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001-es BibID:	BIBFORM004703
035-os BibID:	(scopus)0037013728 (wos)000176059200014
Első szerző:	Damjanovich Sándor (biofizikus)
Cím:	Does mosaicism of the plasma membrane at molecular and higher hierarchical levels in human lymphocytes carry information on the immediate history of cells? / Damjanovich, S., Matyus, L., Damjanovich, L., Bene, L., Jenei, A., Matko, J., Gaspar, R., Szollosi, J.
Dátum:	2002
Megjegyzések:	A theoretical analysis of experimental data is presented in this mini-review on non-random homo- and hetero-associations of cell surface receptors, which can be recruited in the plasma membrane or at the surface of the rough endoplasmic reticulum during the protein synthesis. In the latter case, the likely genetic origin of these supramolecular formations is analyzed, contrasting this concept to the mobility of the cell surface proteins. A model is offered which, on the one hand, allows the mobility in a restricted way even among microdomain-confined receptor proteins through 'swapping partners'. On the other hand, the lack of mixing molecular components of protein clusters will be analyzed, when homo-and hetero-associations are studied through cell fusion experiments. The most frequently studied cell surface patterns have included lipid raft organized HLA class I and II, ICAM-1, tetraspan molecules, IL2 and IL15 and other receptors, as well. On the contrary coated pit-associated transferrin receptors would not mix with the above lipid raft associated receptor patterns, although transferrin receptor would readily oligomerize into homo-associates. The functional consequences of these superstructures are also analyzed. On the 30th anniversary of the Singer-Nicolson fluid mosaic membrane model one has to pay tribute to the authors, because of their deep insight emphasizing also the mosaicism of the membranes in general and that of the plasma membrane, in particular.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk analysis Biophysics Cell Fusion Cells Human Hungary Lymphocytes Proteins egyetemen (Magyarországon) készült közlemény
Megjelenés:	Immunology Letters. - 82 : 1-2 (2002), p. 93-99. -
További szerzők:	Mátyus László (1956-) (biofizikus) Damjanovich László (1960-) (általános sebész) Bene László (1963-) (biofizikus) Jenei Attila (1966-) (biofizikus) Matkó János (1952-) (biológus) Gáspár Rezső (1944-) (biofizikus) Szöllősi János (1953-) (biofizikus)
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001-es BibID:	BIBFORM005982
Első szerző:	Kotlán B.
Cím:	The different effect of alpha and gamma interferons and interleukin 2 on the expression of CD2, CD3, CD4 and CD8 antigens in comparison to histocompatibility antigens of human lymphocytes / Kotlán, B., Böck, G., Rajnavölgyi, E., Benczur, M., Mátyus, L., Gyódi, E., Huber, C., Petrányi, G. G.
Dátum:	1988
Megjegyzések:	The effects of alpha- and gamma-interferons (IFN-alpha, -gamma) and of interleukin 2 (IL-2) on the expression of certain differentiation antigens were compared with those of major histocompatibility antigens on human lymphocytes. IFN-gamma and IFN-alpha in high doses significantly increased the expression of T11 (CD2) differentiation antigen, but did not affect the expression of T4 (CD4), T8 (CD8), T3 (CD3) and Leu-7 antigens (HNK-1). Both natural and recombinant IFN-alpha and -beta apparently increased the expression of HLA-ABC antigens and of beta-2 microglobulin (beta 2m) after 16 h incubation. The amount of HLA-DR antigen, however, doubled in a few hours following IFN-gamma treatment. IL-2 affected the expression of CD2 and CD8 antigens only marginally, but did not affect that of CD3 and Leu-7; however, it strongly enhanced the expression of HLA-ABC, HLA-DR, and beta 2m antigens.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Antigens,Differentiation Antigens,Differentiation,T-Lymphocyte biosynthesis blood Comparative Study Histocompatibility Antigens HLA Antigens Human Hungary immunology In Vitro Interferon Type I Interferon Type II Interferons Interleukin-2 Lymphocytes pharmacology Receptors,Interleukin-2
Megjelenés:	Immunology Letters. - 18 : 4 (1988), p. 259-268. -
További szerzők:	Böck, G. Rajnavölgyi Éva (1950-) (immunológus) Benczur M. Mátyus László (1956-) (biofizikus) Gyódi E. Huber, C. Petrányi Gyula (1912-2000) (belgyógyász)
Internet cím:	elektronikus változat DOI Intézményi repozitóriumban (DEA) tárolt változa
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001-es BibID:	BIBFORM046280
Első szerző:	Mátyus László (biofizikus)
Cím:	Distinct association of transferrin receptor with HLA class I molecules on HUT-102B and JY cells / Mátyus László, Bene László, Heiligen Harry, Rausch Jeff, Damjanovich Sándor
Dátum:	1995
ISSN:	0165-2478
Megjegyzések:	The topological relationship of transferrin receptor (TfR) has been studied relative to the heavy and light chains of the HLA class I molecules, class II molecules, interleukin-2 receptor alpha-chain and ICAM-1 molecule in the plasma membrane of HUT-102B2 T and JY B lymphoblastoid cell lines using the flow cytometric fluorescence energy transfer technique (FCET). The effect of different growing conditions (logarithmic and plateau phases) on the relative surface density of the receptors and the lateral organization of the TfR was also studied. The TfR showed a high degree of self-association on the surface of both cell lines regardless of the growing phase. TfR was in close vicinity to HLA class I heavy and light chains on HUT-102B cells in both plateau and logarithmic phases, while it was not associated with HLA class I on the surface of JY cells. HLA class II molecules form a cluster with TfR on HUT-102B cells, while only a modest association was found on JY cells, and only in the logarithmic phase. The possible explanation of this distinct association and a two dimensional model of the antigen and receptor distributions are presented in this paper.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Immunology Letters. - 44 : 2-3 (1995), p. 203-208. -
További szerzők:	Bene László (1963-) (biofizikus) Heiligen, Harry Rausch, Jeff Damjanovich Sándor (1936-2017) (biofizikus)
Pályázati támogatás:	1492 OTKA T6221 OTKA T6163 OTKA ETT 469 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM005997
Első szerző:	Surányi Péter
Cím:	Subset specificity of lupus antilymphocyte antibodies studied by two-colour microfluorimetry / Péter Surányi, László Mátyus, Ildikó Sonkoly, Gyula Szegedi
Dátum:	1985
Megjegyzések:	Subset specific lymphocytotoxic activity of lupus sera was studied by a combination of selective immunofluorescence labelling and complement-mediated lysis. Most frequently death of B cells was detected. Many of the sera caused lysis of T lymphocytes; selective cytotoxicity against suppressor T cells could be observed less frequently. All the anti-T4, anti-T8 and anti-B lymphocyte antibodies proved to be cold reactive.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Antibodies Antibody Specificity Antilymphocyte Serum classification Fluorometry Human immunology Lupus Erythematosus,Systemic Lymphocytes Support,Non-U.S.Gov't T-Lymphocytes
Megjelenés:	Immunology Letters. - 10 : 2 (1985), p. 91-93. -
További szerzők:	Mátyus László (1956-) (biofizikus) Sonkoly Ildikó Szegedi Gyula (1936-2013) (belgyógyász, immunológus)
Internet cím:	elektronikus változat DOI Intézményi repozitóriumban (DEA) tárolt változa
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