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001-es BibID:	BIBFORM020103
Első szerző:	Erdei Nóra (orvos)
Cím:	High-fat diet-induced reduction in nitric oxide-dependent arteriolar dilation in rats: role of xanthine oxidase-derived superoxide anion / Nóra Erdei, Attila Tóth, Enikő T. Pásztor, Zoltán Papp, István Édes, Akos Koller, Zsolt Bagi
Dátum:	2006
ISSN:	0363-6135
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	American Journal Of Physiology-Heart And Circulatory Physiology. - 291 : 5 (2006), p. H2107-H2115. -
További szerzők:	Tóth Attila (1971-) (biológus) Pásztorné Tóth Enikő (1966-) (laboratóriumi analitikus) Papp Zoltán (1965-) (kardiológus, élettanász) Édes István (1952-) (kardiológus) Koller Ákos Bagi Zsolt (1974-) (orvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM064197
Első szerző:	Kovács Árpád (kardiológus)
Cím:	Renin overexpression leads to increased titin-based stiffness contributing to diastolic dysfunction in hypertensive mRen2 rats / Árpád Kovács, Gábor Á. Fülöp, Andrea Kovács, Tamás Csípő, Beáta Bódi, Dániel Priksz, Béla Juhász, Lívia Beke, Zoltán Hendrik, Gábor Méhes, Henk L. Granzier, István Édes, Miklós Fagyas, Zoltán Papp, Judit Barta, Attila Tóth
Dátum:	2016
ISSN:	0363-6135
Megjegyzések:	Hypertension (HTN) is a major risk factor for heart failure. We investigated the influence of HTN on cardiac contraction and relaxation in transgenic renin overexpressing rats (carrying mouse Ren-2 renin gene, mRen2, n = 6). Blood pressure (BP) was measured. Cardiac contractility was characterized by echocardiography, cellular force measurements, and biochemical assays were applied to reveal molecular mechanisms. Sprague-Dawley (SD) rats (n = 6) were used as controls. Transgenic rats had higher circulating renin activity and lower cardiac angiotensin-converting enzyme two levels. Systolic BP was elevated in mRen2 rats (235.11 ? 5.32 vs. 127.03 ? 7.56 mmHg in SD, P < 0.05), resulting in increased left ventricular (LV) weight/body weight ratio (4.05 ? 0.09 vs. 2.77 ? 0.08 mg/g in SD, P < 0.05). Transgenic renin expression had no effect on the systolic parameters, such as LV ejection fraction, cardiomyocyte Ca(2+)-activated force, and Ca(2+) sensitivity of force production. In contrast, diastolic dysfunction was observed in mRen2 compared with SD rats: early and late LV diastolic filling ratio (E/A) was lower (1.14 ? 0.04 vs. 1.87 ? 0.08, P < 0.05), LV isovolumetric relaxation time was longer (43.85 ? 0.89 vs. 28.55 ? 1.33 ms, P < 0.05), cardiomyocyte passive tension was higher (1.74 ? 0.06 vs. 1.28 ? 0.18 kN/m(2), P < 0.05), and lung weight/body weight ratio was increased (6.47 ? 0.24 vs. 5.78 ? 0.19 mg/g, P < 0.05), as was left atrial weight/body weight ratio (0.21 ? 0.03 vs. 0.14 ? 0.03 mg/g, P < 0.05). Hyperphosphorylation of titin at Ser-12742 within the PEVK domain and a twofold overexpression of protein kinase C-? in mRen2 rats were detected. Our data suggest a link between the activation of renin-angiotensin-aldosterone system and increased titin-based stiffness through phosphorylation of titin's PEVK element, contributing to diastolic dysfunction.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk hypertension passive stiffness renin-angiotensin-aldosterone system RAAS diastolic dysfunction titin phosphorylation
Megjelenés:	American Journal Of Physiology-Heart And Circulatory Physiology. - 310 : 11 (2016), p. H1671-H1682. -
További szerzők:	Fülöp Gábor Áron (1988-) (általános orvos) Kovács Andrea (1974-) (neurológus) Csípő Tamás (1990-) Bódi Beáta (1989-) (molekuláris biológus) Priksz Dániel (1989-) (farmakológus) Juhász Béla (1978-) (kísérletes farmakológus) Beke Lívia Hendrik Zoltán (1986-) (orvos) Méhes Gábor (1966-) (patológus) Granzier, Henk L. Édes István (1952-) (kardiológus) Fagyas Miklós (1984-) (orvos) Papp Zoltán (1965-) (kardiológus, élettanász) Barta Judit (1975-) (kardiológus) Tóth Attila (1971-) (biológus)
Pályázati támogatás:	PD116212 OTKA K109083 OTKA K116940 OTKA MEDIA FP7
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM100043
035-os BibID:	(WoS)000749267000001 (Scopus)85123922388
Első szerző:	Phan, Thieu X.
Cím:	TRPV1 in arteries enables a rapid myogenic tone / Phan Thieu X., Ton Hoai T., Gulyás Hajnalka, Pórszász Róbert, Tóth Attila, Russo Rebekah, Kay Matthew W., Sahibzada Niaz, Ahern Gerard P.
Dátum:	2022
ISSN:	0022-3751 1469-7793
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal Of Physiology-London. - 600 : 7 (2022), p. 1651-1666. -
További szerzők:	Ton, Hoai T. Gulyás Hajnalka Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus) Tóth Attila (1971-) (biológus) Russo, Rebekah Kay, Matthew W. Sahibzada, Niaz Ahern, Gerard P.
Pályázati támogatás:	OTKA-116940 OTKA GINOP-2.3.2-15-2016-00043 GINOP GINOP-2.3.2-15-2016-00050 GINOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM093229
035-os BibID:	(WoS)000575298800001 (Scopus)85092112476
Első szerző:	Phan, Thieu X.
Cím:	TRPV1 expressed throughout the arterial circulation regulates vasoconstriction and blood pressure / Thieu X. Phan, Hoai T. Ton, Hajnalka Gulyás, Róbert Pórszász, Attila Tóth, Rebekah Russo, Matthew W. Kay, Niaz Sahibzada, Gerard P. Ahern
Dátum:	2020
ISSN:	0022-3751 1469-7793
Megjegyzések:	The functional roles of the capsaicin receptor, TRPV1, outside of sensory nerves are unclear. We mapped TRPV1 in the mouse circulation, revealing extensive expression in the smooth muscle of resistance arterioles supplying skeletal muscle, heart and adipose tissue. Activation of TRPV1 in vascular myocytes constricted arteries, reduced coronary flow in isolated hearts and increased systemic blood pressure. These functional effects were retained after sensory nerve ablation, indicating specific signalling by arterial TRPV1. TRPV1 mediated the vasoconstrictive and blood pressure responses to the endogenous inflammatory lipid lysophosphatidic acid. These results show that TRPV1 in arteriolar myocytes modulates regional blood flow and systemic blood pressure, and suggest that TRPV1 may be a target of vasoactive inflammatory mediators. The capsaicin receptor, TRPV1, is a key ion channel involved in inflammatory pain signalling. Although mainly studied in sensory nerves, there are reports of TRPV1 expression in isolated segments of the vasculature, but whether the channel localizes to vascular endothelium or smooth muscle is controversial and the distribution and functional roles of TRPV1 in arteries remain unknown. We mapped functional TRPV1 expression throughout the mouse arterial circulation. Analysis of reporter mouse lines TRPV1(PLAP-nlacZ)and TRPV1-Cre:tdTomato combined with Ca(2+)imaging revealed specific localization of TRPV1 to smooth muscle of terminal arterioles in the heart, adipose tissue and skeletal muscle. Capsaicin evoked inward currents (current density similar to 10% of sensory neurons) and raised intracellular Ca(2+)levels in arterial smooth muscle cells, constricted arteriolesex vivoandin vivoand increased systemic blood pressure in mice and rats. Further, capsaicin markedly and dose-dependently reduced coronary flow. Pharmacological and/or genetic disruption of TRPV1 abolished all these effects of capsaicin as well as vasoconstriction triggered by lysophosphatidic acid, a bioactive lipid generated by platelets and atherogenic plaques. Notably, ablation of sensory nerves did not affect the responses to capsaicin revealing a vascular smooth muscle-restricted signalling mechanism. Moreover, unlike in sensory nerves, TRPV1 function in arteries was resistant to activity-induced desensitization. Thus, TRPV1 activation in vascular myocytes enables a persistent depolarizing current, leading to constriction of coronary, skeletal muscle and adipose arterioles and a sustained increase in systemic blood pressure.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk TRPV1 blood pressure capsaicin lysophosphatidic acid vascular smooth muscle
Megjelenés:	Journal of Physiology. - 598 : 24 (2020), p. 5639-5659. -
További szerzők:	Ton, Hoai T. Gulyás Hajnalka Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus) Tóth Attila (1971-) (biológus) Russo, Rebekah Kay, Matthew W. Niaz, Sahibzada Ahern, Gerard P.
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