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001-es BibID:	BIBFORM094533
Első szerző:	Prodan, Calin I.
Cím:	Coated-platelets retain amyloid precursor protein on their surface / Calin I. Prodan, Robert Szasz, Andrea S. Vincent, Elliott D. Ross, George L. Dale
Dátum:	2006
ISSN:	0953-7104
Megjegyzések:	Coated-Platelets are a subset of platelets produced by dual-agonist activation with collagen plus thrombin and are characterized by strong retention of several procoagulant, alpha-granule proteins on the cell surface. In this report we demonstrate that coated-platelets also retain full-length amyloid precursor protein (APP) on their surface in contrast to the cleavage of APP in platelets activated with a single agonist. In addition, western blot analysis indicated that APP is derivatized during coated-platelet synthesis. We subsequently measured coated-platelet production in patients with Alzheimer's disease (AD). Twenty-two AD patients showed a wide distribution of coated-platelet values; however the least impaired AD patients produced coated-platelets at a level significantly above that of aged controls (41.0 +/- 9.9 vs. 28.7 +/- 11.4%; mean +/- 1SD; p = 0.017). These findings suggest that coated-platelets may be a model of aberrant APP processing in early AD patients.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk COAT platelets amyloid
Megjelenés:	Platelets. - 17 : 1 (2006), p. 56-60. -
További szerzők:	Szász Róbert (1972-) (belgyógyász, haematológus) Vincent, Andrea S. Ross, Elliott D. Dale, George L.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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