (sebész) Mányiné Siket Ivetta (1962-) (laborasszisztens) Fagyas Miklós (1984-) (orvos) Lizanecz Erzsébet (1978-) (orvos) Tóth Attila (1971-) (biológus)
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3.

001-es BibID:BIBFORM038177
Első szerző:Fedor Roland (sebész)
Cím:Insertion/Deletion polymorphism of angiotensin-converting enzyme as a risk factor for chronic allograft nephropathy / Fedor R., Asztalos L., Löcsey L., Szabó L., Mányiné I. S., Fagyas M., Lizanecz E., Tóth A.
Dátum:2010
ISSN:0041-1345
Megjegyzések:Angiotensin-converting enzyme (ACE) inhibitor therapy is widely used to treat chronicallograft nephropathy (CAN), which suggests a possible role of the renin-angiotensin system inthe pathologic mechanism of the disease. The objective of this study was to investigate thepossible link between CAN and ACE. The ACE insertion/deletion polymorphism and theamount and activity of ACE were determined in cadaver kidney recipients with CAN (n - 38)or normal renal function (n - 34). The DD genotype was observed significantly morefrequently in the CAN group compared with the group with normal renal function. Moreover,the DD genotype was associated with a higher serum ACE concentration and greater serumACE activity, compared with II genotype homozygotes. The insertion/deletion polymorphismof ACE affects ACE expression and activity in serum, and, therefore, may have an importantrole in the pathogenesis of CAN. These findings suggest that determination of the ACEgenotype may be useful in identifying patients at high risk. In particular, the DD genotype maybe considered an indication for ACE inhibitor therapy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekuláris Medicina
Megjelenés:Transplantation Proceedings. - 42 : 6 (2010), p. 2304-2308. -
További szerzők:Asztalos László (1951-) (sebész) Lőcsey Lajos (1946-2013) (belgyógyász, nephrológus) Szabó László (1975-) (sebész) Mányiné Siket Ivetta (1962-) (laborasszisztens) Fagyas Miklós (1984-) (orvos) Lizanecz Erzsébet (1978-) (orvos) Tóth Attila (1971-) (biológus)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Kardiológia, klinikai fiziológia
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4.

001-es BibID:BIBFORM105891
035-os BibID:(WOS)000911722700001 (Scopus)85141973908
Első szerző:Illésy Lóránt (sebész)
Cím:Ureteral Complications Requiring Intervention After Kidney Transplant : A Single-Center Experience / Illésy Lóránt, Kovács Dávid Ágoston, Fedor Roland, Zádori Gergely, Kanyári Zsolt, Asztalos László, Nemes Balázs
Dátum:2022
ISSN:0041-1345
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Transplantation Proceedings. - 54 : 9 (2022), p. 2578-2583. -
További szerzők:Kovács Dávid Ágoston (1982-) (sebész) Fedor Roland (1975-) (sebész) Zádori Gergely (1983-) (sebész) Kanyári Zsolt (1964-) (orvos) Asztalos László (1951-) (sebész) Nemes Balázs Áron (1969-) (sebész)
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5.

001-es BibID:BIBFORM078819
035-os BibID:(WoS)000500179300060 (Scopus)85065483146
Első szerző:Illésy Lóránt (sebész)
Cím:Non-Hodgkin Lymphoma in a Kidney Transplant Patient : a Case Report / Lóránt Illésy, Réka P. Szabó, Dávid Ágoston Kovács, Roland Fedor, Balázs Nemes
Dátum:2019
ISSN:0041-1345
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Transplantation Proceedings. - 51 : 4 (2019), p. 1286-1288. -
További szerzők:P. Szabó Réka (1979-) (orvos) Kovács Dávid Ágoston (1982-) (sebész) Fedor Roland (1975-) (sebész) Nemes Balázs Áron (1969-) (sebész)
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6.

001-es BibID:BIBFORM073245
035-os BibID:(WoS)000386317900073 (Scopus)84992391414
Első szerző:Illésy Lóránt (sebész)
Cím:Bacterial Infections After Kidney Transplantation : a Single-Center Experience / L. Illesy, M. Szabo-Pap, F. Toth, G. Zadori, L. Zsom, L. Asztalos, R. P. Szabo, R. Fedor, B. Nemes
Dátum:2016
ISSN:0041-1345
Megjegyzések:Bacterial infections significantly affect graft loss and mortality after kidney transplantation (KT). We reviewed the frequencies, risk factors, and sources of bacterial infections after KT and their impact on graft and patient survivals. METHODS: The data of 154 kidney recipients who underwent transplantation from 2010 to 2015 were explored. Donor, recipient, and surgical parameters were collected, and source, type, and frequency of infectious complications, number of infective episodes, multidrug-resistant (MDR) bacteria, and the bacterial spectrum were established. RESULTS: The most common infection was urinary tract infection, which is in line with the literature. Out of the 154 recipients, 72.1% (n = 111) had at least 1 occasion of a bacterial infection episode with clinical symptoms. It occurred 0-43 months (mean, 19.5 mo) after transplantation. Ninety-three KT recipients (67.9%) developed 274 episodes of infection in the postoperative 1st year (1.8 episodes/patient/y), and 42 patients had admission to the hospital ward (5.2 d/patient/y). MDR was detected in 19.8% of the infections. CONCLUSIONS: A bacterial infection had no significant impact on survival by itself. However, in case of sepsis graft and patient survivals were lower compared with normal control subjects.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Transplantation Proceedings. - 48 : 7 (2016), p. 2540-2543. -
További szerzők:Szabó-Pap Marcell Tóth F. Zádori Gergely (1983-) (sebész) Zsom Lajos (1968-) (belgyógyász, nefrológus) Asztalos László (1951-) (sebész) P. Szabó Réka (1979-) (orvos) Fedor Roland (1975-) (sebész) Nemes Balázs Áron (1969-) (sebész)
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7.

001-es BibID:BIBFORM079170
035-os BibID:(WoS)000500179300051 (Scopus)85065488320
Első szerző:Kovács Dávid Ágoston (sebész)
Cím:Surgical Treatment of Hyperparathyroidism After Kidney Transplant / D. Á. Kovács, R. Fedor, L. Asztalos, M. Andrási, R. P. Szabó, Zs. Kanyári, S. Barna, B. Nemes, F. Győry
Dátum:2019
ISSN:0041-1345
Megjegyzések: Chronic renal impairment is often associated with complex bone disorders. Improvement of secondary hyperparathyroidism (HPT) is expected after kidney transplant (KT) if the glomerular filtration rate is normalized. Patients and Methods There were 888 KTs performed between 1996 and 2017 at our department. A total of 558 general patients have been operated on for HPT during the same period. The 2 populations had a common part: out of the 558, a total of 69 (12.4%) were in end-stage renal failure when operated on because of secondary HPT. That also means that 7.8% of all KTs were associated with HPT. Retrospective, single-center analysis was performed using the patients' medical records. The aim of our study was to analyze the results of parathyroidectomies after KT. Results Parathyroid surgery was performed on 19 patients (2.14%) because of HPT after KT. The applied surgical technique was total parathyroidectomy with autotransplant in 6 cases, subtotal parathyroidectomy in 3 cases, and selective parathyroidectomy in 10 cases. In all cases, histology revealed benign disease. Complications were observed in 10 cases (52%); there were 6 cases of postoperative hypocalcaemia (31.58%), 1 case of transient laryngeal recurrent nerve paresis (5.26%), and 6 cases of recurrent HPT (31.58%). Summary The first step of HPT management is calcimimetic drug treatment. It is essential to prevent possible complications with regular laboratory monitoring. If the proper conservative therapy is refractory or severe in complications, surgery should be chosen. If the patient is already waiting for a KT, it is worth performing the parathyroid surgery before KT. Close collaboration with endocrinologists and nephrologists is needed to achieve successful therapy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok konferenciacikk
folyóiratcikk
hyperparathyroidisim
kidney transplant
Megjelenés:Transplantation Proceedings. - 51 : 4 (2019), p. 1244-1247. -
További szerzők:Fedor Roland (1975-) (sebész) Asztalos László (1951-) (sebész) Andrási M. P. Szabó Réka (1979-) (orvos) Kanyári Zsolt (1964-) (orvos) Barna Sándor (1982-) (kutató orvos) Nemes Balázs Áron (1969-) (sebész) Győry Ferenc (1964-) (sebész)
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8.

001-es BibID:BIBFORM067491
Első szerző:Kovács Dávid Ágoston (sebész)
Cím:Gerundium : a Comprehensive Public Educational Program on Organ Donation and Transplantation and Civil Law in Hungary / D. Á. Kovács, S. Mihály, K. Rajczy, L. Zsom, G. Zádori, R. Fedor, E. Kaáli, E. Balogh, L. Asztalos, B. Nemes
Dátum:2015
ISSN:0041-1345
Megjegyzések:bstractBACKGROUND:Organ transplantation has become an organized, routine, widely used method in the treatment of several end-stage diseases. Kidney transplantation means the best life-quality and longest life expectancy for patients with end-stage renal diseases. Transplantation is the only available long-term medical treatment for patients with end-stage liver, heart, and lung diseases. Despite the number of transplantations increasing worldwide, the needs of the waiting lists remain below expectations.METHODS:One of the few methods to increase the number of transplantations is public education. In cooperation with the University of Debrecen Institute for Surgery Department of Transplantation, the Hungarian National Blood Transfusion Service Organ Coordination Office, and the Local Committee Debrecen of Hungarian Medical Students' International Relations Committee (HuMSIRC), the Gerundium, a new educational program, has been established to serve this target. Gerundium is a special program designed especially for youth education. Peer education means that age-related medical student volunteers educate their peers during interactive unofficial sessions.RESULTS:Volunteers were trained during specially designed training. Medical students were honored by HuMSIRC, depending on their activity on the basis of their own regulations. Uniform slides and brochures to share were designed. Every Hungarian secondary school was informed. The Local Committee Budapest of HuMSIRC also joined the program, which helps to expand our activity throughout Hungary. The aim of the program is public education to help disperse disapproval, if presented.CONCLUSIONS:As a multiple effect, our program promotes medical students to have better skills in the field of transplantation, presentation, and communication skills. Our program is a voluntary program with strong professional support and is free of charge for the community.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
organ
donation
transplantation
civil
law
hungary
Megjelenés:Transplantation Proceedings 47 : 7 (2015), p. 2186-2188. -
További szerzők:Mihály Sándor Rajczy Katalin Zsom Lajos (1968-) (belgyógyász, nefrológus) Zádori Gergely (1983-) (sebész) Fedor Roland (1975-) (sebész) Kaáli Eszter Balogh Enikő Asztalos László (1951-) (sebész) Nemes Balázs Áron (1969-) (sebész)
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9.

001-es BibID:BIBFORM054356
Első szerző:Kovács Dávid Ágoston (sebész)
Cím:Three-year longitudinal clinical trial of arterial function assessed by a oscillometric non-invasive method in comparison with carotid sclerosis and transferrin kidney-transplanted patients / D. Kovács, L. Lőcsey, R. Laczik, L. Szabó, L. Zsom, K. Kabai, R. Fedor, B. Nemes, L. Asztalos, P. Soltész
Dátum:2014
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Transplantation Proceedings 46 : 6 (2014), p. 2168-2170. -
További szerzők:Lőcsey Lajos (1946-2013) (belgyógyász, nephrológus) Laczik Renáta (1982-) (orvos) Szabó László (1975-) (sebész) Zsom Lajos (1968-) (belgyógyász, nefrológus) Kabai Krisztina Fedor Roland (1975-) (sebész) Nemes Balázs Áron (1969-) (sebész) Asztalos László (1951-) (sebész) Soltész Pál (1961-) (belgyógyász, kardiológus)
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10.

001-es BibID:BIBFORM051725
035-os BibID:PMID:24314996 WOS:000328304700069
Első szerző:Kovács Dávid Ágoston (sebész)
Cím:Noninvasive perioperative monitoring of arterial function in patients with kidney transplantation / D. Kovács, L. Löcsey, L. Szabó, R. Fedor, R. Laczik, L. Asztalos, P. Soltész
Dátum:2013
Megjegyzések:Development of atherosclerosis is accelerated in kidney transplant recipients. Impaired metabolic pathways have a complex effect on the arterial wall, which can be measured by noninvasive techniques. Few data are available on the change of stiffness parameters in the postoperative course, so in this study we analyzed the stiffness parameters of kidney transplant recipients during the perioperative period. Seventeen successful primary kidney transplant patients with uneventful postoperative period (7 woman, 10 men; 46.16 ± 12.19 years) were involved in our short-term prospective longitudinal study. We analyzed the correlation between noninvasively assessed stiffness parameters (pulse wave velocity [PWV], augmentation index [AIx], pulse pressure [PP], systolic area index, diastolic area index, diastolic reflection area), ankle-brachial index (ABI), and laboratory parameters (creatinine, glomerular filtration rate, urea, haemoglobin, C-reactive protein). Stiffness parameters were measured with a Tensiomed Arteriograph. These parameters were assessed before the transplantation, and 24 hours, and 1 and 2 weeks after surgery under standard conditions. We found that creatinine (P = .0008) and C-reactive protein (P = .006) serum levels decreased, and glomerular filtration rate increased significantly (P = .0005). We revealed that PWV (P = .0075) and AIx (P = .013) improved significantly. There was no significant change in ABI, PP, and the other monitored parameters. Along with the available data in the literature, our findings suggest that kidney transplantation has a positive effect on the arterial function.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Transplantation Proceedings 45 : 10 (2013), p. 3682-3684. -
További szerzők:Lőcsey Lajos (1946-2013) (belgyógyász, nephrológus) Szabó László (1975-) (sebész) Fedor Roland (1975-) (sebész) Laczik Renáta (1982-) (orvos) Asztalos László (1951-) (sebész) Soltész Pál (1961-) (belgyógyász, kardiológus)
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11.

001-es BibID:BIBFORM019304
Első szerző:Kovács Dávid Ágoston (sebész)
Cím:Prospective Study of Changes in Arterial Stiffness among Kidney-Transplanted Patients / Kovács, D., Szabó, L., Fedor, R., Laczik, R., Soltész, P., Lőcsey, L., Asztalos, L.
Dátum:2011
ISSN:0041-1345
Megjegyzések:Chronic kidney disease is one of the main risk factors for cardiovascular disease. Changes in stiffness parameters can predict the higher risk of the development of cardiovascular disease. METHODS: Cadaveric donor kidney transplant patients (n=184) were followed in a cross-sectional single-center study. Arterial stiffness parameters were measured by arteriography. We analyzed the correlation between stiffness parameters and immunosuppressive therapy, the main operation parameters, patient age, elapsed time since transplantation, carotid artery stenosis, and septual wall thickness. We enrolled 24 patients in a 3-year longitudinal study to analyze changes in stiffness parameters. RESULTS: Our cross-sectional study showed pulse wave velocity (PWV) to be significantly related to the age of the patient (P=.0001; r=0.41). There was no significant correlation between the stiffness parameters and type or dosage of immunosuppressive drugs and number of transplantations. We noted significant correlations between pulse pressure (PP) and pulse wave velocity (PWV), and augmentation index (AI) (P=.01). Patients with abnormal PWV (>12 m/s) showed significantly higher systolic blood pressures, body mass indexes, PP, and AI (P<.01). Our 3-year longitudinal study revealed a significant elevation in PWV. CONCLUSIONS: Improving endothelial function and prevention of atherosclerosis may help to reduce cardiovascular complications. Among chronic kidney disease patients, early transplantation is a possible way to prevent cardiovascular events. It is better to perform the transplantation at as early an age as possible.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Transplantation Proceedings 43 : 4 (2011), p. 1252-1253. -
További szerzők:Szabó László (1975-) (sebész) Fedor Roland (1975-) (sebész) Laczik Renáta (1982-) (orvos) Soltész Pál (1961-) (belgyógyász, kardiológus) Lőcsey Lajos (1946-2013) (belgyógyász, nephrológus) Asztalos László (1951-) (sebész)
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12.

001-es BibID:BIBFORM049039
035-os BibID:PMID:24314997 WOS:000328304700070
Első szerző:Lőcsey Lajos (belgyógyász, nephrológus)
Cím:Relationship Between Serum Paraoxonase and Homocysteine Thiolactonase Activity, Adipokines, and Asymmetric Dimethyl Arginine Concentrations in Renal Transplant Patients / L. Locsey, I. Seres, F. Sztanek, M. Harangi, J. Padra, D. Kovacs, R. Fedor, L. Asztalos, G. Paragh
Dátum:2013
ISSN:0041-1345
Megjegyzések:Paraoxonase lactonase activity protects against homocysteinylation; therefore, it can be a potential contributing factor to prevent atherosclerosis. We aimed to determine paraoxonase and HTLase activities and to clarify the relationship between HTLase activity and some cardiovascular risk factors, such as homocysteine, cystatin C asymmetric dimethylarginine (ADMA), and adipokines both in hemo dialyzed and transplanted patients. Among 114 hemodialyzed, 80 transplanted and 64 healthy control subjects, we investigated body mass index (BMI) as well as fasting serum contents of urea, uric acid, creatinine, cystatin C, homocysteine, glucose, lipids, total protein and albumin. Serum paraoxonase (PON 1) and HTLase activities were measured spectrophotometrically. ADMA, ADPN adiponectin, leptin (LEP) levels was determined with a sandwich enzyme-linked immunosorbent assay method. Dyslipidemic patients showed hypercholesterolemia, and high low-density lipoprotein (LDL); parallel with improved renal function, they displayed decreased cystatin C and homocysteine levels (P < .001). There was a significant negative correlation between PON 1 activity and cystatin C and homocysteine concentrations (P < .05). Obese patients revealed significantly higher LDL (P < .05) and leptin concentrations (P < .01). There was a significant positive correlation between PON 1 activity and adiponectin levels (P = .0276). Both dialyzed and transplanted patients displayed significantly lower HTLase activities compared to the control group (P < .001), particularly lower HTLase and PON 1 activities in dialyzed subjects compared with the transplanted group (P < .05). HTLase activity showed significant negative correlations with ADMA levels among the whole study population (P < .001), whereas positive associations were noted between PON 1 and HTLase activities (P < .001). HTLase activity may be a new predictor of cardiovascular risk in renal failure although it is modulated by other risk factors.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Transplantation Proceedings. - 45 : 10 (2013), p. 3685-3687. -
További szerzők:Seres Ildikó (1954-) (biokémikus) Sztanek Ferenc (1982-) (orvos) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Padra János Tamás (1984-) (biológus) Kovács Dávid Ágoston (1982-) (sebész) Fedor Roland (1975-) (sebész) Asztalos László (1951-) (sebész) Paragh György (1953-) (belgyógyász)
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