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001-es BibID:BIBFORM082080
035-os BibID:(cikkazonosító)1958 (WoS)000502294400201 (Scopus)85111783090
Első szerző:Márton Ildikó (fogszakorvos)
Cím:Salivary IL-6 mRNA is a Robust Biomarker in Oral Squamous Cell Carcinoma / Márton Ildikó Judit, Horváth József, Lábiscsák Péter, Márkus Bernadett, Dezső Balázs, Szabó Adrienn, Tar Ildikó, Piffkó József, Jakus Petra, Barabás József, Barabás Péter, Olasz Lajos, Kövér Zsanett, Tőzsér József, Sándor János, Csősz Éva, Scholtz Beáta, Kiss Csongor
Dátum:2019
ISSN:2077-0383
Megjegyzések:Salivary IL-6 mRNA was previously identified as a promising biomarker of oral squamous cell carcinoma (OSCC). We performed a multi-center investigation covering all geographic areas of Hungary. Saliva from 95 patients with OSCC and 80 controls, all Caucasian, were collected together with demographic and clinicopathological data. Salivary IL-6 mRNA was quantified by real-time quantitative PCR. Salivary IL-6 protein concentration was measured by enzyme-linked immune-sorbent assay. IL-6 protein expression in tumor samples was investigated by immunohistochemistry. Normalized salivary IL-6 mRNA expression values were significantly higher (p < 0.001) in patients with OSCC (mean ? SE: 3.301 ? 0.885) vs. controls (mean ? SE: 0.037 ? 0.012). Differences remained significant regardless of tumor stage and grade. AUC of the ROC curve was 0.9379 (p < 0.001; 95% confidence interval: 0.8973?0.9795; sensitivity: 0.945; specificity: 0.819). Salivary IL-6 protein levels were significantly higher (p < 0.001) in patients (mean ? SE: 70.98 ? 14.06 pg/mL), than in controls (mean ? SE: 12.45 ? 3.29). Specificity and sensitivity of IL-6 protein were less favorable than that of IL-6 mRNA. Salivary IL-6 mRNA expression was significantly associated with age and dental status. IL-6 manifestation was detected in tumor cells and tumor-infiltrating leukocytes, suggesting the presence of a paracrine loop of stimulation. Salivary IL-6 mRNA is one of the best performing and clinically relevant biomarkers of OSCC.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
salivary biomarkers
oral neoplasia
periodontal disease/periodontitis
smoking
ethanol consumption
real-time quantitative PCR
enzyme-linked immune-sorbent assay
immunohistochemistry
Megjelenés:Journal of Clinical Medicine. - 8 : 11 (2019), p. 1-12. -
További szerzők:Horváth József (1987-) (molekuláris genetikus) Lábiscsák Péter Márkus Bernadett (1989-) (molekuláris biológus) Dezső Balázs (1951-) (pathológus) Szabó Adrienn (1980-) (arc-, állcsont- és szájsebész) Tar Ildikó (1967-) (fogszakorvos) Piffkó József Jakus Petra Barabás József Barabás Péter Olasz Lajos Kövér Zsanett Tőzsér József (1959-) (molekuláris biológus, biokémikus, vegyész) Sándor János (1966-) (orvos-epidemiológus) Csősz Éva (1977-) (biokémikus, molekuláris biológus) Scholtz Beáta (1967-) (biokémikus, molekuláris biológus) Kiss Csongor (1956-) (hematológus, onkológus)
Pályázati támogatás:OTKA 105034
Egyéb
János Bolyai Scholarship of the Hungarian Academy of Sciences
Egyéb
ÚNKP-18-4-DE-436
Egyéb
Internet cím:Szerző által megadott URL
DOI
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2.

001-es BibID:BIBFORM117874
035-os BibID:(cikkazonosító)448 (Scopus)85183407744
Első szerző:Tar Ildikó (fogszakorvos)
Cím:Six-Month Follow-Up of Periodontal Condition in Rheumatoid Arthritis and Ankylosing Spondylitis Arthritis Patients Undergoing Anti-Tumour Necrosis Factor-alpha Therapy / Ildikó Tar, Edit Végh, Renáta Martos, Boglárka Soós, Ildikó Márton, Zoltán Szekanecz
Dátum:2024
ISSN:2077-0383
Megjegyzések:In our present study, we aimed to assess the effects of anti-TNF therapy on periodontal condition in a mixed cohort of patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Moreover, we wished to determine whether the baseline dental condition of these patients would affect response to biological therapy. A cohort of 24 arthritis patients was consecutively recruited before starting anti-TNF? therapy. After the dropout of six patients, we evaluated the dental status of 18 subjects at baseline and after 6 months of biological therapy. Clinical responder (R) and non-responder (NR) status was determined after 6 months of anti-TNF treatment. Plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD), PPDmax, clinical attachment loss (CAL), and CALmax were determined. During the 6-month treatment period, six patients (3 RA and 3 AS) terminated the study prematurely as they did not respond to treatment (NR). Therefore, 18 patients were included in the full analysis. There were no major differences in PI, BOP, PPD, PPD max, CAL, and CALmax, among R and NR patients. TNF inhibition resulted in increased GI (0.65 ? 0.34 vs. 0.88 ? 0.30; p < 0.05), as well as decreased PPDmax (4 ? 1.94 vs. 2.72 ? 1.36; p < 0.05) and CALmax (5.22 ? 2.56 vs. 2.72 ? 1.36; p < 0.05) after 6 months. Eight patients had incomplete canal fillings or dead pulps and/or apical periodontitis; six in the R and two in the NR group. In our present study, anti-TNF therapy seemed to worsen the extent of gingival inflammation (GI); however our results also do not support the reduction of mean CPD and CAL as reported by others
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
rheumatoid arthritis
ankylosing spondylitis
periodontitis
anti-TNF treatment
Megjelenés:Journal of Clinical Medicine. - 13 : 2 (2024), p. 1-10. -
További szerzők:Végh Edit (1978-) (reumatológus, belgyógyász) Martos Renáta (1975-) (fogszakorvos) Soós Boglárka (1988-) (általános orvos) Márton Ildikó (1954-) (fogszakorvos) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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