CCL

Összesen 13 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM020696
Első szerző:Choi, Hyun-Kyung
Cím:Non-vanillyl resiniferatoxin analogues as potent and metabolically stable transient receptor potential vanilloid 1 agonists / Choi Hyun-Kyung, Choi Sun, Lee Yoonji, Kang Dong Wook, Ryu HyungChul, Maeng Han-Joo, Chung Suk-Jae, Pavlyukovets Vladimir A., Pearce Larry V., Toth Attila, Tran Richard, Wang Yun, Morgan Matthew A., Blumberg Peter M., Lee Jeewoo
Dátum:2009
ISSN:0968-0896
Megjegyzések:A series of non-vanillyl resiniferatoxin analogues, having 4-methylsulfonylaminophenyl and fluorophenyl moieties as vanillyl surrogates, have been investigated as ligands for rat TRPV1 heterologously expressed in Chinese hamster ovary cells. Although lacking the metabolically problematic 4-hydroxy substituent on the A-region phenyl ring, the compounds retained substantial agonist potency. Indeed, the 3-methoxy-4-methylsulfonylaminophenyl analog (1) was modestly (2.5-fold) more potent than RTX, with an EC(50)=0.106 nM. Further, it resembled RTX in its kinetics and pattern of stimulation of the levels of intracellular calcium in individual cells, as revealed by imaging. Compound 1 displayed modestly enhanced in vitro stability in rat liver microsomes and in plasma, suggesting that it might be a pharmacokinetically more favorable surrogate of resiniferatoxin. Molecular modeling analyses with selected analogues provide evidence that the conformational differences could affect their binding affinities, especially for the ester versus amide at the B-region.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Bioorganic & Medicinal Chemistry. - 17 : 2 (2009), p. 690-698. -
További szerzők:Choi, Sun Lee, Yoonji Kang, Dong Wook Ryu, HyungChul Maeng, Han-Joo Chung, Suk-Jae Pavlyukovets, Vladimir A. Pearce, Larry V. Tóth Attila (1971-) (biológus) Tran, Richard Wang, Yun Morgan, Matthew A. Blumberg, Peter M. Lee, Jeewoo
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM003725
Első szerző:Chung, Jae-Uk
Cím:Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists / Chung, J. U., Kim, S. Y., Lim, J. O., Choi, H. K., Kang, S. U., Yoon, H. S., Ryu, H., Kang, D. W., Lee, J., Kang, B., Choi, S., Toth, A., Pearce, L. V., Pavlyukovets, V. A., Lundberg, D. J., Blumberg, P. M.
Dátum:2007
Megjegyzések:A series of alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues have been investigated as TRPV1 receptor antagonists. alpha-Methyl substituted analogues showed potent and stereospecific antagonism to the action of capsaicin on rat TRPV1 heterologously expressed in Chinese hamster ovary cells. In particular, compounds 14 and 18, which possess the R-configuration, exhibited excellent potencies (respectively, K(i)=41 and 39.2 nM and K(i(ant))=4.5 and 37 nM)
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Animals
antagonists &amp
Calcium
Capsaicin
Cells,Cultured
chemical synthesis
chemistry
Cho Cells
Cricetinae
Cricetulus
inhibitors
metabolism
Models,Molecular
Molecular Structure
pharmacology
Rats
Stereoisomerism
Structure-Activity Relationship
Thiourea
TRPV Cation Channels
Megjelenés:Bioorganic and Medical Chemistry. - 15 : 18 (2007), p. 6043-6053. -
További szerzők:Kim, Su Yeon Lim, Ju-Ok Choi, Hyun-Kyung Kang, Sang-Uk Yoon, Hae-Seok Ryu, HyungChul Kang, Dong Wook Lee, Jeewoo Kang, Bomi Choi, Sun Tóth Attila (1971-) (biológus) Pearce, Larry V. Pavlyukovets, Vladimir A. Lundberg, Daniel J. Blumberg, Peter M.
Internet cím:elektronikus változat
DOI
Borító:

3.

001-es BibID:BIBFORM020697
Első szerző:Lázár József
Cím:Kinetics of Penetration Influence the Apparent Potency of Vanilloids on TRPV1 / Jozsef Lazar, Derek C. Braun, Attila Tóth, Yun Wang, Larry V. Pearce, Vladimir A. Pavlyukovets, Peter M. Blumberg, Susan H. Garfield, Stephen Wincovitch, Hyun-Kyung Choi, and Jeewoo Lee
Dátum:2006
ISSN:0026-895X
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Molecular Pharmacology. - 69 : 4 (2006), p. 1166-1173. -
További szerzők:Braun, Derek C. Tóth Attila (1971-) (biológus) Wang, Yun Pearce, Larry V. Pavlyukovets, Vladimir A. Blumberg, Peter M. Garfield, Susan H. Wincovitch, Stephen Choi, Hyun-Kyung Lee, Jeewoo
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM058125
Első szerző:Lee, Jeewoo
Cím:Analysis of structure-activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism / Jeewoo Lee, Su Yeon Kim, Jiyoun Lee, Myungsim Kang, Min-Jung Kil, Hyun-Kyung Choi, Mi-Kyung Jin, Yun Wang, Attila Toth, Larry V. Pearce, Daniel J. Lundberg, Richard Tran, Peter M. Blumberg
Dátum:2004
ISSN:0968-0896
Megjegyzések:In a continuing effort to elucidate the structure-activity relationships of the lead antagonist N-[2-(3,4-dimethylbenzyl)-3-pivaloyloxypropyl]-N'-[4-(methylsulfonylamino)benzyl]thiourea (1), the distances between the proposed four pharmacophores in 1 have been varied by insertion or deletion of one carbon to optimize their fit to the receptor. In addition, the acyloxy group of the C region was replaced with amide and N-hydroxy amide to identify the pharmacophoric importance of the ester group in the C2 region. The results indicated that the pharmacophoric arrangement of 1 was optimal for receptor binding affinity and antagonism, and the ester of the C2 region was significant for receptor binding. Among the derivatives, compound 19 showed distinct behavior with a 2-fold improvement in antagonism but a 13-fold reduction in binding affinity compared to 1. The partial separation of pharmacophoric requirements of these two assays has been noted before and compound 19 is thus selective for the calcium entry-linked receptor population. The conformational analysis of 1 generated three distinct conformers having different types of hydrophobic interactions, which will be utilized for exploring the active conformation of the VR1 ligand.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Bioorganic & Medicinal Chemistry. - 12 : 13 (2004), p. 3411-3420. -
További szerzők:Kim, Su Yeon Lee, Jiyoun Kang, Myungshim Kil, Min-Jung Choi, Hyun-Kyung Jin, Mi-Kyung Wang, Yun Tóth Attila (1971-) (biológus) Pearce, Larry V. Lundberg, Daniel J. Tran, Richard Blumberg, Peter M.
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM058129
Első szerző:Lee, Jeewoo
Cím:Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists : discovery of an N-hydroxythiourea analogue with potent analgesic activity / Jeewoo Lee, Sang-Uk Kang, Hyun-Kyung Choi, Jiyoun Lee, Ju-Ok Lim, Min-Jung Kil, Mi-Kyung Jin, Kang-Pil Kim, Jong-Hyuk Sung, Suk-Jae Chung, Hee-Jin Ha, Young-Ho Kim, Larry V. Pearce, Richard Tran, Daniel J. Lundberg, Yun Wang, Attila Toth, Peter M. Blumberg
Dátum:2004
ISSN:0960-894X
Megjegyzések:The structural modifications on the B-region of the potent and high affinity vanilloid receptor (VR1) lead ligand N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea were investigated by the replacement of the thiourea with diverse isosteric functional groups. Structure-activity analysis indicated that the A-region in this series was the primary factor in determining the agonistic/antagonistic activities regardless of the B-region. The N(C)-hydroxy thiourea analogues (12, 13) showed excellent analgesic activities in the acetic acid writhing assay compared to the parent thiourea analogues.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Bioorganic & Medicinal Chemistry Letters. - 14 : 9 (2004), p. 2291-2297. -
További szerzők:Kang, Sang-Uk Choi, Hyun-Kyung Lee, Jiyoun Lim, Ju-Ok Kil, Min-Jung Jin, Mi-Kyung Kim, Kang-Pil Sung, Jong-Hyuk Chung, Suk-Jae Ha, Hee-Jin Kim, Young-Ho Pearce, Larry V. Tran, Richard Lundberg, Daniel J. Wang, Yun Tóth Attila (1971-) (biológus) Blumberg, Peter M.
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

6.

001-es BibID:BIBFORM058133
Első szerző:Lee, Jeewoo
Cím:N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues : novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor / Jeewoo Lee, Jiyoun Lee, Myungshim Kang, Myoungyoup Shin, Ji-Min Kim, Sang-Uk Kang, Ju-Ok Lim, Hyun-Kyung Choi, Young-Ger Suh, Hyeung-Geun Park, Uhtaek Oh, Hee-Doo Kim, Young-Ho Park, Hee-Jin Ha, Young-Ho Kim, Attila Toth, Yun Wang, Richard Tran, Larry V. Pearce, Daniel J. Lundberg, Peter M. Blumberg
Dátum:2003
ISSN:0022-2623 1520-4804
Megjegyzések:Isosteric replacement of the phenolic hydroxyl group in potent vanilloid receptor (VR1) agonists with the alkylsulfonamido group provides a series of compounds which are effective antagonists to the action of the capsaicin on rat VR1 heterologously expressed in Chinese hamster ovary (CHO) cells. In particular, compound 61, N-[2-(3,4-dimethylbenzyl)-3-pivaloyloxypropyl]-N'-[3-fluoro-4-(methylsulfonylamino)benzyl]thiourea was a full antagonist against capsaicin, displayed a K(i) value of 7.8 nM (compared to 520 nM for capsazepine and 4 nM for 5-iodoRTX), and showed excellent analgesic activity in mice. Structure-activity analysis of the influence of modifications in the A- and C-regions of 4-methylsulfonamide ligands on VR1 agonism/antagonism indicated that 3-fluoro substitution in the A-region and a 4-tert-butylbenzyl moiety in the C-region favored antagonism, whereas a 3-methoxy group in the A-region and 3-acyloxy-2-benzylpropyl moieties in the C-region favored agonism.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Medicinal Chemistry. - 46 : 14 (2003), p. 3116-3126. -
További szerzők:Lee, Jiyoun Kang, Myungshim Shin, Myoungyoup Kim, Ji-Min Kang, Sang-Uk Lim, Ju-Ok Choi, Hyun-Kyung Suh, Young-Ger Park, Hyeung-Geun Oh, Uhtaek Kim, Hee-Doo Park, Young Ho Ha, Hee-Jin Kim, Young-Ho Tóth Attila (1971-) (biológus) Wang, Yun Tran, Richard Pearce, Larry V. Lundberg, Daniel J. Blumberg, Peter M.
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

7.

001-es BibID:BIBFORM058122
Első szerző:Lee, Jeewoo
Cím:Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists / Jeewoo Lee, Mi-Kyoung Jin, Sang-Uk Kang, Su Yeon Kim, Jiyoun Lee, Myoungyoup Shin, Jaemin Hwang, Sookhyun Cho, Yeon-Sil Choi, Hyun-Kyung Choi, Sung-Eun Kim, Young-Ger Suh, Yong-Sil Lee, Young-Ho Kim, Hee-Jin Ha, Attila Toth, Larry V. Pearce, Richard Tran, Tamas Szabo, Jacqueline D. Welter, Daniel J. Lundberg, Yun Wang, Jozsef Lazar, Vladimir A. Pavlyukovets, Matthew A. Morgan, Peter M. Blumberg
Dátum:2005
ISSN:0960-894X
Megjegyzések:The structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues have been investigated as TRPV1 receptor antagonists. A docking model of potent antagonist 2 with the sensor region of TRPV1 is proposed.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Bioorganic & Medicinal Chemistry Letters. - 15 : 18 (2005), p. 4143-4150. -
További szerzők:Jin, Mi-Kyoung Kang, Sang-Uk Kim, Su Yeon Lee, Jiyoun Shin, Myoungyoup Hwang, Jaemin Cho, Sookhyun Choi, Yeon-Sil Choi, Hyun-Kyung Kim, Sung-Eun Suh, Young-Ger Lee, Yong-Sil Kim, Young-Ho Ha, Hee-Jin Tóth Attila (1971-) (biológus) Pearce, Larry V. Tran, Richard Szabó Tamás Welter, Jacqueline D. Lundberg, Daniel J. Wang, Yun Lázár József Pavlyukovets, Vladimir A. Morgan, Matthew A. Blumberg, Peter M.
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

8.

001-es BibID:BIBFORM016029
Első szerző:Lee, Jeewoo
Cím:Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists / Jeewoo Lee, Sang-Uk Kang, Min-Jung Kil, Myoungyoup Shin, Ju-Ok Lim, Hyun-Kyung Choi, Mi-Kyoung Jin, Su Yeon Kim, Sung-Eun Kim, Yong-Sil Lee, Kyung-Hoon Min, Young-Ho Kim, Hee-Jin Ha, Richard Tran, Jacqueline D. Welter, Yun Wang, Tamas Szabo, Larry V. Pearce, Daniel J. Lundberg, Attila Toth, Vladimir A. Pavlyukovets, Matthew A. Morgan, Peter M. Blumberg
Dátum:2005
ISSN:0960-894X
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Bioorganic & Medicinal Chemistry Letters. - 15 : 18 (2005), p. 4136-4142. -
További szerzők:Kang, Sang-Uk Kil, Min-Jung Shin, Myoungyoup Lim, Ju-Ok Choi, Hyun-Kyung Jin, Mi-Kyoung Kim, Su Yeon Kim, Sung-Eun Lee, Yong-Sil Min, Kyung-Hoon Kim, Young-Ho Ha, Hee-Jin Tran, Richard Welter, Jacqueline D. Wang, Yun Szabó Tamás (1968-) (gyermekgyógyász) Pearce, Larry V. Lundberg, Daniel J. Tóth Attila (1971-) (biológus) Pavlyukovets, Vladimir A. Morgan, Matthew A. Blumberg, Peter M.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

9.

001-es BibID:BIBFORM016034
Első szerző:Lee, Jeewoo
Cím:N-[4-(Methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists : analysis of structure-activity relationships for the 'C-Region' / Jeewoo Lee, Sang-Uk Kang, Ju-Ok Lim, Hyun-Kyung Choi, Mi-Kyung Jin, Attila Toth, Larry V. Pearce, Richard Tran, Yun Wang, Tamas Szabo, Peter M. Blumberg
Dátum:2004
ISSN:0968-0896
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Bioorganic & Medicinal Chemistry. - 12 : 2 (2004), p. 371-385. -
További szerzők:Kang, Sang-Uk Lim, Ju-Ok Choi, Hyun-Kyung Jin, Mi-Kyung Tóth Attila (1971-) (biológus) Pearce, Larry V. Tran, Richard Wang, Yun Szabó Tamás (1968-) (gyermekgyógyász) Blumberg, Peter M.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

10.

001-es BibID:BIBFORM016033
Első szerző:Lee, Jeewoo
Cím:Structure-activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding / Jeewoo Lee, Su Yeon Kim, Soyoung Park, Ju-Ok Lim, Ji-Min Kim, Myungshim Kang, Jiyoun Lee, Sang-Uk Kang, Hyun-Kyung Choi, Mi-Kyung Jin, Jacqueline D. Welter, Tamas Szabo, Richard Tran, Larry V. Pearce, Attila Toth, Peter M. Blumberg
Dátum:2004
ISSN:0968-0896
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Bioorganic & Medicinal Chemistry. - 12 : 5 (2004), p. 1055-1069. -
További szerzők:Kim, Su Yeon Park, Soyoung Lim, Ju-Ok Kim, Ji-Min Kang, Myungshim Lee, Jiyoun Kang, Sang-Uk Choi, Hyun-Kyung Jin, Mi-Kyung Welter, Jacqueline D. Szabó Tamás (1968-) (gyermekgyógyász) Tran, Richard Pearce, Larry V. Tóth Attila (1971-) (biológus) Blumberg, Peter M.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

11.

001-es BibID:BIBFORM005638
Első szerző:Pearce, Larry V.
Cím:Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors / Pearce, L. V., Toth, A., Ryu, H., Kang, D. W., Choi, H. K., Jin, M. K., Lee, J., Blumberg, P. M.
Dátum:2008
ISSN:0028-1298 (Print)
Megjegyzések:The transient receptor potential V1 channel (vanilloid receptor, TRPV1) represents a promising therapeutic target for inflammatory pain and other conditions involving C-fiber sensory afferent neurons. Sensitivity of TRPV1 is known to be subject to modulation by numerous signaling pathways, in particular by phosphorylation, and we wished to determine whether TRPV1 structure activity relations could be differentially affected. We demonstrate here that the structure activity relations of TRPV1, as determined by (45)Ca(2) uptake, were substantially altered by treatment of the cells with cyclosporin A, an inhibitor of protein phosphatase 2B. Whereas the potency of resiniferatoxin for stimulation of (45)Ca(2) was not altered by cyclosporin A treatment, the potencies of some other agonists were increased up to 8-fold. Among the antagonists examined, potencies were reduced to a lesser extent, ranging from 1- to 2.5-fold. Finally, the efficacy of partial agonists was increased. In contrast to cyclosporin A, okadaic acid, an inhibitor of protein phosphatases 1 and 2A, had little effect on agonist potencies, and calyculin A, an inhibitor of protein phosphatases 1 and 2A but with somewhat different selectivity from that of okadaic acid, caused changes in structure activity relations distinct from those induced by cyclosporin A. Because phosphatase activity differentially modulates the structure activity relations of TRPV1 agonists and antagonists, our findings predict that it may be possible to design agonists and antagonists selective for TRPV1 in a specific regulatory environment. A further implication is that it may be desirable to tailor screening approaches for drug discovery to reflect the desired regulatory state of the targeted TRPV1.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Animals
CHO Cells
Calcium/metabolism
Capsaicin/analogs & derivatives/pharmacology
Cricetinae
Cricetulus
Cyclosporine/ pharmacology
Enzyme Inhibitors/ pharmacology
Phosphoprotein Phosphatases/ antagonists & inhibitors
Rats
Structure-Activity Relationship
TRPV Cation Channels/ agonists/ antagonists & inhibitors
Megjelenés:Naunyn-Schmiedeberg's Archives of Pharmacology. - 377 : 2 (2008), p. 149-157. -
További szerzők:Tóth Attila (1971-) (biológus) Ryu, HyungChul Kang, Dong Wook Choi, Hyun-Kyung Jin, Mi-Kyoung Lee, Jeewoo Blumberg, Peter M.
Internet cím:elektronikus változat
Borító:

12.

001-es BibID:BIBFORM005639
Első szerző:Ryu, HyungChul
Cím:Stereospecific high-affinity TRPV1 antagonists : chiral N-(2-benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues / Ryu, H., Jin, M. K., Kim, S. Y., Choi, H. K., Kang, S. U., Kang, D. W., Lee, J., Pearce, L. V., Pavlyukovets, V. A., Morgan, M. A., Tran, R., Toth, A., Lundberg, D. J., Blumberg, P. M.
Dátum:2008
ISSN:0022-2623 (Print)
Megjegyzések:Previously, we reported the thiourea antagonists 2a and 2b as potent and high affinity TRPV1 antagonists. For further optimization of the lead compounds, a series of their amide and alpha-substituted amide surrogates were investigated and novel chiral N-(2-benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues were characterized as potent and stereospecific rTRPV1 antagonists. In particular, compounds 72 and 73 displayed high binding affinities, with K i values of 4.12 and 1.83 nM and potent antagonism with K i values of 0.58 and 5.2 nM, respectively, in rTRPV1/CHO cells. These values are comparable or more potent than those of 5-iodoRTX under the same assay conditions. A distinctive binding model that includes two hydrophobic pockets is proposed for this series of compounds based on docking studies of 57 and 72 with a homology model of the TM3/4 region of TRPV1.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Animals
Benzeneacetamides
Binding Sites
Binding, Competitive
CHO Cells
Calcium/metabolism
Cricetinae
Cricetulus
Hydrophobicity
Mesylates
Models, Molecular
Radioligand Assay
Rats
Stereoisomerism
Structure-Activity Relationship
TRPV Cation Channels
Megjelenés:Journal of Medicinal Chemistry. - 51 : 1 (2008), p. 57-67. -
További szerzők:Jin, Mi-Kyoung Kim, Su Yeon Choi, Hyun-Kyung Kang, Sang-Uk Kang, Dong Wook Lee, Jeewoo Pearce, Larry V. Pavlyukovets, Vladimir A. Morgan, Matthew A. Tran, Richard Tóth Attila (1971-) (biológus) Lundberg, Daniel J. Blumberg, Peter M.
Internet cím:elektronikus változat
Borító:
Rekordok letöltése1 2