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001-es BibID:	BIBFORM103370
035-os BibID:	(Wos)000491345500001 (Scopus)85064527207 (Pubmed)30957461
Első szerző:	Csécsei Péter (neurológus)
Cím:	L-arginine pathway metabolites can discriminate paroxysmal from permanent atrial fibrillation in acute ischemic stroke / Csecsei Péter, Várnai Réka, Nagy Lajos, Kéki Sándor, Molnár Tihamér, Illés Zsolt, Farkas Nelli, Szapáry László
Dátum:	2019
ISSN:	0019-1442
Megjegyzések:	Background ? Atrial fibrillation (AF) is the most common arrhythmia diagnosed in clinical practice. We aimed to measure the L-arginine pathway metabolites as well as their ratios in patients with different types of AF or sinus rhythm and to explore the relationship among the markers and clinical variables in the subacute phase of acute ischemic stroke (AIS). Methods ? A total of 46 patients with AIS were prospectively enrolled. The patients were divided into three groups based on diagnosis of either sinus rhythm, paroxysmal or permanent AF. Plasma concentration of the L-arginine pathway metabolites were analyzed at post-stroke 24 hours in the three rhythm groups. Besides, clinical variables and laboratory data were recorded. Results ? Asymmetric dimetylarginine (ADMA) was significantly higher in patients with permanent AF compared to sinus rhythm (p<0.001). Both ADMA (p<0.001) and symmetric dimethylarginine (SDMA) (p<0.002) at 24 hours were significantly higher among patients with permanent AF compared to those with paroxysmal AF. The L-arginine/SDMA (p<0.031) ratios at 24 hours were significantly higher among patients with sinus rhythm compared to those with permanent AF. ROC analysis also revealed that plasma SDMA cut-off level over 0.639 ?mol/L discriminated permanent AF from paroxysmal AF or sinus rhythm with a 90.9% sensitivity and 77.1% specificity. Neutrophil-lymphocyte ratio also showed significantly higher value in individuals with both paroxysmal and permanent AF (p=0.029). Conclusions ? Plasma level of SDMA could discriminate permanent from paroxysmal AF in the subacute phase of ischemic stroke. In addition, an increased neutrophil-lymphocyte ratio may suggest inflammatory process in the evolution of atrial fibrillation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban folyóiratcikk L-arginine atrial fibrillation ischemic stroke
Megjelenés:	Ideggyógyászati Szemle. - 72 : 3-4 (2019), p. 79-88. -
További szerzők:	Várnai Réka Nagy Lajos (1979-) (vegyész) Kéki Sándor (1964-) (polimer kémikus) Molnár Tihamér (1992-) (általános orvos) Illés Zsolt (neurológus, Pécs) Farkas Nelli Szapáry László (1962-) (általános orvos)
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001-es BibID:	BIBFORM113372
035-os BibID:	(cikkazonosító)371 (Scopus)85148855445 (WoS)000940472600001
Első szerző:	Závori László
Cím:	Cystatin-c May Indicate Subclinical Renal Involvement, While Orosomucoid Is Associated with Fatigue in Patients with Long-COVID Syndrome / Laszlo Zavori, Tihamer Molnar, Reka Varnai, Andrea Kanizsai, Lajos Nagy, Bence Vadkerti, Balazs Szirmay, Attila Schwarcz, Peter Csecsei
Dátum:	2023
ISSN:	2075-4426
Megjegyzések:	Long-COVID syndrome is associated with high healthcare costs, but its pathophysiology is not yet fully understood. Inflammation, renal impairment or disturbance of the NO system emerge as potential pathogenetic factors. We aimed to investigate the relationship between symptoms of long-COVID syndrome and serum levels of cystatin-c (CYSC), orosomucoid (ORM), l-arginine, symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA). A total of 114 patients suffering from long-COVID syndrome were included in this observational cohort study. We found that serum CYSC was independently associated with the anti-spike immunoglobulin (S-Ig) serum level (OR: 5.377, 95% CI: 1.822-12.361; p = 0.02), while serum ORM (OR: 9.670 (95% CI: 1.34-9.93; p = 0.025) independently predicted fatigue in patients with long-COVID syndrome, both measured at baseline visit. Additionally, the serum CYSC concentrations measured at the baseline visit showed a positive correlation with the serum SDMA levels. The severity of abdominal and muscle pain indicated by patients at the baseline visit showed a negative correlation with the serum level of L-arginine. In summary, serum CYSC may indicate subclinical renal impairment, while serum ORM is associated with fatigue in long-COVID syndrome. The potential role of l-arginine in alleviating pain requires further studies.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of Personalized Medicine. - 13 : 2 (2023), p. 1-8. -
További szerzők:	Molnár Tihamér (1992-) (általános orvos) Várnai Réka Kanizsai Andrea Nagy Lajos (1979-) (vegyész) Vadkerti Bence (1994-) (okleveles vegyészmérnök) Szirmay Balázs Schwarcz Attila Csécsei Péter (1992-) (neurológus)
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