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001-es BibID:	BIBFORM106923
035-os BibID:	(Wos)000734253500001 (Scopus)85121990266
Első szerző:	Cukierman, Daphne Schneider
Cím:	Full Equilibrium Picture in Aqueous Binary and Ternary Systems Involving Copper(II), 1-Methylimidazole-Containing Hydrazonic Ligands, and the 103-112 Human Prion Protein Fragment / Daphne S. Cukierman, Nikolett Bodnár, Renata Diniz, Lajos Nagy, Csilla Kállay, Nicolás A. Rey
Dátum:	2021
ISSN:	0020-1669 1520-510X
Megjegyzések:	In this work, we describe two novel 1-methylimidazole N-acylhydyrazonic ligands and their interaction with copper(II) in solution. Binary systems constituted by each of these hydrazones and the metal ion were studied by potentiometric titrations. The magnitude of their affinities for zinc(II) was also determined for the sake of comparison. Additionally, a full evaluation of the copper(II) chelation profile of the new ligands in ternary systems containing a human prion protein fragment was performed. Mixed ligand complexes comprising the HuPrP103?112 fragment, copper(II) ions, and an N-acylhydrazone were characterized by potentiometry, ultraviolet?visible spectroscopy, and circular dichroism. Some of these species were also identified by electrospray ionization mass spectrometry and unequivocally assigned through their isotopic distribution pattern. To the best of our knowledge, this is the first report concerning the stability of ternary complexes involving a hydrazonic metal?protein interaction modulator, copper, and a peptide. The ability of N-acylhydrazones to prevent peptide oxidation was also examined. Both ligands can partially prevent the formation of the doubly oxidized product, a process mediated by copper(II) ions. Oxidative stress is considered an important hallmark of neurodegenerative diseases such as prion-related spongiform encephalopathies. In this context, active intervention with respect to the deleterious copper-catalyzed methionine oxidation could represent an interesting therapeutic approach.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény hazai lapban folyóiratcikk
Megjelenés:	Inorganic Chemistry. - 61 : 1 (2021), p. 723-737. -
További szerzők:	Bodnár Nikolett (1994-) (vegyész) Diniz, Renata Nagy Lajos (1979-) (vegyész) Kállay Csilla (1978-) (vegyész) Rey, Nicolas Adrian
Pályázati támogatás:	NKFI-115480 OTKA NKFI-128783 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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