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1.

001-es BibID:BIBFORM103370
035-os BibID:(Wos)000491345500001 (Scopus)85064527207 (Pubmed)30957461
Első szerző:Csécsei Péter (neurológus)
Cím:L-arginine pathway metabolites can discriminate paroxysmal from permanent atrial fibrillation in acute ischemic stroke / Csecsei Péter, Várnai Réka, Nagy Lajos, Kéki Sándor, Molnár Tihamér, Illés Zsolt, Farkas Nelli, Szapáry László
Dátum:2019
ISSN:0019-1442
Megjegyzések:Background ? Atrial fibrillation (AF) is the most common arrhythmia diagnosed in clinical practice. We aimed to measure the L-arginine pathway metabolites as well as their ratios in patients with different types of AF or sinus rhythm and to explore the relationship among the markers and clinical variables in the subacute phase of acute ischemic stroke (AIS). Methods ? A total of 46 patients with AIS were prospectively enrolled. The patients were divided into three groups based on diagnosis of either sinus rhythm, paroxysmal or permanent AF. Plasma concentration of the L-arginine pathway metabolites were analyzed at post-stroke 24 hours in the three rhythm groups. Besides, clinical variables and laboratory data were recorded. Results ? Asymmetric dimetylarginine (ADMA) was significantly higher in patients with permanent AF compared to sinus rhythm (p<0.001). Both ADMA (p<0.001) and symmetric dimethylarginine (SDMA) (p<0.002) at 24 hours were significantly higher among patients with permanent AF compared to those with paroxysmal AF. The L-arginine/SDMA (p<0.031) ratios at 24 hours were significantly higher among patients with sinus rhythm compared to those with permanent AF. ROC analysis also revealed that plasma SDMA cut-off level over 0.639 ?mol/L discriminated permanent AF from paroxysmal AF or sinus rhythm with a 90.9% sensitivity and 77.1% specificity. Neutrophil-lymphocyte ratio also showed significantly higher value in individuals with both paroxysmal and permanent AF (p=0.029). Conclusions ? Plasma level of SDMA could discriminate permanent from paroxysmal AF in the subacute phase of ischemic stroke. In addition, an increased neutrophil-lymphocyte ratio may suggest inflammatory process in the evolution of atrial fibrillation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
L-arginine
atrial fibrillation
ischemic stroke
Megjelenés:Ideggyógyászati Szemle. - 72 : 3-4 (2019), p. 79-88. -
További szerzők:Várnai Réka Nagy Lajos (1979-) (vegyész) Kéki Sándor (1964-) (polimer kémikus) Molnár Tihamér (1992-) (általános orvos) Illés Zsolt (neurológus, Pécs) Farkas Nelli Szapáry László (1962-) (általános orvos)
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2.

001-es BibID:BIBFORM106876
035-os BibID:(Wos)000657336100001 (Scopus)85107058660
Első szerző:Csiszár Beáta
Cím:L-Arginine, asymmetric and symmetric dimethylarginine for early outcome prediction in unselected cardiac arrest victims: a prospective cohort study / Beata Csiszar, Zsolt Marton, Janos Riba, Peter Csecsei, Lajos Nagy, Kalman Toth, Robert Halmosi, Barbara Sandor, Peter Kenyeres, Tihamer Molnar
Dátum:2021
ISSN:1828-0447 1970-9366
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Cardiopulmonary resuscitation
Post-resuscitation care
Asymmetric dimethylarginine
Prognostication
Cardiac arrest
Mortality
Megjelenés:Internal and Emergency Medicine. - 17 : 2 (2021), p. 525-534. -
További szerzők:Márton Zsolt Riba János Csécsei Péter (1992-) (neurológus) Nagy Lajos (1979-) (vegyész) Tóth Kálmán Halmosi Róbert Sándor Barbara Kenyeres Péter Molnár Tihamér (1992-) (általános orvos)
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3.

001-es BibID:BIBFORM106888
035-os BibID:(Wos)000735156400001 (Scopus)85119592396 (cikkazonosító)5479
Első szerző:Kovács-Ábrahám Zoltán
Cím:Cerebral and Systemic Stress Parameters in Correlation with Jugulo-Arterial CO2 Gap as a Marker of Cerebral Perfusion during Carotid Endarterectomy / Zoltán Kovács-Ábrahám, Timea Aczél, Gábor Jancsó, Zoltán Horváth-Szalai, Lajos Nagy, Ildikó Tóth, Bálint Nagy, Tihamér Molnár, Péter Szabó
Dátum:2021
ISSN:2077-0383
Megjegyzések:Intraoperative stress is common to patients undergoing carotid endarterectomy (CEA); thus, impaired oxygen and metabolic balance may appear. In this study, we aimed to identify new markers of intraoperative cerebral ischemia, with predictive value on postoperative complications during CEA, performed in regional anesthesia. A total of 54 patients with significant carotid stenosis were recruited and submitted to CEA. Jugular and arterial blood samples were taken four times during operation, to measure the jugulo-arterial carbon dioxide partial pressure difference (P(j-a)CO2), and cortisol, S100B, L-arginine, and lactate levels. A positive correlation was found between preoperative cortisol levels and all S100B concentrations. In addition, they are positively correlated with P(j-a)CO2 values. Conversely, postoperative cortisol inversely correlates with P(j-a)CO2 and postoperative S100B values. A negative correlation was observed between maximum systolic and pulse pressures and P(j-a)CO2 after carotid clamp and before the release of clamp. Our data suggest that preoperative cortisol, S100B, L-arginine reflect patients' frailty, while these parameters postoperatively are influenced by intraoperative stress and injury. As a novelty, P(j-a)CO2 might be an emerging indicator of cerebral blood flow during CEA.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
carotid endarterectomy
carbon dioxide gap
cerebrovascular circulation
cortisol
L-arginine
S100B
frailty
cervical plexus block
Megjelenés:Journal of Clinical Medicine. - 10 : 23 (2021), p. 5479. -
További szerzők:Aczél Timea Jancsó Gábor Horváth-Szalai Zoltán Nagy Lajos (1979-) (vegyész) Tóth Ildikó Nagy Bálint Molnár Tihamér (1992-) (általános orvos) Szabó Péter
Pályázati támogatás:NCT03957018
Egyéb
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4.

001-es BibID:BIBFORM103943
035-os BibID:(cikkazonosító)0300060520920439 (WOS)000541846600001 (Scopus)85086327021
Első szerző:Maros-Szabó Zsuzsanna
Cím:Increased symmetric dimethylarginine, but not asymmetric dimethylarginine, concentrations are associated with transient myocardial ischemia and predict outcome / Zsuzsanna Szabo, Eva Bartha, Lajos Nagy, Tihamer Molnar
Dátum:2020
ISSN:0300-0605 1473-2300
Megjegyzések:Objective Asymmetric and symmetric dimethylarginines (ADMA and SDMA) are endothelial dysfunction markers. ADMA inhibits synthesis of nitric oxide. We aimed to analyze both markers in patients with coronary artery disease (CAD) who were referred for stress/rest myocardial perfusion scintigraphy (MPS). Methods All patients underwent a 2-day dipyridamole (DP) stress/rest protocol. Thereafter, patients with transient myocardial perfusion abnormality were followed up and their coronary blood flow was quantitatively assessed. Venous blood was taken before and after DP stress to measure markers. Results Baseline ADMA and SDMA concentrations were significantly higher in patients with CAD compared with healthy subjects. Pre- and post-stress SDMA concentrations were significantly higher in patients with transient myocardial perfusion abnormality compared with those with negative MPS results. However, ADMA and L-arginine concentrations were not significantly different between the two groups. None of the markers were significantly different between patients with angiographically proven low coronary flow and those with normal coronary flow. Pre-stress SDMA concentrations were an independent predictor of cardiovascular mortality during a 8-year follow-up. Conclusions Elevated serum SDMA concentrations may be helpful for selecting high-risk patients with CAD if there is any doubt in interpreting MPS. SDMA concentrations may also predict cardiovascular outcome.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Dipyridamole
coronary artery disease
asymmetric dimethylarginine
myocardial perfusion scin-tigraphy
L-arginine
cardiovascular mortality
Megjelenés:Journal of International Medical Research. - 48 : 6 (2020), p. 1-9. -
További szerzők:Bartha Éva (radiológus) Nagy Lajos (1979-) (vegyész) Molnár Tihamér (1992-) (általános orvos)
Pályázati támogatás:EFOP-3.6.3-VEKOP-16-2017-00009
EFOP
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM103962
035-os BibID:(cikkazonosító)104951 (WOS)000561808800074 (Scopus)85085647649
Első szerző:Molnár Tihamér (általános orvos)
Cím:Associations between serum L-arginine and ficolins in the early phase of acute ischemic stroke? A pilot study / Tihamer Molnar, Dorottya Csuka,Gabriella Pusch, Lajos Nagy, Peter Garred, Zsolt Illes
Dátum:2020
ISSN:1052-3057 1532-8511
Megjegyzések:Introduction: Activation of both the L-arginine and the lectin pathway contributes to the pathophysiology and the outcome of acute ischemic stroke (AIS). However, the interplay between the two systems has not yet been examined. Methods: A total of 44 patients with AIS were recruited into this study. Serial measurement of serum L-arginine, asymmetric and symmetric dimethylarginine (ADMA, SDMA), and hsCRP, ficolin-2, ficolin-3, MAP-1, MASP-3 and mannose-binding lectin (MBL) were analyzed within 6 h after onset of stroke and 72 h later. Outcomes were assessed as National Institutes of Health Stroke Scale (NIHSS) worsening by 24 h, poststroke infection, and death by 1 month. Results: In the hyperacute stage of AIS, ficolin-3, MAP-1 and MBL were positively correlated with L-arginine within 6 h after onset of symptoms (p<0.05 respectively). Significantly lower ficolin-3 and MASP-3 levels were found at 72 h in patients, who developed post-stroke infection after day 4, when compared to patients without post-stroke infections (p=0.03 and p=0.009). At 72 hours, ficolin-3 levels negatively correlated with S100B (p=0.01). Ficolin-3 at 72 post-stroke hours remained an independent predictor of post-stroke infection, while only hsCRP was an independent predictor of 30-day mortality. Conclusion: Early consumption of ficolin-3 is associated with complications such as post-stroke infections. In the hyperacute phase of AIS, the positive correlation between ficolins and the NO donor L-arginine may reflect the protective role of L-arginine presumably by improving the cerebral microcirculation in a prothrom-botic environment induced by complement activation.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Ischemic stroke
L-arginine
Ficolin
Mannose- binding lectin
Infection
Outcome
Megjelenés:Journal of Stroke and Cerebrovascular Diseases. - 29 : 8 (2020), p. 1-7. -
További szerzők:Csuka Dorottya Pusch Gabriella Nagy Lajos (1979-) (vegyész) Garred, Peter Illés Zsolt
Pályázati támogatás:EFOP-3.6.3-VEKOP-16-2017-000
Egyéb
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6.

001-es BibID:BIBFORM092482
Első szerző:Molnár Tihamér (általános orvos)
Cím:Methylarginine derivatives as early markers of endothelial dysfunction in asymptomatic carotid stenosis and acute ischemic stroke / T. Molnar, L. Nagy, S. Keki, G. Pusch, Z. Illes
Dátum:2011
ISSN:1351-5101
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal of Neurology. - 11 : Suppl. 2 (2011), p. 400-400. -
További szerzők:Nagy Lajos (1979-) (vegyész) Kéki Sándor (1964-) (polimer kémikus) Pusch Gabriella Illés Zsolt (neurológus, Pécs)
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Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:BIBFORM085257
Első szerző:Molnár Tihamér (általános orvos)
Cím:The L-arginine Pathway in Acute Ischemic Stroke and Severe Carotid Stenosis: Temporal Profiles and Association with Biomarkers and Outcome / Molnár Tihamér, Pusch Gabriella, Papp Viktória, Fehér Gergely, Szapáry László, Biri Bernadett, Nagy Lajos, Kéki Sándor, Illés Zsolt
Dátum:2014
ISSN:1052-3057 1532-8511
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Stroke and Cerebrovascular Diseases. - 23 : 8 (2014), p. 2206-2214. -
További szerzők:Pusch Gabriella Papp Viktória Fehér Gergely Szapáry László (1962-) (általános orvos) Biri Bernadett (1986-) (vegyész) Nagy Lajos (1979-) (vegyész) Kéki Sándor (1964-) (polimer kémikus) Illés Zsolt
Pályázati támogatás:K 77892
OTKA
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8.

001-es BibID:BIBFORM081479
Első szerző:Ruzsics István
Cím:L-Arginine Pathway in COPD Patients with Acute Exacerbation : A New Potential Biomarker / István Ruzsics, Lajos Nagy, Sándor Kéki, Veronika Sárosi, Balázs Illés, Zsolt Illés, Ildikó Horváth, Lajos Bogár, Tihamér Molnár
Dátum:2016
ISSN:1541-2555 1541-2563
Megjegyzések:Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains a major cause of mortality. Clinical criteria of AECOPD are subjective. Biomarkers for AECOPD may aid in the initiation of early treatment. Increased production of asymmetric and symmetric dimethylarginine (ADMA, SDMA) is related to hypoxia. In COPD, a rise in ADMA results in a shift of L-arginine breakdown, contributing to airway obstruction. We aimed to compare serum levels of ADMA, SDMA and L-arginine in patients with and without AECOPD. Methods: L-arginine metabolites quantifi ed by high-performance liquid chromatography in venous blood samples and partial capillary oxygen pressure were prospectively investigated in 32 patients with COPD, 12 with AECOPD and 30 healthy subjects. Results: Both ADMA and SDMA were signifi cantly higher in AECOPD compared to stable COPD (p = 0.004 and p < 0.001, respectively). Oxygen content in capillaries correlated with serum ADMA concentration. However, the concentration of L-arginine was not different between AECOPD and stable COPD. Both ADMA and SDMA separated AECOPD with high sensitivity and specifi city (AUC: 0.81, p = 0.001; AUC: 0.91, p < 0.001, respectively). A cut-off value ?0.57 for SDMA was an independent variable to confi rm AECOPD in a regression model (OR: 1.632, p = 0.001). All markers were signifi cantly higher in the sera of both patient groups compared to the controls (p < 0.05, respectively). Conclusions: COPD is associated with elevated L-arginine, ADMA and SDMA serum levels. In patients with AECOPD, production of ADMA and SDMA are more pronounced presumably due to more severe hypoxic insult. Methylated arginine derivatives in the sera may help early recognition of AECOPD.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
asymmetric and symmetric dimethylarginine
chronic obstructive pulmonary disease
L-arginine
Megjelenés:COPD Journal of Chronic Obstructive Pulmonary Disease. - 13 : 2 (2016), p. 139-145. -
További szerzők:Nagy Lajos (1979-) (vegyész) Kéki Sándor (1964-) (polimer kémikus) Sárosi Veronika Illés Miklós Balázs Illés Zsolt (neurológus, Pécs) Horváth Ildikó (1964-) (tüdőgyógyász) Bogár Lajos Molnár Tihamér (1992-) (általános orvos)
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9.

001-es BibID:BIBFORM113372
035-os BibID:(cikkazonosító)371 (Scopus)85148855445 (WoS)000940472600001
Első szerző:Závori László
Cím:Cystatin-c May Indicate Subclinical Renal Involvement, While Orosomucoid Is Associated with Fatigue in Patients with Long-COVID Syndrome / Laszlo Zavori, Tihamer Molnar, Reka Varnai, Andrea Kanizsai, Lajos Nagy, Bence Vadkerti, Balazs Szirmay, Attila Schwarcz, Peter Csecsei
Dátum:2023
ISSN:2075-4426
Megjegyzések:Long-COVID syndrome is associated with high healthcare costs, but its pathophysiology is not yet fully understood. Inflammation, renal impairment or disturbance of the NO system emerge as potential pathogenetic factors. We aimed to investigate the relationship between symptoms of long-COVID syndrome and serum levels of cystatin-c (CYSC), orosomucoid (ORM), l-arginine, symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA). A total of 114 patients suffering from long-COVID syndrome were included in this observational cohort study. We found that serum CYSC was independently associated with the anti-spike immunoglobulin (S-Ig) serum level (OR: 5.377, 95% CI: 1.822-12.361; p = 0.02), while serum ORM (OR: 9.670 (95% CI: 1.34-9.93; p = 0.025) independently predicted fatigue in patients with long-COVID syndrome, both measured at baseline visit. Additionally, the serum CYSC concentrations measured at the baseline visit showed a positive correlation with the serum SDMA levels. The severity of abdominal and muscle pain indicated by patients at the baseline visit showed a negative correlation with the serum level of L-arginine. In summary, serum CYSC may indicate subclinical renal impairment, while serum ORM is associated with fatigue in long-COVID syndrome. The potential role of l-arginine in alleviating pain requires further studies.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Personalized Medicine. - 13 : 2 (2023), p. 1-8. -
További szerzők:Molnár Tihamér (1992-) (általános orvos) Várnai Réka Kanizsai Andrea Nagy Lajos (1979-) (vegyész) Vadkerti Bence (1994-) (okleveles vegyészmérnök) Szirmay Balázs Schwarcz Attila Csécsei Péter (1992-) (neurológus)
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