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001-es BibID:BIBFORM100041
035-os BibID:(WOS)000739793800001 (Scopus)85122483976
Első szerző:Nyúl-Tóth Ádám
Cím:Cerebral venous congestion exacerbates cerebral microhemorrhages in mice / Nyul-Toth Adam, Fulop Gabor A., Tarantini Stefano, Kiss Tamas, Ahire Chetan, Faakye Janet A., Ungvari Anna, Toth Peter, Toth Attila, Csiszar Anna, Ungvari Zoltan
Dátum:2022
ISSN:2509-2715 2509-2723
Megjegyzések:Cerebral microhemorrhages (CMHs; microbleeds), which are small focal intracerebral hemorrhages, importantly contribute to the pathogenesis of cognitive decline and dementia in older adults. Although recently it has been increasingly recognized that the venous side of the cerebral circulation likely plays a fundamental role in the pathogenesis of a wide spectrum of cerebrovascular and brain disorders, its role in the pathogenesis of CMHs has never been studied. The present study was designed to experimentally test the hypothesis that venous congestion can exacerbate the genesis of CMHs. Increased cerebral venous pressure was induced by internal and external jugular vein ligation (JVL) in C57BL/6 mice in which systemic hypertension was induced by treatment with angiotensin II plus L-NAME. Histological analysis (diaminobenzidine staining) showed that mice with JVL developed multiple CMHs. CMHs in mice with JVL were often localized adjacent to veins and venules and their morphology was consistent with venous origin of the bleeds. In brains of mice with JVL, a higher total count of CMHs was observed compared to control mice. CMHs were distributed widely in the brain of mice with JVL, including the cortical gray matter, brain stem, the basal ganglia, subcortical white matter, cerebellum, and the hippocampi. In mice with JVL, there were more CMHs predominantly in cerebral cortex, brain stem, and cerebellum than in control mice. CMH burden, defined as total CMH volume, also significantly increased in mice with JVL. Thus, cerebral venous congestion can exacerbate CMHs. These observations have relevance to the pathogenesis of cognitive impairment associated with right heart failure as well as elevated cerebral venous pressure due to jugular venous reflux in older adults.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Microbleed
Vascular contributions to cognitive impairment and dementia (VCID)
VCI
Vein
Venous congestion
Heart failure
Cerebral circulation
ICH
Vascular cognitive impairment
Intracerebral hemorrhage
Megjelenés:GeroScience. - 44 : 2 (2022), p. 805-816. -
További szerzők:Fülöp Gábor Áron (1988-) (általános orvos) Tarantini, Stefano Kiss Tamás Ahire, Chetan Faakye, Janet A. Ungvári Anna Tóth Péter Tóth Attila (1971-) (biológus) Csiszár Anna Ungvári Zoltán
Pályázati támogatás:TKP2020-IKA-04
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