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001-es BibID:	BIBFORM093464
Első szerző:	Besenyei Tímea (reumatológus, belgyógyász)
Cím:	Selective Inhibition of Epigenetic Factors Provide Potential New Tools for Arthritis Therapy / Timea Besenyei, Júlia Kurkó, Katalin Mikecz, Tibor T. Glant, Tibor A. Rauch
Dátum:	2011
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	Arthritis & Rheumatism. - 63 : Suppl10 (2011), p. S751. -
További szerzők:	Kurkó Júlia Emese (1979-) (reumatológus) Mikecz Katalin Glant Tibor T. Rauch Tibor A.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM073625
Első szerző:	Egelston, Colt
Cím:	Suppression of dendritic cell maturation and T cell proliferation by synovial fluid myeloid cells from mice with autoimmune arthritis / Colt Egelston, Júlia Kurkó, Timea Besenyei, Beata Tryniszewska, Tibor A. Rauch, Tibor T. Glant, Katalin Mikecz
Dátum:	2012
ISSN:	0004-3591 1529-0131
Megjegyzések:	OBJECTIVE:To determine whether myeloid cells (such as granulocytes) present in the synovial fluid (SF) of arthritic joints have an impact on adaptive immunity. Specifically, we investigated the effects of SF cells harvested from the joints of mice with proteoglycan-induced arthritis (PGIA), on dendritic cell (DC) maturation and antigen-specific T cell proliferation.METHODS:We monitored DC maturation (MHCII and CD86 expression) by flow cytometry upon coculture of DCs with SF cells or spleen myeloid cells from mice with PGIA. The effects of these myeloid cells on T cell proliferation were studied using T cells purified from PG-specific T cell receptor (TCR)-transgenic (Tg) mice. Phenotype analysis of myeloid cells was performed by immunostaining, reverse transcription-polymerase chain reaction, Western blotting, and biochemical assays.RESULTS:Inflammatory SF cells significantly suppressed the maturation of DCs upon coculture. PG-TCR-Tg mouse T cells cultured with antigen-loaded DCs showed dramatic decreases in proliferation in the presence of SF cells. Spleen myeloid cells from arthritic mice did not have suppressive effects. SF cells were unable to suppress CD3/CD28-stimulated proliferation of the same T cells, suggesting a DC-dependent mechanism. SF cells exhibited all of the characteristics of myeloid-derived suppressor cells (MDSCs) and exerted suppression primarily through the production of nitric oxide and reactive oxygen species by granulocyte-like cells.CONCLUSION:SF in the joints of mice with PGIA contains a population of granulocytic MDSCs that potently suppress DC maturation and T cell proliferation. These MDSCs have the potential to limit the expansion of autoreactive T cells, thus breaking the vicious cycle of autoimmunity and inflammation.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Arthritis and Rheumatism 64 : 10 (2012), p. 3179-3188. -
További szerzők:	Kurkó Júlia Emese (1979-) (reumatológus) Besenyei Tímea (1980-) (reumatológus, belgyógyász) Tryniszewska Beáta Rauch Tibor A. Glant Tibor T. Mikecz Katalin
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001-es BibID:	BIBFORM050381
035-os BibID:	PMID:23653330
Első szerző:	Glant Tibor T.
Cím:	Differentially expressed epigenome modifiers, including aurora kinases A and B, in immune cells in rheumatoid arthritis in humans and mouse models / Tibor T. Glant, Timea Besenyei, András Kádár, Júlia Kurkó, Beata Tryniszewska, János Gál, Györgyi Soós, Zoltán Szekanecz, Gyula Hoffmann, Joel A. Block, Robert S. Katz, Katalin Mikecz, Tibor A. Rauch
Dátum:	2013
ISSN:	0004-3591
Megjegyzések:	To identify epigenetic factors that are implicated in the pathogenesis of rheumatoid arthritis (RA), and to explore the therapeutic potential of the targeted inhibition of these factors. METHODS: Polymerase chain reaction (PCR) arrays were used to investigate the expression profile of genes that encode key epigenetic regulator enzymes. Mononuclear cells from RA patients and mice were monitored for gene expression changes, in association with arthritis development in murine models of RA. Selected genes were further characterized by quantitative reverse transcription-PCR, Western blot, and flow cytometry methods. The targeted inhibition of the up-regulated enzymes was studied in arthritic mice. RESULTS: A set of genes with arthritis-specific expression was identified by the PCR arrays. Aurora kinases A and B, both of which were highly expressed in arthritic mice and treatment-naive RA patients, were selected for detailed analysis. Elevated aurora kinase expression was accompanied by increased phosphorylation of histone H3, which promotes proliferation of T lymphocytes. Treatment with VX-680, a pan-aurora kinase inhibitor, promoted B cell apoptosis, provided significant protection against disease onset, and attenuated inflammatory reactions in arthritic mice. CONCLUSION: Arthritis development is accompanied by changes in expression of a number of epigenome-modifying enzymes. Drug-induced down-regulation of the aurora kinases, among other targets, seems to be sufficient to treat experimental arthritis. Development of new therapeutics that target aurora kinases can potentially improve RA management.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban epigenome modifiers rheumatoid arthritis
Megjelenés:	Arthritis and Rheumatism. - 65 : 7 (2013), p. 1725-1735. -
További szerzők:	Besenyei Tímea (1980-) (reumatológus, belgyógyász) Kádár András (1977-) (belgyógyász) Kurkó Júlia Emese (1979-) (reumatológus) Tryniszewska Beáta Gál János Soós Györgyike (1959-) (pathológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Hoffmann Gyula Block, Joel A. Katz, Robert S. Mikecz Katalin Rauch Tibor A.
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001-es BibID:	BIBFORM093466
Első szerző:	Kurkó Júlia Emese (reumatológus)
Cím:	Myeloid-Derived Suppressor Cells Present in the Synovial Fluid of Mice with Proteoglycan-Induced Arthritis Are Potent Suppressors of Dendritic Cell Maturation and T Cell Proliferation / Julia Kurko, Colt Egelston, Timea Besenyei, Beata Tryniszewska, Tamas Kobezda, Tibor A. Rauch, Tibor T. Glant, Katalin Mikecz
Dátum:	2011
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	Arthritis & Rheumatism. - 63 : Suppl10 (2011), p. S393. -
További szerzők:	Egelston, Colt Besenyei Tímea (1980-) (reumatológus, belgyógyász) Tryniszewska Beáta Kobezda Tamás (1983-) (Ph.D hallgató) Rauch Tibor A. Glant Tibor T. Mikecz Katalin
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