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1.

001-es BibID:BIBFORM046502
Első szerző:Pálvölgyi Attila
Cím:Interplay between nitric oxide and VIP in CCK-8-induced phasic contractile activity in the rabbit sphincter of Oddi / Attila Pálvölgyi, Réka Sári, József Németh, Annamária Szabolcs, István Nagy, Péter Hegyi, János Lonovics, Zoltán Szilvássy
Dátum:2005
ISSN:1007-9327
Megjegyzések:AIM: The sphincter of Oddi (SO) plays an important role indelivery of bile into the duodenum. To establish whethervasoactive intestinal polypeptide (VIP) and nitric oxide (NO)were involved in phasic contractile activity of the rabbitSO stimulated by cholecystokinin-octapeptide (CCK-8).METHODS: Isolated SO muscle rings were cleaned of fatand mounted horizontally on two small L-shaped hooksone of which was connected to a force transducer for themeasurement of isometric tension. The experiments werecarried out in a thermostatically controlled (37?0.2 )organ bath (5 mL) containing Krebs solution. The organfluid was gassed with 95% O2 and 50 mL/L CO2 to keepthe pH at 7.40?0.05. Contractile responses to CCK-8(1 ?mol/L) were evaluated in the presence and absenceof NG-nitro-L-arginine (LNNA), an inhibitor of NO synthase(100 ?mol/L), and (p-chloro-D-Phe6-Leu17)-VIP (VIPa,30 ?mol/L), a VIP receptor antagonist.RESULTS: CCK-8 stimulated the phasic activity of the SO.NO synthase inhibition increased the frequency and amplitudeof contractions with a slight increase in developed tension.Pre-incubation with VIPa also attenuated this CCK-8 effect.The combined application of LNNA and VIPa abolishedthe phasic activity of the muscle rings with a marked increasein tension in response to CCK-8.CONCLUSION: VIP and NO together contribute to anincrease in phasic activity of SO.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Sphincter of Oddi
CCK
VIP
NO
LNNA
Megjelenés:World Journal of Gastroenterology. - 11 : 21 (2005), p. 3264-3266. -
További szerzők:Sári Réka (farmakológus) Németh József (Pécs) Szabolcs Annamária Nagy István Hegyi Péter Jenő (belgyógyász) Lonovics János (Szeged) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
Pályázati támogatás:3.2.2.-2004-07-0001/3.0
GVOP
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2.

001-es BibID:BIBFORM046503
035-os BibID:PMID:15526367
Első szerző:Sári Réka (farmakológus)
Cím:Ethanol inhibits the motility of rabbit sphincter of Oddi in vitro / Réka Sári, Attila Pálvölgyi, Zoltán Rakonczay Jr, Tamás Takács, János Lonovics, László Czakó, Zoltán Szilvássy, Péter Hegyi
Dátum:2004
ISSN:1007-9327
Megjegyzések:AIM: The role of the sphincter of Oddi (SO) in ethanol(ETOH)-induced pancreatitis is controversial. Our aim wasto characterise the effect of ETOH on basal and stimulatedSO motility.METHODS: SOs removed from white rabbits were placedin an organ bath (Krebs solution, pH7.4, 37 ). The effectsof 2 mL/L, 4 mL/L, 6 mL/L and 8 mL/L of ETOH on thecontractile responses of the sphincter were determined.SOs were stimulated with either 0.1 ?mol/L carbachol, 1?mol/L erythromycin or 0.1 ?mol/L cholecystokinin (CCK).RESULTS: ETOH at a dose of 4 mL/L significantly decreasedthe baseline contractile amplitude from 11.98?0.05 mN to11.19?0.07 mN. However, no significant changes in thecontractile frequency were observed. ETOH (0.6%)significantly decreased both the baseline amplitude and thefrequency compared to the control group (10.50?0.01 mN,12.13?0.10 mN and 3.53?0.13 c/min, 5.5?0.13 cycles(c)/min,respectively). Moreover, 0.8% of ETOH resulted in completerelaxation of the SO. Carbachol (0.1 ?mol/L) or erythromycin(1 ?mol/L) stimulated the baseline amplitudes (by 82%and 75%, respectively) and the contractile frequencies(by 150% and 106%, respectively). In the carbachol orerythromycin-stimulated groups 2-6 mL/L of ETOH significantlyinhibited both the amplitude and the frequency. Interestingly,a 4-5 min administration of 6 mL/L ETOH suddenly andcompletely relaxed the SO. CCK (0.1 ?mol/L) stimulatedthe baseline amplitude from 12.37?0.05 mN to 27.40?1.82mN within 1.60?0.24 min. After this peak, the amplitudedecreased to 17.17?0.22 mN and remained constant duringthe experiment. The frequency peaked at 12.8?0.2 c/min,after which the constant frequency was 9.43?0.24 c/minthroughout the rest of the experiment. ETOH at a doseof 4 mL/L significantly decreased the amplitude from16.13?0.23 mN to 14.93?0.19 mN. However, no significantchanges in the contractile frequency were observed. ETOHat a dose of 6 mL/L inhibited both the amplitudes and thefrequencies in the CCK-stimulated group, while 8 mL/L ofETOH completely relaxed the SO.CONCLUSION: ETOH strongly inhibits the basal, carbachol,erythromycin, and CCK-stimulated rabbit SO motility.Therefore, it is possible that during alcohol-intake therelaxed SO opens the way for pancreatic fluid to flow outinto the duodenum in rabbits. This relaxation of the SOmay protect the pancreas against alcohol-induced damage.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
ethanol
effect of ETOH
CCK-stimulated
SO
erythromycin
Megjelenés:World Journal of Gastroenterology. - 10 : 23 (2004), p. 3470-3474. -
További szerzők:Pálvölgyi Attila Rakonczay Zoltán Jr. Takács Tamás (Szeged) Lonovics János (Szeged) Czakó László Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Hegyi Péter Jenő (belgyógyász)
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3.

001-es BibID:BIBFORM020441
Első szerző:Sári Réka (farmakológus)
Cím:Impairment by lovastatin of neural relaxation of the rabbit sphincter of Oddi / Reka Sari, Jozsef Nemeth, Robert Porszasz, Peter Horvath, Ingolf E. Blasig, Peter Ferdinandy, Istvan Nagy, Janos Lonovics, Zoltan Szilvassy
Dátum:2001
Megjegyzések:AbstractWe sought whether inhibition of cholesterol biosynthesis by lovastatin influenced the nitrergic relaxation response of the sphincter of Oddi. Rabbit sphincters of Oddi rings were tested for changes in isometric tension in response to field stimulation in the presence of 4 microM guanethidine and 1 microM atropine. Tissue samples were then analyzed for cAMP and cGMP content by radioimmunoassay for nitric oxide concentration by electron spin resonance and for vasoactive intestinal peptide and calcitonin gene-related peptide (CGRP) release by radioimmunoassay. Membrane G(salpha) protein was determined by Western blot analysis. Field stimulation relaxed the preparations with an increase in nitric oxide, cAMP and cGMP concentrations at increased calcitonin gene-related peptide and vasoactive intestinal polypeptide (VIP) release. Preparations from rabbits pre-treated with lovastatin (5 mg/kg/day intragastrically, over 5 days) contracted under the same conditions with an attenuated cGMP-increase at preserved increase in NO content and neuropeptide release. The relaxation was recaptured combining lovastatin with farnesol (1 mg/kg intravenously, twice a day for 5 days). The field stimulation-induced increase in cyclic nucleotides was also restored. Lovastatin decreased membrane G(salpha) protein content, which was re-normalized by farnesol. Farnesol treatment reinstates neurogenic relaxation of the sphincter of Oddi deteriorated by lovastatin possibly by normalizing G-protein coupling.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Impairment by lovastatin
lovastatin
neural relaxation
Megjelenés:European Journal of Pharmacology. - 432 : 1 (2001), p. 91-97. -
További szerzők:Németh József (Pécs) Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus) Horváth Péter Blasig, Ingolf E. Ferdinándy Péter Nagy István (orvos) Lonovics János (Szeged) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
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DOI
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4.

001-es BibID:BIBFORM020340
Első szerző:Sári Réka (farmakológus)
Cím:Cyclic GMP-mediated activation of a glibenclamide-sensitive mechanism in the rabbit sphincter of Oddi / Reka Sari, Barna Peitl, Peter Kovacs, Janos Lonovics, Attila Palvolgyi, Peter Hegyi, Istvan Nagy, Jozsef Nemeth, Zoltan Szilvassy, Robert Porszasz
Dátum:2004
Megjegyzések:AbstractWe investigated whether glibenclamide-sensitive potassium channels are involved in cyclic GMP (cGMP)-mediated relaxation of the rabbit Oddi's sphincter. Changes in isometric tension were measured in the presence of atropine (1 microM) and guanethidine (4 microM). Concentration-response curves for nitroglycerin, vasoactive intestinal polypeptide (VIP), and sodium nitroprusside (SNP) were shifted to the right in the presence of (p-chloro-D-Phe6, Leu17)-VIP (VIPa), a VIP receptor antagonist. Glibenclamide (1 microM) attenuated the relaxations to VIP, nitroglycerin, or 8-bromo cGMP. In the presence of tetrodotoxin (TTX), glibenclamide attenuated relaxations to VIP without effect on those to nitroglycerin. Furthermore, nitroglycerin increased both cAMP and cGMP concentrations, however, it failed to increase the tissue cAMP concentration in the presence of TTX. VIPa also blocked the increase in content of either cyclic nucleotide. VIP increased cAMP with a TTX-sensitive increase in cGMP content. 8-Bromo cGMP (1 microM) significantly increased the tissue cAMP content. This was blocked by either TTX or VIPa (both 1 microM). We conclude that ATP-sensitive potassium channel (KATP) activation contributes to cGMP-mediated relaxation of the Oddi's sphincter of the rabbit. Activation of KATP results from a cyclic AMP-mediated process due to cGMP-dependent VIP release from neurons.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Cyclic GMP
GMP-Mediated Activation
Glibenclamide-Sensitive
Megjelenés:Digestive Diseases and Sciences. - 49 : 3 (2004), p. 514-520. -
További szerzők:Peitl Barna (1972-) (orvos, farmakológus) Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Lonovics János (Szeged) Pálvölgyi Attila Hegyi Péter Jenő (belgyógyász) Nagy István (orvos) Németh József (Pécs) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus)
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5.

001-es BibID:BIBFORM020575
Első szerző:Sári Réka (farmakológus)
Cím:Cross tolerance between nitroglycerin and neural relaxation of the rabbit sphincter of Oddi / Réka Sári, Zoltán Szilvássy, Ildikó Jakab, István Nagy, János Lonovics
Dátum:1998
ISSN:1043-6618
Megjegyzések:Szegedi Tudományegyetem - Belgyógyászati Klinika
We studied whether non-adrenergic, non-cholinergic (NANC) relaxation of the rabbit sphincter of Oddi was influenced by tolerance to nitroglycerin (NG)in vitro. Sphincter of Oddi (SO) muscle rings precontracted with EC50concentrations of cholecystokinin octapeptide (CCK8) were exposed to cumulative increases in NG concentrations and tested for relaxation by measurement of isometric tension. A separate group of six rings was subjected to a preceding exposure to 275 mnitroglycerin over 60 min to inducein vitrotolerance to nitroglycerin. The rings (both tolerant and non-tolerant) were subjected to electrical field stimulation (FS: 50 V, 0.1 ms, 20 Hz, 3 and 10 stimuli). The rings were then preincubated with NANC solution: phentolamine, oxprenolol and atropine (all 1 m) for 20 min and FS was applied again. FS was repeated after additional incubation withNG-nitro-l-arginine methyl ester (l-NAME), an inhibitor of NO synthase (30 m) and after a successive incubation with 3 mml-arginine (20 min). Maximum contractions produced by CCK8 in `tolerant' and 'non-tolerant' sphincters were 29.9±5.8 and 28.3±5.2 mN, respectively. The sensitivity to CCK8 also was not different between the two groups with EC50(-log M) values of 8.5±0.2 and 8.3±0.1, respectively. FS evoked twitchlike contraction followed by relaxation in the ampullary SO in both `tolerant' and `non-tolerant' preparations. Incubation in NANC solution resulted in monophasic relaxations in response to FS in non-tolerant sphincters but not in tolerant ones.l-NAME (30 m) reversed NANC relaxation in non-tolerant muscle rings whereas it failed to modify NANC contractions in the tolerant preparations.l-arginine (3 mm) reversed the inhibitory effect ofl-NAME on NANC relaxation in the `non-tolerant' rings and it was without effect on FS-induced contractions in the `tolerant' SO. As measured by radioimmunoassay, tolerance to NG was without any significant effect on tissue content of both cyclic adenosine 3:5 monophosphate (cAMP) and cyclic guanosine 3:5 monophosphate (cGMP). FS significantly increased tissue cAMP and cGMP content in 'non-tolerant' preparations. FS failed to increase the level of either cyclic nucleotide in `tolerant' tissue. We conclude that NANC relaxation of the ampullary part of the rabbit SO is significantly impaired in the state of tolerance to NG`in vitro'.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
cross tolerance
nitroglycerin
neural relaxation
Megjelenés:Pharmacological Research. - 37 : 6 (1998), p. 505-512. -
További szerzők:Jakab Ildikó (farmakológus) Nagy István Lonovics János (Szeged) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
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6.

001-es BibID:BIBFORM020269
Első szerző:Szilvássy Judit (fül- orr- gégész)
Cím:Neurogenic insulin resistance in guinea-pigs with cisplatin-induced neuropathy / Judit Szilvássy, István Sziklai, Réka Sári, József Németh, Barna Peitl, Robert Porszasz, János Lonovics, Zoltán Szilvássy
Dátum:2006
Megjegyzések:The aim of the present work was to study whether neurotoxicity produced by cisplatin modified tissue insulin sensitivity in guinea-pigs. One week after selective sensory denervation of the anterior hepatic plexus by means of perineurial 2% capsaicin treatment, hyperinsulinaemic euglycaemic glucose clamp were performed to estimate insulin sensitivity in male guinea-pigs. The guinea-pigs underwent regional sensory denervation of the anterior hepatic plexus exhibited insulin resistance, whereas systemic capsaicin desensitization increased insulin sensitivity. Intraportal administration of L-nitro-arginine methyl ester (L-NAME decreased, whereas capsaicin increased insulin sensitivity. Neither atropine nor acetylcholine produced any significant effect. In animals with preceding regional capsaicin desensitization, none of the pharmacological maneuvers modified the resulting insulin resistant state. Cisplatin pretreatment induced sensory neuropathy and decreased insulin sensitivity. Insulin sensitivity did not change after either regional or systemic capsaicin desensitization in the cisplatin-treated animals. CGRP(8-37), a nonselective calcitonin gene-related peptide (CGRP) antagonist (50 microg/kg i.v.), significantly increased insulin sensitivity in normal animals but only a tendency to insulin sensitization was seen after cisplatin treatment. Cisplatin treatment, similar to regional capsaicin desensitization of the anterior hepatic plexus, produced a significant decrease in insulin-stimulated uptake of 2-deoxy-D [L-14C] glucose in cardiac and gastrocnemius muscle with no effect on percentage suppression of endogenous glucose production by hyperinsulinaemia. We conclude that the majority of cisplatin-induced insulin resistance is related to functional deterioration of the hepatic insulin sensitizing substance (HISS) mechanism.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
neurogenic insulin
insulin resistance
cisplatin-induced
neuropathy
Megjelenés:European Journal of Pharmacology. - 531 : 1-3 (2006), p. 217-225. -
További szerzők:Sziklai István (1954-) (fül-orr-gégész) Sári Réka (farmakológus) Németh József (1954-) (vegyész, analitikus) Peitl Barna (1972-) (orvos, farmakológus) Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus) Lonovics János (Szeged) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
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7.

001-es BibID:BIBFORM020568
Első szerző:Szilvássy Zoltán (belgyógyász, farmakológus, klinikai farmakológus)
Cím:Improvement of nitrergic relaxation by farnesol of the sphincter of Oddi from hypercholesterolaemic rabbits / Zoltan Szilvassy, Reka Sari, Jozsef Nemeth, Istvan Nagy, Sandor Csati, Janos Lonovics
Dátum:1998
Megjegyzések:AbstractField stimulation relaxed the rabbit sphincter of Oddi muscle rings after incubation with atropine (1 microM) and guanethidine (4 microM) with a threefold increase in tissue cyclic cGMP content, a response previously shown to be essentially nitrergic. Preparations from hypercholesterolaemic rabbits (1.5% dietary cholesterol load over 8 weeks increasing serum total cholesterol from pre-diet 1.4+/-0.3 to 22.6+/-3.8 mmol/l) exhibited contractions with no change in cyclic GMP content under the same conditions. The nitrergic relaxation was recaptured with a twofold increase in tissue cyclic GMP content in preparations from hypercholesterolaemic rabbits undergone a treatment with 30 microM/kg farnesol i.v. twice a day over the last 3 days of the dietary period. We conclude that farnesol treatment restores nitrergic relaxation of the sphincter of Oddi in hypercholesterolaemia.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
nitrergic relaxation
farnesol
hypercholesterolaemic
Megjelenés:European Journal of Pharmacology. - 353 : 1 (1998), p. 75-78. -
További szerzők:Sári Réka (farmakológus) Németh József (Pécs) Nagy István Csáti Sándor Lonovics János (Szeged)
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