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001-es BibID:BIBFORM094507
035-os BibID:(WoS)000531328600013 (Scopus)85081602433
Első szerző:Herishanu, Yair
Cím:Frontline treatment with the combination obinutuzumab ± chlorambucil for chronic lymphocytic leukemia outside clinical trials : results of a multinational, multicenter study by ERIC and the Israeli CLL study group / Yair Herishanu, Adir Shaulov, Riva Fineman, Sandra Bašić-Kinda, Ariel Aviv, Ewa Wasik-Szczepanek, Ozren Jaksic, Mihnea Zdrenghea, Uri Greenbaum, Inga Mandac, Martin Simkovic, Marta Morawska, Ohad Benjamini, Martin Spacek, Anatoly Nemets, Osnat Bairey, Livio Trentin, Rosa Ruchlemer, Luca Laurenti, Oana Stanca Ciocan, Michael Doubek, Lev Shvidel, Nagib Dali, Fátima Mirás, Anne De Meûter, Maria Dimou, Francesca R. Mauro, Marta Coscia, Horia Bumbea, Róbert Szász, Tamar Tadmor, Odit Gutwein, Massimo Gentile, Lydia Scarfò, Alessandra Tedeschi, Paolo Sportoletti, Eva Gimeno Vázquez, Juan Marquet, Sarit Assouline, Maria Papaioannou, Andrei Braester, Luciano Levato, Michael Gregor, Gian M. Rigolin, Javier Loscertales, Angeles Medina Perez, Marten R. Nijziel, Viola M. Popov, Rosa Collado, Irma Slavutsky, Gilad Itchaki, Shimrit Ringelstein, Neta Goldschmidt, Chava Perry, Shai Levi, Aaron Polliack, Paolo Ghia
Dátum:2020
ISSN:0361-8609 1096-8652
Megjegyzések:In recent years, considerable progress has been made in frontline therapy for elderly/physically unfit patients with CLL. The combination of obinutuzumab and chlorambucil (O-Clb) has been shown to prolong progression free survival (PFS, median PFS-31.5?months) and overall survival (OS) compared to chlorambucil alone. More recently, obinutuzumab given in combination with either ibrutinib or venetoclax improved PFS but not OS when compared to O-Clb. In this retrospective multinational, multicenter co-operative study, we evaluated the efficacy and safety of frontline treatment with O???Clb in unfit patients with CLL, in a "real-world" setting. Patients with documented del (17p13.1)/TP53 mutation were excluded. A total of 437 patients (median age, 75.9?years; median CIRS score, 8; median creatinine clearance, 61.1 mL/min) were included. The clinical overall response rate was 80.3% (clinical complete and partial responses in 38.7% and 41.6% of patients, respectively). Median observation time was 14.1 months and estimated median PFS was 27.6 months (95% CI, 24.2-31.0). In a multivariate analysis, high-risk disease [del (11q22.3) and/or IGHV-unmutated], lymph nodes of diameter?>?5 cm, obinutuzumab monotherapy and reduced cumulative dose of obinutuzumab, were all independently associated with shorter PFS. The median OS has not yet been reached and estimated 2-year OS is 88%. In conclusion, in a "real-world" setting, frontline treatment with O-Clb achieves PFS comparable to that reported in clinical trials. Inferior outcomes were noted in patients with del (11q22.3) and/or unmutated IGHV and those treated with obinutuzumab-monotherapy. Thus, O-Clb can be still considered as legitimate frontline therapy for unfit CLL patients with low-risk disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
krónikus lymphoid leukaemia
obinutuzumab
kemoimmunoterápia
Megjelenés:American Journal of Hematology. - 95 : 6 (2020), p. 604-611. -
További szerzők:Shaulov, Adir Fineman, Riva Bašić-Kinda, Sandra Aviv, Ariel Wasik-Szczepanek, Ewa Jaksic, Ozren Zdrenghea, Mihnea Greenbaum, Uri Mandac, Inga Simkovic, Martin Morawska, Marta Benjamini, Ohad Spacek, Martin Nemets, Anatoly Bairey, Osnat Trentin, Livio Ruchlemer, Rosa Laurenti, Luca Stanca Ciocan, Oana Doubek, Michael Shvidel, Lev Dali, Nagib Mirás, Fátima Meûter, Anne De Dimou, Maria Mauro, Francesca R. Coscia, Marta Bumbea, Horia Szász Róbert (1972-) (belgyógyász, haematológus) Tadmor, Tamar Gutwein, Odit Gentile, Massimo Scarfò, Lydia Tedeschi, Alessandra Sportoletti, Paolo Gimeno Vázquez, Eva Marquet, Juan Assouline, Sarit Papaioannou, Maria Braester, Andrei Levato, Luciano Gregor, Michael Rigolin, Gian M. Loscertales, Javier Medina Perez, Angeles Nijziel, Marten R. Popov, Viola M. Collado, Rosa Slavutsky, Irma Itchaki, Gilad Ringelstein, Shimrit Goldschmidt, Neta Perry, Chava Levi, Shai Polliack, Aaron Ghia, Paolo
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