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001-es BibID:BIBFORM113002
035-os BibID:(cikkazonosító)174 (scopus)85163820798 (wos)001021227100001
Első szerző:Bojti István
Cím:Decreased level of serum NT-proCNP associates with disease severity in COVID-19 / Bojti Istvan, Przewosnik Anne-Sophie, Luxenburger Hendrik, Hofmann Maike, Neumann-Haefelin Christoph, Esser Jennifer S., Siegel Patrick M., Maier Alexander, Kovacs Sarolta Bojtine, Kardos Laszlo, Csanádi Zoltan, Rieder Marina, Duerschmied Daniel, Lother Achim, Bode Christoph, Szabó Gabor Tamas, Czuriga Daniel
Dátum:2023
ISSN:1465-993X
Megjegyzések:Background: C-type natriuretic peptide (CNP) is an endothelium-derived paracrine molecule with an important role in vascular homeostasis. In septic patients, the serum level of the amino-terminal propeptide of CNP (NT-proCNP) shows a strong positive correlation with inflammatory biomarkers and, if elevated, correlates with disease severity and indicates a poor outcome. It is not yet known whether NT-proCNP also correlates with the clinical outcome of patients suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the current study, we aimed to determine possible changes in the NT-proCNP levels of patients with coronavirus disease 2019 (COVID-19), with special regard to disease severity and outcome. Methods: In this retrospective analysis, we determined the serum level of NT-proCNP in hospitalized patients with symptoms of upper respiratory tract infection, using their blood samples taken on admission, stored in a biobank. The NT-proCNP levels of 32 SARS-CoV-2 positive and 35 SARS-CoV-2 negative patients were measured to investigate possible correlation with disease outcome. SARS-CoV-2 positive patients were then divided into two groups based on their need for intensive care unit treatment (severe and mild COVID-19). Results: The NT-proCNP was significantly different in the study groups (e.g. severe and mild COVID-19 and non-COVID-19 patients), but showed inverse changes compared to previous observations in septic patients: lowest levels were detected in critically ill COVID-19 patients, while highest levels in the non-COVID-19 group. A low level of NT-proCNP on admission was significantly associated with severe disease outcome. Conclusions: Low-level NT-proCNP on hospital admission is associated with a severe COVID-19 disease course. The pathomechanism underlying this observation remains to be elucidated, while future studies in larger patient cohorts are necessary to confirm these observations and reveal therapeutic importance.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
COVID-19
Furin
NT-proCNP
SARS-CoV-2
Megjelenés:Respiratory Research. - 24 : 1 (2023), p. 1-12. -
További szerzők:Przewosnik, Anne-Sophie Luxenburger, Hendrik Hofmann, Maike Neumann-Haefelin, Christoph Esser, Jennifer S. Siegel, Patrick M. Maier, Alexander Bojtiné Kovács Sarolta Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Csanádi Zoltán (1960-) (kardiológus) Rieder, Marina Duerschmied, Daniel Lother, Achim Bode, Christoph Szabó Gábor Tamás (1982-) (kardiológus) Czuriga Dániel (1982-) (kardiológus)
Pályázati támogatás:DRKS00026655
Egyéb
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2.

001-es BibID:BIBFORM103008
035-os BibID:(cikkazonosító)873899 (WOS)000836963900001 (Scopus)85135499583
Első szerző:Csató Gábor
Cím:Predictors of restenosis following percutaneous coronary stent implantation : the role of trimetazidine therapy / Csató Gábor, Erdei Nóra, Ványai Beatrix, Balla Tímea, Czuriga Dániel, Csanádi Zoltán, Koszegi Zsolt, Édes István, Szabó Gábor Tamás
Dátum:2022
ISSN:2297-055X
Megjegyzések:Aims: In-stent restenosis (ISR) is an unresolved problem following percutaneous coronary intervention (PCI), having a negative impact on clinical outcome. The main goal of this study was to find new independent predictors that may influence the development of ISR. Methods and results: In this retrospective analysis, 653 PCI patients were involved. All patients had coronary stent implantation and a follow-up coronary angiography. Based on the presence of ISR at follow-up, patients were divided into two groups: 221 in the ISR and 432 in the control group. When evaluating the medical therapy of patients, significantly more patients were on trimetazidine (TMZ) in the control compared to the ISR group (p = 0.039). TMZ was found to be an independent predictor of a lower degree of ISR development (p = 0.007). TMZ treatment was especially e??ective in baremetal stent (BMS)-implanted chronic coronary syndrome (CCS) patients with narrow coronary arteries. The inflammation marker neutrophil to lymphocyte ratio (NLR) was significantly elevated at baseline in the ISR group compared to controls. The reduction of post-PCINLR was associated with improved e cacy of TMZ to prevent ISR development. Drug eluting stent implantation (p<0.001) and increased stent diameter (p<0.001) were themost important independent predictors of a lower degree of ISR development, while the use of longer stents (p = 0.005) was a major independent predictor of an increased ISR risk. Conclusion: TMZ reduces the occurrence of ISR following PCI, with special e??ectiveness in BMS-implanted patients having CCS and narrow coronary arteries. TMZ treatmentmay help to lower ISR formation in countries with high BMS utilization rates.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
in-stent restenosis
trimetazidine (TMZ)
percutaneous coronary intervention (PCI)
anti-inflammatory effect
stent implantation
Megjelenés:Frontiers in Cardiovascular Medicine. - 9 (2022), p. 1-9. -
További szerzők:Erdei Nóra (1979-) (orvos) Ványai Beatrix (1993-) (általános orvos) Balla Tímea Czuriga Dániel (1982-) (kardiológus) Csanádi Zoltán (1960-) (kardiológus) Kőszegi Zsolt (1962-) (kardiológus, belgyógyász) Édes István (1952-) (kardiológus) Szabó Gábor Tamás (1982-) (kardiológus)
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3.

001-es BibID:BIBFORM091394
035-os BibID:(cikkazonosító)969
Első szerző:Szabó Gábor Tamás (kardiológus)
Cím:Predictors of Hospital Mortality in Patients with Acute Coronary Syndrome Complicated by Cardiogenic Shock / Szabó Gábor Tamás, Ágoston András, Csató Gábor, Rácz Ildikó, Bárány Tamás, Uzonyi Gábor, Szokol Miklós, Sármán Balázs, Jebelovszki Éva, Édes István Ferenc, Czuriga Dániel, Kolozsvári Rudolf, Csanádi Zoltán, Édes István, Kőszegi Zsolt
Dátum:2021
ISSN:1424-8220
Megjegyzések:As demonstrated by earlier studies, pre-hospital triage with trans-telephonic electrocardiogram (TTECG) and direct referral for catheter therapy shows great value in the management of out-of-hospital chest pain emergencies. It does not only improve in-hospital mortality in ST-segment elevation myocardial infarction, but it has also been identified as an independent predictor of higher in-hospital survival rate. Since TTECG-facilitated triage shortens both transport time and percutaneous coronary intervention (PCI)-related procedural time intervals, it was hypothesized that even high-risk patients with acute coronary syndrome (ACS) and cardiogenic shock (CS) might also benefit from TTECG-based triage. Here, we decided to examine our database for new triage- and left ventricular (LV) function-related parameters that can influence in-hospital mortality in ACS complicated by CS. ACS patients were divided into two groups, namely, (1) hospital death patients (n = 77), and (2) hospital survivors (control, n = 210). Interestingly, TTECG-based consultation and triage of CS and ACS patients were confirmed as significant independent predictors of lower hospital mortality risk (odds ratio (OR) 0.40, confidence interval (CI) 0.21?0.76, p = 0.0049). Regarding LV function and blood chemistry, a good myocardial reperfusion after PCI (high area at risk (AAR) blush score/AAR LV segment number; OR 0.85, CI 0.78?0.98, p = 0.0178) and high glomerular filtration rate (GFR) value at the time of hospital admission (OR 0.97, CI 0.96?0.99, p = 0.0042) were the most crucial independent predictors of a decreased risk of in-hospital mortality in this model. At the same time, a prolonged time interval between symptom onset and hospital admission, successful resuscitation, and higher peak creatine kinase activity were the most important independent predictors for an increased risk of in-hospital mortality. In ACS patients with CS, (1) an early TTECG-based eleconsultation and triage, as well as (2) good myocardial perfusion after PCI and a high GFR value at the time of hospital admission, appear as major independent predictors of a lower in-hospital mortality rate.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Sensors. - 21 : 3 (2021), p. 1-13. -
További szerzők:Ágoston András Csató Gábor Rácz Ildikó (1973-) (kardiológus) Bárány Tamás Uzonyi Gábor Szokol Miklós (1971-) (kardiológus) Sármán Balázs (1976-) (kardiológus) Jebelovszki Éva Édes István Ferenc (1980-) (kardiológus) Czuriga Dániel (1982-) (kardiológus) Kolozsvári Rudolf (1976-) (kardiológus) Csanádi Zoltán (1960-) (kardiológus) Édes István (1952-) (kardiológus) Kőszegi Zsolt (1962-) (kardiológus, belgyógyász)
Pályázati támogatás:GINOP-2.3.2-15-2016-00043
GINOP
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4.

001-es BibID:BIBFORM088246
Első szerző:Szabó Gábor Tamás (kardiológus)
Cím:Hypothetical dysfunction of the epithelial sodium channel may justify neurohumoral blockade in coronavirus disease 2019 / Szabó Gábor Tamás, Kiss Attila, Csanádi Zoltán, Czuriga Dániel
Dátum:2021
ISSN:2055-5822
Megjegyzések:Since the outbreak of the COVID-19 pandemic, substantial effort has been made to understand the mechanism behind increased mortality in infected patients with pre-existing cardiovascular (CV) conditions. As the angiotensin-converting enzyme 2 (ACE2) on the host cell membrane serves as a known cellular entry point for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the use of renin-angiotensin-aldosterone system (RAAS) inhibitors seemed to pose an increased risk due to the potential upregulation of ACE2. In fact, initial assumptions concerning this issue were proven wrong when data regarding the beneficial effects of these drugs in SARS-CoV-2-infected cardiac patients surfaced. Here, we raise a novel hypothesis on the role of the epithelial sodium channel (ENaC) in the cascade of RAAS-mediated CV regulation in COVID-19 cases. Our assumption is based on the potentially reduced bioavailability of the endoprotease furin, leading to insufficient ENaC activation and consequently, RAAS upregulation. This unique mechanism may, in part, be responsible for the advantages of RAAS inhibition in the treatment of COVID-19 patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
EPITHELIAL SODIUM CHANNEL
CORONAVIRUS DISEASE
ACE2
COVID-19
Megjelenés:ESC Heart Failure. - 8 : 1 (2021), p. 171-174. -
További szerzők:Kiss Attila Csanádi Zoltán (1960-) (kardiológus) Czuriga Dániel (1982-) (kardiológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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