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001-es BibID:	BIBFORM115032
035-os BibID:	(WoS)000610869000010 (Scopus)85096209629 (cikkazonosító)151630
Első szerző:	Oláh Tamás (élettanász)
Cím:	Comparative anatomy and morphology of the knee in translational models for articular cartilage disorders. Part II: Small animals / Tamás Oláh, Xiaoyu Cai, Jana Christin Michaelis, Henning Madry
Dátum:	2021
ISSN:	0940-9602
Megjegyzések:	Background Small animal models are critical to model the complex disease mechanisms affecting a functional joint leading to articular cartilage disorders. They are advantageous for several reasons and significantly contributed to the understanding of the mechanisms of cartilage diseases among which osteoarthritis. Methods Literature search in Pubmed. Results and discussion This narrative review summarizes the most relevant anatomical structural and functional characteristics of the knee (stifle) joints of the major small animal species, including mice, rats, guinea pigs, and rabbits compared with humans. Specific characteristics of each species, including kinematical gait parameters are provided and compared with the human situation. When placed in a proper context respecting their challenges and limitations, small animal models are important and appropriate models for articular cartilage disorders.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Small animal model knee human osteochondral unit articular cartilage subchondral bone range of motion
Megjelenés:	Annals Of Anatomy-Anatomischer Anzeiger. - 234 (2021), p. 151630. -
További szerzők:	Michaelis, Jana Christin Cai, Xiaoyu Cucchiarini, Magali Madry, Henning
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM114910
035-os BibID:	(WoS)000635677000012 (Scopus)85100454395 (cikkazonosító)151680
Első szerző:	Oláh Tamás (élettanász)
Cím:	Comparative anatomy and morphology of the knee in translational models for articular cartilage disorders. Part I: Large animals / Tamás Oláh, Xiaoyu Cai, Jana Christin Michaelis, Henning Madry
Dátum:	2021
ISSN:	0940-9602
Megjegyzések:	Background: The human knee is a complex joint, and affected by a variety of articular cartilage disorders. Large animal models are critical to model the complex disease mechanisms affecting a functional joint. Species-dependent differences highly affect the results of a pre-clinical study and need to be considered, necessitating specific knowledge not only of macroscopic and microscopic anatomical and pathological aspects, but also characteristics of their individual gait and joint movements. Methods: Literature search in Pubmed. Results and discussion: This narrative review summarizes the most relevant anatomical structural and functional characteristics of the knee (stifle) joints of the major translational large animal species, comprising dogs, (mini)pigs, sheep, goats, and horses in comparison with humans. Specific characteristics of each species, including kinematical gait parameters are provided. Considering these multifactorial dimensions will allow to select the appropriate model for answering the research questions in a clinically relevant fashion.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Large animal model Knee Human Osteochondral unit Articular cartilage Subchondral bone Range of motion
Megjelenés:	Annals Of Anatomy-Anatomischer Anzeiger. - 235 (2021), p. 151680. -
További szerzők:	Cai, Xiaoyu Michaelis, Jana Christin Madry, Henning
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM114887
035-os BibID:	(WOS)000806728200001 (Scopus)85131298379 (cikkazonosító)2201692
Első szerző:	Oláh Tamás (élettanász)
Cím:	Quantifying the Human Subchondral Trabecular Bone Microstructure in Osteoarthritis with Clinical CT / Tamás Oláh, Xiaoyu Cai, Liang Gao, Frédéric Walter, Dietrich Pape, Magali Cucchiarini, Henning Madry
Dátum:	2022
ISSN:	2198-3844
Megjegyzések:	Osteoarthritis (OA) is characterized by critical alterations of the subchondral bone microstructure, besides the well-known cartilaginous changes. Clinical computed tomography (CT) detection of quantitative 3D microstructural subchondral bone parameters is applied to monitor changes of subchondral bone structure in different stages of human OA and is compared with micro-CT, the gold standard. Determination by clinical CT (287 ?m resolution) of key microstructural parameters in tibial plateaus with mild-to-moderate and severe OA reveals strong correlations to micro-CT (35 ?m), high inter- and intraobserver reliability, and small relative differences. In vivo, normal, mild-to-moderate, and severe OA are compared with clinical CT (331 ?m). All approaches detect characteristic expanded trabecular structure in severe OA and fundamental microstructural correlations with clinical OA stage. Multivariate analyses at various in vivo and ex vivo imaging resolutions always reliably separate mild-to-moderate from severe OA (except mild-to-moderate OA from normal), revealing a striking similarity between 287 ?m clinical and 35 ?m micro-CT. Thus, accurate structural measurements using clinical CT with a resolution near the trabecular dimensions are possible. Clinical CT offers an opportunity to quantitatively monitor subchondral bone microstructure in clinical and experimental settings as an advanced tool of investigating OA and other diseases affecting bone architecture.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk 3D microstructure computed tomography microcomputed tomography multislice computed tomography osteoarthritis of knee subchondral bone
Megjelenés:	Advanced Science. - 9 : 23 (2022), p. 2201692. -
További szerzők:	Cai, Xiaoyu Gao, Liang Walter, Frédéric Pape, Dietrich Cucchiarini, Magali Madry, Henning
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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