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001-es BibID:	BIBFORM065982
Első szerző:	Szabó Zsuzsanna (biológus, biológia-kémia szakos középiskolai tanár)
Cím:	Expression of miRNA-21 and miRNA-221 in clear cell renal cell carcinoma (ccRCC) and their possible role in the development of ccRCC / Zsuzsanna Szabó, Krisztián Szegedi, Katalin Gombos, Choudhury Mahua, Tibor Flaskó, Kristóf Harda, Gábor Halmos
Dátum:	2016
ISSN:	1078-1439
Megjegyzések:	AIM:Clear cell renal cell carcinoma (ccRCC) is the third most common urological cancer after prostate and bladder cancer but has the highest rate of mortality affecting over 40% of patients. microRNAs (miRNAs) are small noncoding RNAs that have become potential biomarkers and molecular targets for cancer treatment. Molecular markers such as miRNAs may have a role in the diagnosis of ccRCC. In this study, we examined the expressions of miRNA-21 and miRNA-221 in renal cancer patients? tumor and adjacent paired normal tissues investigating the possible role of these miRNAs in the development of ccRCC.MATERIALS AND METHODS:Renal tumors (n = 24) and paired normal renal tissue (n = 24) samples, obtained from the Department of Urology, University of Debrecen, were analyzed for miRNA-21 and miRNA-221 expressions with quantitative real-time polymerase chain reaction.RESULTS:miRNA-21 and miRNA-221 expressions were significantly up-regulated in tumor specimens compared to normal tissue (P<0.05). miRNA-21 and miRNA-221 showed coexpression pattern in 19 (79.2%) cases of tumor samples and 8 (33.3%) cases of paired normal renal tissues. Increased miRNA pattern showed a positive correlation with pathological status of the patients.CONCLUSIONS:Expression of oncogenic miRNA-21 and miRNA-221 in human ccRCC tumor tissue samples compared to adjacent nontumorous tissues might suggest that these miRNAs are involved in the development of ccRCC.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban clear cell renal cell carcinoma (ccRCC) miRNA-21 miRNA-221
Megjelenés:	Urologic Oncology-Seminars And Original Investigations 34 : 12 (2016), p. 533.e21-533.e27. -
További szerzők:	Szegedi Krisztián (1981-) (orvos) Gombos Katalin Mahua, Choudhury Flaskó Tibor (1960-) (urológus) Harda Kristóf Máté (1989-) (gyógyszerész) Halmos Gábor (1962-) (gyógyszerész, receptorfarmakológus, experimentális onkológus)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0025 TÁMOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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