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001-es BibID:BIBFORM065084
Első szerző:Úri Katalin
Cím:Circulating ACE2 activity correlates with cardiovascular disease development / Katalin Úri, Miklós Fagyas, Attila Kertész, Attila Borbély, Csaba Jenei, Orsolya Bene, Zoltán Csanádi, Walter J. Paulus, István Édes, Zoltán Papp, Attila Tóth, Erzsébet Lizanecz
Dátum:2016
Megjegyzések:Abstract It was shown recently that Angiotensin Converting Enzyme activity is limited by endogenous inhibition in vivo, highlighting the importance of Angiotensin II elimination (ACE2). Potential contribution of the ACE2 to cardiovascular disease progression was addressed. Serum ACE2 activities were measured in different clinical states (healthy, n=45; hypertensive, n=239; heart failure (HF) with reduced ejection fraction (HFrEF), n=141 and HF with preserved ejection fraction (HFpEF), n=47). ACE2 activity was significantly higher in hypertensive patients (24.8?0.8U/ml) than that in healthy volunteers (16.2?0.8U/ml, P=0.01). ACE2 activity further increased in HFrEF patients (43.9?2.1U/ml, P=0.001) but not in HFpEF patients (24.6?1.9U/ml) when compared to hypertensive patients. Serum ACE2 activity negatively correlated with left ventricular systolic function in HFrEF, but not in hypertensive, HFpEF or healthy populations. Serum ACE2 activity had a fair diagnostic value to differentiate HFpEF from HFrEF patients in this study.Serum ACE2 activity correlates with cardiovascular disease development: it increases when hypertension developes and further increases when the cardiovascular disease further progresses to systolic dysfunction, suggesting that ACE2 metabolism plays a role in these processes. In contrast, serum ACE2 activity does not change when hypertension progresses to HFpEF, suggesting a different pathomechanism for HFpEF and proposing a biomarker based identification of these HF forms.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Angiotensin converting enzyme 2
diastolic heart failure
systolic heart failure
hypertension
renin-angiotensin-aldosterone system
biomarker
Megjelenés:Journal of the Renin-Angiotensin-Aldosterone System 17 : 4 (2016), p. 1-11. -
További szerzők:Fagyas Miklós (1984-) (orvos) Kertész Attila Béla (1973-) (kardiológus) Borbély Attila (1978-) (kardiológus) Jenei Csaba (1976-) (kardiológus) Bene Orsolya (1980-) (kardiológus) Csanádi Zoltán (1960-) (kardiológus) Paulus, Walter J. Édes István (1952-) (kardiológus) Papp Zoltán (1965-) (kardiológus, élettanász) Tóth Attila (1971-) (biológus) Lizanecz Erzsébet (1978-) (orvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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