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001-es BibID:	BIBFORM078218
035-os BibID:	(PMID)11172541
Első szerző:	Benoit, Gérard R.
Cím:	Exploring (novel) gene expression during retinoid-induced maturation and cell death of acute promyelocytic leukemia / Gérard R. Benoit, Jien-Hua Tong, Zoltan Balajthy, Michel Lanotte
Dátum:	2001
ISSN:	0037-1963
Megjegyzések:	During recent years, reports have shown that biological responses of acute promyelocytic leukemia (APL) cells to retinoids are more complex than initially envisioned. PML-RARalpha chimeric protein disturbs various biological processes such as cell proliferation, differentiation, and apoptosis. The distinct biological programs that regulate these processes stem from specific transcriptional activation of distinct (but overlapping) sets of genes. These programs are sometimes mutually exclusive and depend on whether the signals are delivered by RAR or RXR agonists. Furthermore, evidence that retinoid nuclear signaling by retinoid, on its own, is not enough to trigger these cellular responses is rapidly accumulating. Indeed, work with NB4 cells show that the fate of APL cells treated by retinoid depends on complex signaling cross-talk. Elucidation of the sequence of events and cascades of transcriptional regulation necessary for APL cell maturation will be an additional tool with which to further improve therapy by retinoids. In this task, the classical techniques used to analyze gene expression have proved time consuming, and their yield has been limited. Global analyses of the APL cell transcriptome are needed. We review the technical approaches currently available (differential display, complementary DNA microarrays), to identify novel genes involved in the determination of cell fate.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Seminars In Hematology. - 38 : 1 (2001), p. 71-85. -
További szerzők:	Tong, Jian-Hua Balajthy Zoltán (1957-) (biokémikus, sejtbiológus) Lanotte, Michel
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM078144
035-os BibID:	(PMID)11435615
Első szerző:	Benoit, Gérard R.
Cím:	Autonomous rexinoid death signaling is suppressed by converging signaling pathways in immature leukemia cells / G. R. Benoit, M. Flexor, F. Besançon, L. Altucci, A. Rossin, J. Hillion, Z. Balajthy, L. Legres, E. Ségal-Bendirdjian, H. Gronemeyer, M. Lanotte
Dátum:	2001
ISSN:	0888-8809
Megjegyzések:	On their own, retinoid X receptor (RXR)-selective ligands (rexinoids) are silent in retinoic acid receptor (RAR)-RXR heterodimers, and no selective rexinoid program has been described as yet in cellular systems. We report here on the rexinoid signaling capacity that triggers apoptosis of immature promyelocytic NB4 cells as a default pathway in the absence of survival factors. Rexinoid-induced apoptosis displays all features of bona fide programmed cell death and is inhibited by RXR, but not RAR antagonists. Several types of survival signals block rexinoid-induced apoptosis. RARalpha agonists switch the cellular response toward differentiation and induce the expression of antiapoptosis factors. Activation of the protein kinase A pathway in the presence of rexinoid agonists induces maturation and blocks immature cell apoptosis. Addition of nonretinoid serum factors also blocks cell death but does not induce cell differentiation. Rexinoid-induced apoptosis is linked to neither the presence nor stability of the promyelocytic leukemia-RARalpha fusion protein and operates also in non-acute promyelocytic leukemia cells. Together our results support a model according to which rexinoids activate in certain leukemia cells a default death pathway onto which several other signaling paradigms converge. This pathway is entirely distinct from that triggered by RAR agonists, which control cell maturation and postmaturation apoptosis.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Molecular Endocrinology. - 15 : 7 (2001), p. 1154-1169. -
További szerzők:	Flexor, M. Besançon, F. Altucci, L. Rossin, Andrea Hillion, Josette Balajthy Zoltán (1957-) (biokémikus, sejtbiológus) Legres, L. Ségal-Bendirdjian, Evelyne Gronemeyer, Hinrich Lanotte, Michel
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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