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001-es BibID:BIBFORM075081
Első szerző:Bohn, Torsten
Cím:Proteomic responses of carotenoid and retinol administration to Mongolian gerbils / Bohn Torsten, Planchon Sébastien, Leclercq Céline C., Renaut Jenny, Mihaly Johanna, Beke Gabriella, Rühl Ralph
Dátum:2018
ISSN:2042-6496 2042-650X
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Food & Function. - 9 : 7 (2018), p. 3835-3844. -
További szerzők:Planchon, Sébastien Leclercq, Céline C. Renaut, Jenny Mihály Johanna (1982-) (biológus, vegyész) Béke Gabriella (1987-) (molekuláris biológus) Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:K109362
OTKA
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2.

001-es BibID:BIBFORM065885
035-os BibID:(WoS)000392177600021 (Scopus)85009754053
Első szerző:Landrier, J. F.
Cím:Reduced adiponectin expression after high-fat diet is associated with selective up-regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue / Jean-Francois Landrier, Elnaz Kasiri, Esma Karkeni, Johanna Mihály, Gabriella Béke, Kathrin Weiss, Renata Lucas, Gamze Aydemir, Jérome Salles, Stéphane Walrand, Ángel R. de Lera, Ralph Rühl
Dátum:2017
ISSN:0892-6638
Megjegyzések:Adiponectin is an adipocyte-derived adipokine with potent antidiabetic, anti-inflammatory, and antiatherogenic activity. Long-term, high-fat diet results in gain of body weight, adiposity, further inflammatory-based cardiovascular diseases, and reduced adiponectin secretion. Vitamin A derivatives/retinoids are involved in several of these processes, which mainly take place in white adipose tissue (WAT). In this study, we examined adiponectin expression as a function of high dietary fat and high vitamin A conditions in mice. A decrease of adiponectin expression in addition to an up-regulation of aldehyde dehydrogenase A1 (ALDH1A1), retinoid signaling, and retinoic acid response element signaling was selectively observed in WAT of normal vitamin A- and high-fat diet-fed mice. Reduced adiponectin expression in WAT was also observed in high vitamin A diet-fed mice. Adipocyte cell culture revealed that endogenous and synthetic retinoic acid receptor (RAR)?- and RAR?-selective agonists, as well as a synthetic retinoid X receptor agonist, efficiently reduced adiponectin expression, whereas ALDH1A1 expression only increased with RAR agonists. We conclude that reduced adiponectin expression under high-fat dietary conditions is dependent on i) increased ALDH1A1 expression in adipocytes, which does not increase all-trans-retinoic acid levels; ii) further RAR ligand-induced, WAT-selective, increased retinoic acid response element-mediated signaling; and iii) RAR ligand-dependent reduction of adiponectin expression
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
vitamin A
nuclear hormone receptor
obesity
diabetes
retinaldehyde dehydrogenase
Megjelenés:Faseb Journal. - 31 : 1 (2017), p. 203-211. -
További szerzők:Kasiri, Elnaz Karkeni, Esma Mihály Johanna (1982-) (biológus, vegyész) Béke Gabriella (1987-) (molekuláris biológus) Weiss, Kathrin (1978-) Lucas, Renata Aydemir, Gamze (1977-) (biotechnológus) Salles, Jérome Walrand, Stéphane de Lera, Ángel R. Rühl, Ralph (1969-) (vegyész)
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3.

001-es BibID:BIBFORM113874
035-os BibID:(cikkazonosító)11264 (WoS)001038615500001 (scopus)85165955959
Első szerző:Lendvai Alexandra (PhD hallgató)
Cím:N,N-Dimethylglycine Sodium Salt Exerts Marked Anti-Inflammatory Effects in Various Dermatitis Models and Activates Human Epidermal Keratinocytes by Increasing Proliferation, Migration, and Growth Factor Release / Lendvai Alexandra, Béke Gabriella, Hollósi Erika, Becker Maike, Völker Jörn Michael, Schulze zur Wiesche Erik, Bácsi Attila, Bíró Tamás, Mihály Johanna
Dátum:2023
ISSN:1422-0067
Megjegyzések:N,N-dimethylglycine (DMG) is a naturally occurring compound being widely used as an oral supplement to improve growth and physical performance. Thus far, its effects on human skin have not been described in the literature. For the first time, we show that N,N-dimethylglycine sodium salt (DMG-Na) promoted the proliferation of cultured human epidermal HaCaT keratinocytes. Even at high doses, DMG-Na did not compromise the cellular viability of these cells. In a scratch wound-closure assay, DMG-Na augmented the rate of wound closure, demonstrating that it promotes keratinocyte migration. Further, DMG-Na treatment of the cells resulted in the upregulation of the synthesis and release of specific growth factors. Intriguingly, DMG-Na also exerted robust anti inflammatory and antioxidant effects, as assessed in three different models of human keratinocytes, mimicking microbial and allergic contact dermatitis as well as psoriasis and UVB irradiation-induced solar dermatitis. These results identify DMG-Na as a highly promising novel active compound to promote epidermal proliferation, regeneration, and repair, and to exert protective functions. Further preclinical and clinical studies are under investigation to prove the seminal impact of topically applied DMG-Na on relevant conditions of the skin and its appendages.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:International Journal Of Molecular Sciences. - 24 : 14 (2023), p. 1-18. -
További szerzők:Béke Gabriella (1987-) (molekuláris biológus) Hollósi Erika Becker, Maike Völker, Jörn Michael Schulze zur Wiesche, Erik Bácsi Attila (1967-) (immunológus) Bíró Tamás (1968-) (élettanász) Mihály Johanna (1982-) (biológus, vegyész)
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4.

001-es BibID:BIBFORM074173
035-os BibID:(WOS)000431498600282
Első szerző:Miltner Noémi (molekuláris biológus)
Cím:Assessment of the anti-inflammatory effects of cannabidiol and its fluorinated derivative in in vitro and in vivo models of atopic dermatitis / Miltner Noémi, Béke Gabriella, Angyal Ágnes, Kemény Ágnes, Pintér Erika, Helyes Zsuzsanna, Bíró Tamás, Mihály Johanna
Dátum:2018
ISSN:0022-202X 1523-1747
Megjegyzések:Noémi Miltner1, Gabriella Béke1, Ágnes Angyal1, Ágnes Kemény2, Erika Pintér2, Zsuzsanna Helyes2, Tamás Bíró1,3, Johanna Mihály1Assessment of the anti-inflammatory effects of cannabidiol and its fluorinated derivative in in vitro and in vivo models of atopic dermatitis1Department of Immunology, Faculty of Medicine, University of Debrecen, Hungary2Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pécs, Hungary3Phytecs Inc., Los Angeles, CA, USAIt is common wisdom in pharmacology that fluorination can significantly increase the efficacy of the active components in pharmaceuticals ? actually, ca. 30% of the best-selling drugs worldwide contain fluorinated compounds. The aim of the current study was to assess the potential anti-inflammatory effects of cannabidiol (CBD), the major non-psychoactive component of the pant Cannabis sativa, and its fluorinated derivative (HUF-101) in various experimental systems modeling atopic dermatitis (AD). For the in vitro AD model, human epidermal keratinocytes were challenged with the combination of Staphylococcus aureus enterotoxin B (SEB) and thymic stromal lymphopoietin (TSLP), and expressions of certain marker molecules were assessed by RT-qPCR and ELISA. For the in vivo model, mice were sensitized with 2% oxazolone (OXA) before elicitation. Test compounds were applied topically (1 and 10 ?M) after inducing skin inflammation and edema formation (in the ears) was measured with an engineer's micrometer.In the in vitro model, expressions of certain pro-inflammatory cytokines (e.g. interleukin [IL]-1?, IL-1?, IL-6 and IL-8) were significantly down-regulated upon the administration of CBD and HUF-101. Of great importance, however, HUF-101 exhibited significantly higher potency in comparison to CBD. In the in vivo model, topical application of 1 ?M CBD significantly reduced the OXA-induced ear edema; however, 10 ?M CBD exerted insignificant effect. In contrast, HUF-101 attenuated OXA-induced edema formation at both concentrations. Intriguingly, similar to the in vitro conditions, the anti-inflammatory potency of HUF-101 was significantly greater than that of CBD. Our study provides the first evidence that CBD and its fluorinated derivative exert significant anti-inflammatory actions in models of AD. These intriguing data invite further pre-clinical and clinical studies to exploit the therapeutic potential of certain CBD derivatives in cutaneous inflammatory conditions.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Journal of Investigative Dermatology. - 138 : 5S (2018), p. S173. -
További szerzők:Béke Gabriella (1987-) (molekuláris biológus) Angyal Ágnes (1987-) (molekuláris biológus) Kemény Ágnes Pintér Erika Helyes Zsuzsanna Bíró Tamás (1968-) (élettanász) (absztraktok) Mihály Johanna (1982-) (biológus, vegyész)
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5.

001-es BibID:BIBFORM071068
035-os BibID:(WOS)000423029700020 (Scopus)85041655428
Első szerző:Szöllősi Attila Gábor (élettanász)
Cím:Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes / Szöllősi A. G., Vasas N., Angyal Á., Kistamás K., Nánási P. P., Mihály J., Béke G., Herczeg-Lisztes E., Szegedi A., Kawada N., Yanagida T., Mori T., Kemény L., Bíró T.
Dátum:2018
Megjegyzések:Transient receptor potential (TRP) ion channels were first characterized on neurons, where they are classically implicated in sensory functions; however, research in recent decades has shown that many of these channels are also expressed on non-neuronal cell types. Emerging findings have highlighted the role of TRP channels in the skin, where they have been shown to be important in numerous cutaneous functions. Of particular interest is TRPV3, which was first described on keratinocytes. Its functional importance was supported when its gain-of-function mutation was linked to Olmsted syndrome, which is characterized by palmoplantar keratoderma, periorifacial hyperkeratosis, diffuse hypotrichosis and alopecia, as well as itch. In spite of these exciting results, we have no information about the role and functionality of TRPV3 on keratinocytes at the cellular level. In our current study, we have identified TRPV3 expression both on human skin and cultured epidermal keratinocytes. TRPV3 stimulation was found to function as a Ca2+-permeable ion channel which suppresses proliferation of epidermal keratinocytes and induces cell death. Stimulation of the channel also triggers a strong proinflammatory response via the NF-?B pathway. Collectively our data shows that TRPV3 is functionally expressed on human epidermal keratinocytes and that it plays a role in cutaneous inflammatory processes.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
inflammation
keratinocyte
nuclear factor kappa-light-chain-enhancer of activated B cells
transient receptor potential vanilloid
Megjelenés:Journal of Investigative Dermatology. - 138 : 2 (2018), p. 365-374. -
További szerzők:Molnárné Vasas Nikolett (1987-) (élettanász) Angyal Ágnes (1987-) (molekuláris biológus) Kistamás Kornél (1986-) (biológus) Nánási Péter Pál (1956-) (élettanász) Mihály Johanna (1982-) (biológus, vegyész) Béke Gabriella (1987-) (molekuláris biológus) Lisztes Erika (1986-) (élettanász) Szegedi Andrea (1964-) (bőrgyógyász) Kawada, Naoki Yanagida, Takashi Mori, Tomohiro Kemény Lajos Bíró Tamás (1968-) (élettanász)
Pályázati támogatás:OTKA 105369
OTKA
NKFIH K120552
Egyéb
NKFIH K120187
Egyéb
GINOP-2.3.2-15-2016-00015
GINOP
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