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001-es BibID:	BIBFORM061172
Első szerző:	Czuriga-Kovács Katalin Réka (neurológus)
Cím:	Carotid artery : overview on current trials-selecting the low-risk patient. / Katalin Réka Czuriga-Kovács, Martin M. Brown
Dátum:	2015
Megjegyzések:	The ultimate goal of carotid stenosis treatment is the long-term prevention of stroke. While a large number of studies focusing on patients with symptomatic carotid stenosis have been carried out, fewer data are available from trials on asymptomatic and low-risk patients. Currently existing information on the optimal management of these patients is inconclusive and contradictory. Our aim was to review previous major trials conducted on carotid disease with a main focus on asymptomatic patients with carotid stenosis. Efforts to present currently ongoing trials involving asymptomatic carotid patients, to survey recent studies determining patients' risk for future stroke or periprocedural events, as well as to summarize data on promising structural and functional variables and biomarkers predicting future stroke risk have been made.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban asymptomatic carotid stenosis stroke risk optimized medical therapy carotid endarterectomy carotid artery stenting
Megjelenés:	The Journal of Cardiovascular Surgery 56 : 2 (2015), p. 177-188. -
További szerzők:	Brown, Martin M.
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM061171
Első szerző:	Huibers, A.
Cím:	Mechanism of Procedural Stroke Following Carotid Endarterectomy or Carotid Artery Stenting Within the International Carotid Stenting Study (ICSS) Randomised Trial / A. Huibers, D. Calvet, F. Kennedy, K. R. Czuriga-Kovács, R. L. Featherstone, F. L. Moll, M. M. Brown, T. Richards, G. J. de Borst
Dátum:	2015
ISSN:	1078-5884
Megjegyzések:	OBJECTIVE:To decrease the procedural risk of carotid revascularisation it is crucial to understand the mechanisms of procedural stroke. This study analysed the features of procedural strokes associated with carotid artery stenting (CAS) and carotid endarterectomy (CEA) within the International Carotid Stenting Study (ICSS) to identify the underlying pathophysiological mechanism.MATERIALS AND METHODS:Patients with recently symptomatic carotid stenosis (1,713) were randomly allocated to CAS or CEA. Procedural strokes were classified by type (ischaemic or haemorrhagic), time of onset (intraprocedural or after the procedure), side (ipsilateral or contralateral), severity (disabling or non-disabling), and patency of the treated artery. Only patients in whom the allocated treatment was initiated were included. The most likely pathophysiological mechanism was determined using the following classification system: (1) carotid-embolic, (2) haemodynamic, (3) thrombosis or occlusion of the revascularised carotid artery, (4) hyperperfusion, (5) cardio-embolic, (6) multiple, and (7) undetermined.RESULTS:Procedural stroke occurred within 30 days of revascularisation in 85 patients (CAS 58 out of 791 and CEA 27 out of 819). Strokes were predominately ischaemic (77; 56 CAS and 21 CEA), after the procedure (57; 37 CAS and 20 CEA), ipsilateral to the treated artery (77; 52 CAS and 25 CEA), and non-disabling (47; 36 CAS and 11 CEA). Mechanisms of stroke were carotid-embolic (14; 10 CAS and 4 CEA), haemodynamic (20; 15 CAS and 5 CEA), thrombosis or occlusion of the carotid artery (15; 11 CAS and 4 CEA), hyperperfusion (9; 3 CAS and 6 CEA), cardio-embolic (5; 2 CAS and 3 CEA) and multiple causes (3; 3 CAS). In 19 patients (14 CAS and 5 CEA) the cause of stroke remained undetermined.CONCLUSION:Although the mechanism of procedural stroke in both CAS and CEA is diverse, haemodynamic disturbance is an important mechanism. Careful attention to blood pressure control could lower the incidence of procedural stroke.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Carotid artery stenting Carotid endarterectomy Carotid stenosis Procedural stroke Stroke mechanism
Megjelenés:	European Journal Of Vascular And Endovascular Surgery 50 : 3 (2015), p. 281-288. -
További szerzők:	Calvet, D. Kennedy, F. Czuriga-Kovács Katalin Réka (1981-) (neurológus) Featherstone, R. L. Moll, Frans Brown, Martin M. Richards, T. de Borst, G. J.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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