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001-es BibID:	BIBFORM023404
Első szerző:	Hidasi Eszter (neurológus)
Cím:	No correlation between impairment of cerebrovascular reserve capacity and electrophysiologically assessed severity of neuropathy in noninsulin-dependent diabetes mellitus / Hidasi E., Káplár M., Diószeghy P., Bereczki D., Csiba L., Limburg M., Fülesdi B.
Dátum:	2002
Megjegyzések:	Microvascular abnormalities have an important role in the most frequent neurological complications of diabetes mellitus: neuropathy and cerebrovascular disorders. Severity of neuropathy as well as of cerebral microvascular damage can be quantitatively evaluated by instrumental methods like nerve conduction studies and transcranial Doppler. In the present study, we investigated whether a correlation exists between the severity of peripheral neuropathy and the impairment of cerebrovascular reserve capacity (CRC) in 20 patients with Type 2 diabetes mellitus. METHODS: CRC was measured by transcranial Doppler and defined as the maximal percentage increase in blood flow velocity in the middle cerebral artery within 20 min after an intravenous dose of 1000 mg of acetazolamide. Nerve conduction studies of the median, ulnar, peroneal, and sural nerves were performed. Severity of neuropathy was scored based on conduction velocities, amplitudes, and distal latencies. RESULTS: There was no correlation between the neuropathic score and CRC (R= .003, P= .99). Neither CRC nor the neuropathic score correlated significantly with age, duration of diabetes, and serum values of HbA(1c), glucose, insulin, von Willebrand factor, and alpha(2) - macroglobulin. Severity of neuropathy but not CRC correlated with microalbuminuria (R= .47, P= .038 and R= .14, P= .54). Improper treatment reflected by HbA(1c) >10% was associated with significantly more severe albuminuria, higher actual blood glucose level, higher von Willebrand factor activity, and marginally higher neuropathic score (21 vs. 13, P=.096), but was not associated with CRC (44% vs. 42%, P= .81). When duration of diabetes was dichotomized to 15 years and less or over 15 years, CRC was significantly smaller (35% vs. 50%, P= .036) and neuropathy was more severe in the subgroup with longer diabetes duration (19 vs. 11.5 points, P= .07). CONCLUSIONS: Although both CRC and peripheral nerve function are affected more severely in patients with long-lasting Type 2 diabetes mellitus, damage in the cerebrovascular system and in the long peripheral nerves occur independently. As in diabetes mellitus pathological changes in autonomic and large peripheral nerves develop simultaneously, decreased CRC in diabetic patients might be predominantly due to structural changes of resistance arteries or to metabolic than to neurogenic factors.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Diabetes and its Complications. - 16 : 3 (2002), p. 228-234. -
További szerzők:	Káplár Miklós (1965-) (belgyógyász, diabetológus) Diószeghy Péter (1948-) (ideg- és elmeszakorvos) Bereczki Dániel (1960-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter) Limburg, Martien Fülesdi Béla (1961-) (aneszteziológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM010564
035-os BibID:	WOS:000264742800019
Első szerző:	Hidasi Eszter (neurológus)
Cím:	Peripheral nerves are progressively involved in multiple sclerosis : a hypothesis from a pilot study of temperature sensitized electroneurographic screening / Eszter Hidasi, Péter Diószeghy, Tünde Csépány, Ferenc Mechler, Dániel Bereczki
Dátum:	2009
Megjegyzések:	Multiple sclerosis (MS) is primarily a disease of the central nervous system. Although the involvement of the peripheral nervous system in MS was suggested over 100 years ago, the issue is still controversial, and it is generally accepted that except for the optic nerve the peripheral nerves are left unaffected by the disease. We hypothesize, that an electroneurographical study if thorough enough, may reveal differences in some nerve conduction parameters between MS patients and healthy subjects. Second, we assume that the sensitivity of nerve conduction measurements might be increased if performed at a range of temperatures, reflecting a differential effect of cooling and warming on the peripheral nerve conduction parameters in MS patients and controls. Finally, we expect that the differences in these parameters between controls and MS patients will increase with the progression of the disease. To test these hypotheses in a pilot study, we performed a detailed analysis of the motor and sensory nerve conduction features of the right median nerve in 13 MS patients and 13 controls at 5 C increments between 20 and 40 C, and repeated these measurements after 3 years. The motor latencies were 0.3-0.6 ms longer in MS patients compared to the controls both initially and 3 years later (0.058 < p < 0.09). The durations and areas of the compound motor action potential (CMAP) appeared more sensitive to changes in temperature in the MS group (0.057 < p < 0.1). The change in both distal motor latency and sensory latency per unit change in temperature decreased significantly in 3 years within the MS but not in the control group. These results suggest a mild and progressive involvement of the PNS in MS. Most differences in this pilot study were on the border of statistical significance therefore our hypotheses should be confirmed in studies with larger sample size.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Medical Hypotheses. - 72 : 5 (2009), p. 562-566. -
További szerzők:	Diószeghy Péter (1948-) (ideg- és elmeszakorvos) Csépány Tünde (1956-) (neurológus, pszichiáter) Mechler Ferenc (1933-) (neurológus) Bereczki Dániel (1960-) (neurológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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