Találati lista | Tudóstér

001-es BibID:	BIBFORM080730
035-os BibID:	(cikkazonosító)2084 (WoS)000487964600293 (Scopus)85071762937 (PMID)31487780
Első szerző:	Aydemir, Gamze (biotechnológus)
Cím:	Apo-14'-Carotenoic Acid Is a Novel Endogenous and Bioactive Apo-Carotenoid / Gamze Aydemir, Marta Domínguez, Angel R. de Lera, Johanna Mihaly, Dániel Törőcsik, Ralph Rühl
Dátum:	2019
ISSN:	2072-6643
Megjegyzések:	Carotenoids can be metabolized to various apo-carotenoids and retinoids. Apo-15?-carotenoic acid (retinoic acid, RA) is a potent activator of the retinoic acid receptor (RAR) in its all-trans- (ATRA) and 9-cis- (9CRA) forms. In this study we show firstly, that apo-14?-carotenoic acid (A14CA), besides retinoic acids, is present endogenously and with increased levels in the human organism after carrot juice supplementation rich in β-carotene. All-trans-A14C (ATA14CA) is just a moderate activator of RAR-transactivation in reporter cell lines but can potently activate retinoic acid response element (RARE)-mediated signalling in DR5/RARE-reporter mice and potently increase retinoid-reporter target gene expression in ATA14CA-supplemented mice and treated MM6 cells. Further metabolism to all-trans-13,14-dihydroretinoic acid (ATDHRA) may be the key for its potent effects on retinoid target gene activation in ATA14CA-treated MM6 cells and in liver of supplemented mice. We conclude that besides RAs, there are alternative ways to activate RAR-response pathways in the mammalian organism. ATA14CA alone and in combination with its metabolite ATDHRA may be an alternative pathway for potent RAR-mediated signalling.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk apo-carotenoids carotene retinoic acid vitamin A
Megjelenés:	Nutrients. - 11 : 9 (2019), p. 1-11. -
További szerzők:	Domínguez, Marta de Lera, Ángel R. Mihály Johanna (1982-) (biológus, vegyész) Töröcsik Dániel (1979-) (bőrgyógyász) Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
Borító:
Saját polcon:

001-es BibID:	BIBFORM065683
Első szerző:	Aydemir, Gamze (biotechnológus)
Cím:	Lycopene supplementation restores vitamin A deficiency in mice and possesses thereby partial pro-vitamin A activity transmitted via RAR-signaling / Gamze Aydemir, Yasamin Kasiri, Emöke-Márta Bartók, Eszter Birta, Kati Fröhlich, Volker Böhm, Johanna Mihaly, Ralph Rühl
Dátum:	2016
ISSN:	1613-4125
Megjegyzések:	SCOPE:The aim of this study was to compare if lycopene also possesses pro-vitamin A (VA) activity comparable to known VA derivatives.MATERIALS AND METHODS:We used a transgenic retinoic acid response element reporter mouse model (n = 8, per group) for this study, and after the initial wash out of VA using a vitamin A deficient diet (VAD) for 18 weeks, the animals were supplemented further with (a) VAD-fed mice, (b) VAD-fed mice plus retinol (20 mg/kg bw), (c) VAD-fed mice plus ?-carotene (40 mg/kg bw), and (d) VAD-fed mice plus lycopene (40 mg/kg bw). Using ex vivo scanning and gene expression analysis of retinoid target and VA marker gene analysis in various organs of these supplemented mice (b, c, d), we found increased luciferase activity and normalized marker and target gene analysis compared to group a.CONCLUSIONS:Lycopene can restore VA deficiency and compensate VA for retinoic acid receptor (RAR)-mediated signaling as the major function of VA in the mammalian organism. Lycopene administration can initiate upregulation of RAR-mediated signaling in various organs in VAD-fed animals via potential novel bioactive lycopene metabolites. This indicates that lycopene possesses partial pro-VA activity in mice transmitted via RAR-mediated signaling.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Carotenoid Retinoic acid receptor Retinol Tomato
Megjelenés:	Molecular Nutrition & Food Research 60 : 11 (2016), p. 2413-2420. -
További szerzők:	Kasiri, Yasamin Bartók Emőke Márta Birta Eszter Fröhlich Kati Böhm, Volker Mihály Johanna (1982-) (biológus, vegyész) Rühl, Ralph (1969-) (vegyész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM065885
035-os BibID:	(WoS)000392177600021 (Scopus)85009754053
Első szerző:	Landrier, J. F.
Cím:	Reduced adiponectin expression after high-fat diet is associated with selective up-regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue / Jean-Francois Landrier, Elnaz Kasiri, Esma Karkeni, Johanna Mihály, Gabriella Béke, Kathrin Weiss, Renata Lucas, Gamze Aydemir, Jérome Salles, Stéphane Walrand, Ángel R. de Lera, Ralph Rühl
Dátum:	2017
ISSN:	0892-6638
Megjegyzések:	Adiponectin is an adipocyte-derived adipokine with potent antidiabetic, anti-inflammatory, and antiatherogenic activity. Long-term, high-fat diet results in gain of body weight, adiposity, further inflammatory-based cardiovascular diseases, and reduced adiponectin secretion. Vitamin A derivatives/retinoids are involved in several of these processes, which mainly take place in white adipose tissue (WAT). In this study, we examined adiponectin expression as a function of high dietary fat and high vitamin A conditions in mice. A decrease of adiponectin expression in addition to an up-regulation of aldehyde dehydrogenase A1 (ALDH1A1), retinoid signaling, and retinoic acid response element signaling was selectively observed in WAT of normal vitamin A- and high-fat diet-fed mice. Reduced adiponectin expression in WAT was also observed in high vitamin A diet-fed mice. Adipocyte cell culture revealed that endogenous and synthetic retinoic acid receptor (RAR)?- and RAR?-selective agonists, as well as a synthetic retinoid X receptor agonist, efficiently reduced adiponectin expression, whereas ALDH1A1 expression only increased with RAR agonists. We conclude that reduced adiponectin expression under high-fat dietary conditions is dependent on i) increased ALDH1A1 expression in adipocytes, which does not increase all-trans-retinoic acid levels; ii) further RAR ligand-induced, WAT-selective, increased retinoic acid response element-mediated signaling; and iii) RAR ligand-dependent reduction of adiponectin expression
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk vitamin A nuclear hormone receptor obesity diabetes retinaldehyde dehydrogenase
Megjelenés:	Faseb Journal. - 31 : 1 (2017), p. 203-211. -
További szerzők:	Kasiri, Elnaz Karkeni, Esma Mihály Johanna (1982-) (biológus, vegyész) Béke Gabriella (1987-) (molekuláris biológus) Weiss, Kathrin (1978-) Lucas, Renata Aydemir, Gamze (1977-) (biotechnológus) Salles, Jérome Walrand, Stéphane de Lera, Ángel R. Rühl, Ralph (1969-) (vegyész)
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat DOI
Borító:
Saját polcon:

001-es BibID:	BIBFORM042253
Első szerző:	Mihály Johanna (biológus, vegyész)
Cím:	Reduced retinoid signaling in the skin after systemic retinoid-X receptor ligand treatment in mice with potential relevance for skin disorders / Johanna Mihály, Janine Gericke, Gamze Aydemir, Kathrin Weiss, Harald Carlsen, Rune Blomhoff, Javier Garcia, Ralph Rühl
Dátum:	2012
ISSN:	1018-8665
Megjegyzések:	Retinoid-X receptor (RXR)- and retinoic acid receptor (RAR)-mediated signaling is induced by retinoic acids (RA), which are involved in the regulation of skin permeability, differentiation and immune response. Dysregulation of retinoid signaling is present in various skin disorders. Topically and systemically administered synthetic RAR or RXR agonists might influence retinoid-mediated signaling in the skin of RARE reporter animals and gene expression analysis for retinoid, skin homeostasis and skin inflammation marker genes and local retinoid concentrations. Mice were treated orally and topically with synthetic ligands and bioimaging, QRT-PCR and retinoid analysis were performed. Topical application of the synthetic RAR ligand AM580 significantly enhanced retinoid signaling in skin while topical application of the RXR ligand LG268 did not influence retinoic acid receptor response elements (RARE)-mediated signaling. Systemic treatments with LG268 decreased the expression of genes involved in skin homeostasis, RA synthesis and skin RA concentrations, while it increased various markers for skin inflammation and RA degradation, which corresponds to decreased skin RARE signaling. We conclude from these observations that increased systemic concentrations of an RXR -ligand may be one reason for reduced retinoid signaling, -reduced all-trans RA levels in the skin, reduced epidermal homeostasis and increased skin inflammation marker expression with potential relevance for various skin disorders, like atopic dermatitis.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Molekuláris Medicina
Megjelenés:	Dermatology. - 225 : 4 (2012), p. 304-311. -
További szerzők:	Gericke, Janine (1982-) (táplálkozástudományi szakember) Aydemir, Gamze (1977-) (biotechnológus) Weiss, Kathrin (1978-) Carlsen, Harald Blomhoff, Rune Garcia, Javier Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:	TÁMOP-4.2.1./B-09/1/KONV-2010-007 TÁMOP Magreceptorok szerepe a sejtdifferenciacioban es metabolikus folyamatokban TÁMOP-4.2.2.A-11/1/KONV-2012-0023 TÁMOP COST projects ♭Mast Cells and Basophils ? Targets for innovative therapies' and ♭SkinBAD'. Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: