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001-es BibID:BIBFORM085606
Első szerző:Cséplő Péter
Cím:Hemolyzed Blood Elicits a Calcium Antagonist and High CO2 Reversible Constriction via Elevation of [Ca2+] in Isolated Cerebral Arteries / Cseplo Peter, Vamos Zoltan, Torok Orsolya, Ivic Ivan, Toth Attila, Buki Andras, Koller Akos
Dátum:2017
ISSN:0897-7151
Megjegyzések:During acute subarachnoid hemorrhage, blood is hemolyzed, which is followed by a significant cerebrovascular spasm resulting in a serious clinical condition. Interestingly, however, the direct vasomotor effect of perivascular hemolyzed blood (HB) has not yet been characterized, preventing the assessment of contribution of vasoconstrictor mechanisms deriving from brain tissue and/or blood and development of possible treatments. We hypothesized that perivascular HB reduces the diameter of the cerebral arteries (i.e., basilar artery [BA]; middle cerebral artery [MCA]) by elevating vascular tissue [Ca2+]i level. Vasomotor responses were measured by videomicroscopy and intracellular Ca2+ by the Fura2-AM ratiometric method. Adding HB to the vessel chamber reduced the diameter significantly (BA: from 264???7 to 164???11??m; MCA: from 185???15 to 155???14??m), which was reversed to control level by wash-out of HB. Potassium chloride (KCl), HB, serum, hemolyzed red blood cell (RBC), plasma, and platelet suspension (PLTs) elicited significant constrictions of isolated basilar arteries. There was a significant increase in K+ concentration in hemolyzed HB (7.02???0.22?mmol/L) compared to Krebs' solution (6.20???0.01?mmol/L). Before HB, acetylcholine (ACh), sodium-nitroprussid (SNP), nifedipin, and CO2 elicited substantial dilations in cerebral arteries. In contrast, in the presence of HB dilations to ACh, SNP decreased, but not to nifedipine and CO2. After washout of HB, nitric oxide?mediated dilations remained significantly reduced compared to control. HB significantly increased the ratiometric Ca signal, which returned to control level after washout. In conclusion, perivascular hemolyzed blood elicits significant?nifedipine and high CO2 reversible?constrictions of isolated BAs and MCAs, primarily by increasing intracellular Ca2+, findings that can contribute to the refinement of local treatment of subarachnoid hemorrhage.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
subarachnoid hemorrhage
in vitro studies
vascular injury
traumatic brain injury
cbf autoregulation
Megjelenés:Journal Of Neurotrauma. - 34 : 2 (2017), p. 529-534. -
További szerzők:Vámos Zoltán Török Orsolya Ivic, Ivan Tóth Attila (1971-) (biológus) Buki András Koller Ákos
Pályázati támogatás:K 108444
OTKA
Internet cím:Szerző által megadott URL
DOI
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2.

001-es BibID:BIBFORM069693
035-os BibID:(cikkazonosító)e0164010 (WOS)000385698100016 (Scopus)84991491986
Első szerző:Cséplő Péter
Cím:The Beta-1-Receptor Blocker Nebivolol Elicits Dilation of Cerebral Arteries by Reducing Smooth Muscle [Ca2+]i / Peter Cseplo, Zoltan Vamos, Ivan Ivic, Orsolya Torok, Attila Toth, Akos Koller
Dátum:2016
ISSN:1932-6203
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:PloS One. - 11 (2016), p. 1-22. -
További szerzők:Vámos Zoltán Ivic, Ivan Török Orsolya Tóth Attila (1971-) (biológus) Koller Ákos
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
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