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001-es BibID:	BIBFORM029902
Első szerző:	Hegedűs Katalin (ideggyógyász, neuropathológus)
Cím:	Effect of i.v. dipyridamole on cerebral blood flow, blood pressure, plasma adenosine and cAMP levels in rabbits / Katalin Hegedűs, Tamás Keresztes, István Fekete, László Molnár
Dátum:	1997
ISSN:	0022-510X
Megjegyzések:	In response to intravenous administration of dipyridamole, the quantitative and temporal changes in plasma adenosine and cyclic AMP (cAMP) levels in relation to the changes in cerebral blood flow (CBF) and mean arterial blood pressure (MABP) have not been studied. Therefore, we investigated simultaneously the changes in CBF (hydrogen and thermal clearance methods), MABP, plasma adenosine (HPLC) and cAMP (radioimmunoassay) levels for 1 h after intravenous injection of 0.7 and 1.4 mg/kg dipyridamole in rabbits. In separate experiments, only plasma adenosine concentrations were measured to determine how and for how long intravenous administration of 0.7 mg/kg dipyridamole is able to inhibit the removal of plasma adenosine. Dipyridamole decreased MABP, increased plasma adenosine and cAMP levels in a dose-dependent manner. The dose-dependency of increases in CBF could not be demonstrated owing to the marked hypotension. The increase in plasma adenosine concentrations was biphasic. The first peak could be detected at the end of the dipyridamole injection. The second peak occurred 20 min after drug administration, simultaneously with the maximal increases in plasma cAMP level and CBF, whereas the maximal fall in MABP developed earlier. Intravenous administration of 0.7 mg/kg dipyridamole inhibited adenosine uptake only by 25%, which lasted less than 10 min. We concluded that intravenously given dipyridamole is responsible only for the initial short-lasting elevation of plasma adenosine concentration, and is able to induce vasodilation without either dipyridamole itself or adenosine necessarily gaining access to the muscular layer.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Journal of The Neurological Sciences. - 148 : 2 (1997), p. 153-161. -
További szerzők:	Keresztes Tamás Molnár László (1923-1999) (neurológus) Fekete István (1951-) (neurológus, pszichiáter)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM067788
Első szerző:	Horváth László (gyógyszerész)
Cím:	Outcome of antiepileptic drug treatment of 1282 patients with epilepsy, their pharmacovigilance reports and concomitant medication on CNS in an East-Hungarian adult database / Horváth László, Fekete Klára, Márton Sándor, Fekete István
Dátum:	2016
ISSN:	0022-510X
Megjegyzések:	Objective: The aim of this study was to determine the outcome of antiepileptic drug (AED) treatment based on seizure freedom, pharmacovigilance reports and effects of concomitant medication on the central nervous system (CNS) of adult epileptic patients registered in the East-Hungarian Epilepsy Database.Methods: Prospective cross-sectional database was compiled from outpatient files between 1992 and 2011.Results: The majority of 1282 treated patients were on monotherapy 894 patients (70%), 286 (22%) on bitherapy and 102 (8%) on polytherapy. Of all treated patients, seizure freedom was achieved by 603 (47%). Among the seizure free patients 464 (77%) were on monotherapy, 115 (19%) on bitherapy and only 24 (4%) on polytherapy. The overall rate of adverse drug reactions (ADRs) was 16.2%. From patients on AED, 279 (22%) took concomitant drugs acting on the CNS. In a logistic regression model, other CNS-related drugs and a number of prescribed antiepileptic drugs had a significant influence on the desired outcome of seizure freedom. On comparing the Proportional Reporting Ratio and 95%CI of older and newer AEDs, no significant superiority of newer AEDs was detected.Conclusion: Careful drug selection for epileptic patients must be highlighted in order to improve outcome, reduce ADRs and improve patient compliance.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban epilepsy database antiepileptic drug treatment seizure freedom adverse drug reaction pharmacovigilance
Megjelenés:	Journal of the Neurological Sciences 369 (2016), p. 220-226. -
További szerzők:	Fekete Klára (1978-) (neurológus) Márton Sándor (1965-) (matematikus) Fekete István (1951-) (neurológus, pszichiáter)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM029946
Első szerző:	Szatmári Szabolcs (neurológus)
Cím:	Subcortical features and cognitive performance in Hungarian cerebrovascular outpatients / Szatmári Szabolcs, Csiba László, Fekete István, Bereczki Dániel
Dátum:	2002
ISSN:	0022-510X
Megjegyzések:	Cerebrovascular diseases are common in Central and East Europe, and the resulting cognitive impairment is probably also frequent. Although this problem attracted a lot of attention in the last decade, systematic examination of cognitive functions is not routinely performed in cerebrovascular patients. In our study involving cerebrovascular outpatients, we used the MMSE and the Barthel Index combined with a checklist for the evaluation of subcortical features. From a total of 176 cases, 32% had at least one subcortical sign. Except for gait disturbance and unprovoked falls, patients with subcortical dysfunction had lower performances on MMSE and lower Barthel scores. Their mean age did not differ significantly from the age of patients without subcortical signs, except for the subgroups with urinary and gait disturbances. Cognitive deficit could be detected in 27 patients, nine of them fulfilled the criteria for dementia. Subcortical signs and cognitive impairment can also be present in apparently well-being cerebrovascular patients. The routine evaluation of these deficiencies must be an integral part of the management of cerebrovascular patients and in planning their complex rehabilitation. Short, widely usable and easily executable tests are recommended.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of The Neurological Sciences. - 203-204 (2002), p. 99-101. -
További szerzők:	Csiba László (1952-) (neurológus, pszichiáter) Fekete István (1951-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM019210
Első szerző:	Szilágyi Géza
Cím:	Effects of vinpocetine on the redistribution of cerebral blood flow and glucose metabolism in chronic ischemic stroke patients : a PET study / Szilágyi G., Nagy Z., Balkay L., Boros I., Emri M., Lehel S., Márián T., Molnár T., Szakáll S., Trón L., Bereczki D., Csiba L., Fekete I., Kerényi L., Galuska L., Varga J., Bönöczk P., Vas A., Gulyás B.
Dátum:	2005
ISSN:	0022-510X
Megjegyzések:	The pharmacological effects of the neuroprotective drug vinpocetine, administered intravenously in a 14-day long treatment regime, on the cerebral blood flow and cerebral glucose metabolism in chronic ischemic stroke patients (n=13) were studied with positron emission tomography in a double-blind design. The regional and global cerebral metabolic rates of glucose (CMRglc) and cerebral blood flow (CBF) as well as vital physiological parameters, clinical performance scales, and transcranial Doppler parameters were measured before and after the treatment period in patient groups treated with daily intravenous infusion with or without vinpocetine. While the global CMRglc values did not change markedly as a result of the infusion treatment with (n=6) or without (n=7) vinpocetine, the global CBF increased and regional CMRglc and CBF values showed marked changes in several brain structures in both cases, with more accentuated changes when the infusion contained vinpocetine. In the latter case the highest rCBF changes were observed in those structures in which the highest regional uptake of labelled vinpocetine was measured in other PET studies (thalamus and caudate nucleus: increases amounting to 36% and 37%, respectively). The findings indicate that a 2-week long intravenous vinpocetine treatment can contribute effectively to the redistribution of rCBF in chronic ischemic stroke patients. The effects are most pronounced in those brain regions with the highest uptake of the drug.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Journal Of The Neurological Sciences. - 229-230 (2005), p. 275-284. -
További szerzők:	Nagy Zoltán Balkay László (1963-) (biofizikus) Boros István Emri Miklós (1962-) (fizikus) Lehel Szabolcs Márián Teréz (1950-) (radiobiológus) Molnár Tamás (orvos) Szakáll Szabolcs Trón Lajos (1941-) (biofizikus) Bereczki Dániel (1960-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter) Fekete István (1951-) (neurológus, pszichiáter) Kerényi Levente Galuska László (1946-) (belgyógyász, izotópdiagnoszta) Varga József (1955-) (fizikus) Bönöczk Péter Vas Ádám Gulyás Balázs
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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