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001-es BibID:	BIBFORM015750
Első szerző:	Machackova, Jarmila
Cím:	Amelioration of Cardiac Remodeling in Congestive Heart Failure by beta-Adrenoceptor Blockade is Associated with Depression in Sympathetic Activity / Jarmila Machackova, Santosh K. Sanganalmath, Barta Judit, Ken S. Dhalla, Naranjan S. Dhalla
Dátum:	2010
Megjegyzések:	This study investigated whether improvement in cardiac function and attenuation of cardiac remodeling by some b-adrenoceptor (b-AR) antagonists were associated with a depression in sympathetic activity in congestive heart failure (CHF) due to myocardial infarction (MI). Although cardiac dysfunction, hypertrophy and dilatation as well as increased plasma level of catecholamines are known to occur in CHF, the relationship between these parameters is poorly understood. Three weeks after occlusion of the coronary artery, rats were treated daily with 20 and 75 mg/kg of either atenolol or propranolol for 5 weeks. Sham-operated rats served as controls. Both atenolol and propranolol at 20 and 75 mg/kg doses attenuated the MI-induced cardiac hypertrophy, increases in left ventricular (LV) end-diastolic pressure, LV end-systolic volume and LV end-diastolic volume as well as depressions in LV systolic pressure, LV fractional shortening and cardiac output. PR interval was decreased and QTc interval was increased in CHF; these alterations were ameliorated by both atenolol and propranolol. The increased level of plasma epinephrine in CHF was also depressed by both low and high doses of atenolol and propranolol whereas the increased level of plasma norepinephrine was reduced by high but not low doses of these drugs. The results indicate that the beneficial effects of b-AR antagonists on cardiacremodeling and heart dysfunction in CHF may be due tothe blockade of b-ARs in the myocardium and a depressionin the sympathetic activity.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Cardiac dysfunction Plasma catecholamines beta-Adrenoceptor antagonists Cardiac hypertrophy and failure
Megjelenés:	Cardiovascular Toxicology. - 10 : 1 (2010), p. 9-16. -
További szerzők:	Sanganalmath, Santosh K. Barta Judit (1975-) (kardiológus) Dhalla, Ken S. Dhalla, Naranjan S.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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