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001-es BibID:	BIBFORM118410
035-os BibID:	(cikkazonosító)2300931 (Scopus)85168319047 (WOS)001049575600001
Első szerző:	Gao, Liang
Cím:	A Photopolymerizable Biocompatible Hyaluronic Acid Hydrogel Promotes Early Articular Cartilage Repair in a Minipig Model In Vivo / Liang Gao, Riccardo Beninatto, Tamás Oláh, Lars Goebel, Ke Tao, Rebecca Roels, Steffen Schrenker, Julianne Glomm, Jagadeesh K. Venkatesan, Gertrud Schmitt, Ebrar Sahin, Ola Dahhan, Mauro Pavan, Carlo Barbera, Alba Di Lucia, Michael D. Menger, Matthias W. Laschke, Magali Cucchiarini, Devis Galesso, Henning Madry
Dátum:	2023
ISSN:	2192-2640 2192-2659
Megjegyzések:	Articular cartilage defects represent an unsolved clinical challenge. Photopolymerizable hydrogels are attractive candidates supporting repair. This study investigates the short-term safety and efficacy of two novel hyaluronic acid (HA)-triethylene glycol (TEG)-coumarin hydrogels photocrosslinked in situ in a clinically relevant large animal model. It is hypothesized that HA-hydrogel-augmented microfracture (MFX) is superior to MFX in enhancing early cartilage repair, and that the molar degree of substitution and concentration of HA affects repair. Chondral full-thickness defects in the knees of adult minipigs are treated with either 1) debridement (No MFX), 2) debridement and MFX, 3) debridement, MFX, and HA hydrogel (30% molar derivatization, 30 mg mL?1 HA; F3) (MFX+F3), and 4) debridement, MFX, and HA hydrogel (40% molar derivatization, 20 mg mL?1 HA; F4) (MFX+F4). After 8 weeks postoperatively, MFX+F3 significantly improves total macroscopic and histological scores compared with all other groups without negative effects, besides significantly enhancing the individual repair parameters "defect architecture," "repair tissue surface" (compared with No MFX, MFX), and "subchondral bone" (compared with MFX). These data indicate that photopolymerizable HA hydrogels enable a favorable metastable microenvironment promoting early chondrogenesis in vivo. This work also uncovers a mechanism for effective HA-augmented cartilage repair by combining lower molar derivatization with higher concentrations.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk cartilage defects cartilage repairs hyaluronic acid hydrogels large animal model photo-crosslinkin
Megjelenés:	Advanced Healthcare Materials. - 12 : 26 (2023), p. 2300931. -
További szerzők:	Beninatto, Riccardo Oláh Tamás (1983-) (élettanász) Goebel, Lars Tao, Ke Roels, Rebecca Schrenker, Steffen Glomm, Julianne Venkatesan, Jagadeesh K. Schmitt, Gertrud Sahin, Ebrar Dahhan, Ola Pavan, Mauro Barbera, Carlo Lucia, Alba Di Menger, Michael D. Laschke, Matthias W. Cucchiarini, Magali Galesso, Devis Madry, Henning
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