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001-es BibID:	BIBFORM041173
Első szerző:	Burch, Henry B.
Cím:	Nucleotide and amino acid homology between the human thyrotropin receptor and the HIV-1 nef protein: Identification and functional analysis / Burch Henry B., Nagy Endre V., Lukes Yvonne G., Wartofsky Leonard, Burman Kenneth D.
Dátum:	1991
ISSN:	0006-291X
Megjegyzések:	A comparison of the nucleotide sequence of the human thyrotropin receptor (hTSH-R) with that of HIV-1 revealed 61% homology between a 161 base pair region encoding a unique portion of the hTSH-R and an immunogenic HIV-1 regulatory protein, nef. Amino acid analysis of this region shows 27% homology, including a segment in which 7/10 consecutive amino acids are identical. Sera from rabbits successfully immunized with a 16 amino acid portion of the hTSH-R (352-367, p1) was assessed for reactivity against a partially homologous nef peptide (nef-1) by ELISA, with a finding five-fold higher post-immunization values compared to pre-immune sera. The specificity of this response was verified with Western blot, using recombinant nef protein. An ELISA using nef-1 gave 64% higher values with sera from Graves' disease patients than with normal controls. This homology and immunologic cross-reactivity suggests an avenue through which a shared immune response against an HIV-1 related retrovirus could play a role in the pathogenesis of Graves' disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Biochemical And Biophysical Research Communications. - 181 : 1 (1991), p. 498-505. -
További szerzők:	Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Lukes, Yvonne G. Wartofsky, Leonard Burman, Kenneth D.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM041174
Első szerző:	Nagy Endre V. (belgyógyász, endokrinológus)
Cím:	Graves' IgG recognizes linear epitopes in the human thyrotropin receptor / Nagy Endre V., Burch Henry B., Mahoney Karen, Lukes Yvonne G., Morris John C., Burman Kenneth D.
Dátum:	1992
ISSN:	0006-291X
Megjegyzések:	Twenty-nine peptides covering the full extracellular domain of the human thyrotropin receptor have been synthesized and tested for reactivity with Graves' patients' and normal sera in ELISA. Two peptides, amino acids 331-350 and the second extracellular loop of the transmembrane segment, bound IgG-s from 5 and 4 of 10 Graves' disease patients' sera, respectively. Neither of these two peptides showed enhanced binding to normal IgG. There were no apparent differences between the Graves' disease and normal group with respect to the other 27 peptides. We conclude that peptide 331-350 and the second extracellular loop carry important linear epitopes which may contribute to the disease process in selected Graves' patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Biochemical And Biophysical Research Communications. - 188 : 1 (1992), p. 28-33. -
További szerzők:	Burch, Henry B. Mahoney, Karen Lukes, Yvonne G. Morris, John C. Burman, Kenneth D.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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