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001-es BibID:BIBFORM041191
Első szerző:Mezősi Emese
Cím:Prevalence of iodine deficiency and goitre during pregnancy in east Hungary / Mezosi E., Molnar I., Jakab A., Balogh E., Karanyi Z., Pakozdy Z., Nagy P., Gyory F., Szabo J., Bajnok L., Leovey A., Kakuk G., Nagy E. V.
Dátum:2000
ISSN:0804-4643
Megjegyzések:OBJECTIVE: To assess the iodine nutritional status and the prevalence of goitre during pregnancy in a region of Hungary that appeared to be iodine sufficient in previous studies. DESIGN: A cross-sectional voluntary screening study was organized in which 313 pregnant women participated. METHODS: Urine iodine concentration and the volume of the thyroid gland were measured in every woman. In the presence of low urinary iodine concentrations, goitre, or both, thyroid function tests were performed. RESULTS: Iodine deficiency was found in 57.1% of the pregnant women, and was severe in 15.6%. The volume of the thyroid gland was enlarged in 19.2% of individuals. Nodular goitre was found in 17 women (5.4%). The frequency of goitre and the mean thyroid volume were increased in the group of iodine-deficient women. In the 89 cases of iodine deficiency or goitre, thyrotrophin concentrations were in the normal range; however, the free triiodothyronine:free throxine ratio was increased in 97% of them, indicating that the thyroid gland was in a stimulated state in these individuals. CONCLUSIONS: Iodine deficiency with high prevalence of goitre was recognized among pregnant women in an area that previously appeared to be iodine sufficient. An unexpected mild iodine deficiency was also noted in the non-pregnant control group. Reassessment and continuous monitoring of iodine nutritional status is warranted even in populations that are apparently considered to be 'at no risk' of iodine deficiency, especially in pregnant women. Regular administration of iodine, starting at preconception or in early pregnancy and continuing during the period of nursing, is recommended in these regions.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal Of Endocrinology. - 143 : 4 (2000), p. 479-483. -
További szerzők:Molnár Ildikó (1953-) (belgyógyász, endokrin, immun- és allergológiai szakorvos) Jakab A. (orvos) Balogh E. Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Pákozdy Zsuzsanna Nagy P. Győry Ferenc (1964-) (sebész) Szabó J. (orvos) Bajnok László (1961-) (belgyógyász) Leövey András (1926-) (belgyógyász) Kakuk György (1938-2018) (belgyógyász) Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
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001-es BibID:BIBFORM030314
Első szerző:Nagy Endre V. (belgyógyász, endokrinológus)
Cím:Graves' ophthalmopathy : eye muscle involvement in patients with diplopia / Endre V. Nagy, Judit Toth, Ildiko Kaldi, Judit Damjanovich, Emese Mezosi, Agota Lenkey, Laszlo Toth, Jeno Szabo, Zsolt Karanyi, Andras Leovey
Dátum:2000
Megjegyzések:Background: Diplopia identifies patients with eye muscle involvement in Graves' ophthalmopathy (GO).Objective: To identify clinical parameters that could eliminate the need for magnetic resonance imaging(MRI) to assess the activity of inflammation in the eye muscles of GO patients with diplopia.Methods: In 43 patients with GO with recently developed diplopia, orbital ultrasound and MRI wereperformed. Muscle diameters and MRI T2 relaxation times were measured, and the amount of orbitalconnective tissue was calculated from MRI scans and compared with ultrasound readings, diplopiagrades, degree of protrusion, ocular pressure, tear production, antibody levels and hormonalparameters of thyroid function.Results: No correlation was found between diameters of 233 extraocular muscles measured by MRIand by ultrasound. For each of the four muscles, there was a diameter above which ultrasound wasalways unreliable. MRI data were used in further analysis. Of the muscles examined, the inferiorrectuses were the most frequently enlarged ? at least one, in 93% of cases. Medial, lateral and superiorrectuses were enlarged in 59%, 37% and 34% of the orbits respectively. The pattern of muscleinvolvement of the two orbits tended to be symmetric (r?0.49, P?0.003), particularly for the medialrectuses (r?0.90, P?0.000). Proptosis correlated with the sum of the muscle diameters for a giveneye (right eye: r?0.54, P?0.003; left eye: r?0.57, P?0.001), but it failed to correlate with theamount of orbital connective tissue. In 53% of the patients, normal T2 relaxation times were found inall eight muscles. There was only a weak correlation between muscle thickness and T2 relaxation time(r?0.49, P?0.003), indicating that muscle enlargement alone is not a sign of disease activity. Theseverity of diplopia was independent of T2 relaxation time. The amount of orbital connective tissueshowed a negative correlation with the greatest T2 relaxation time for a given eye (r? ?0.52,P?0.004); this suggests that disease types exist that have predominant muscle involvement andpredominant connective tissue expansion. No correlation between connective tissue expansion andproptosis, diplopia grade, muscle thickness or disease duration was found ? that is, connective tissueexpansion is not a major factor in diplopia. Both muscle and connective tissue findings wereindependent of thyroid function.Conclusion: Ultrasound and MRI eye muscle diameter readings do not correlate, because of the inherentinaccuracy of orbital ultrasound. Muscle enlargement alone does not mean oedematous swelling andactive disease. Neither ultrasound, nor any combination of 11 clinical and laboratory parametersprovided the degree of information on muscles and connective tissue that was obtainable by MRI. Inunclear cases of recently developed diplopia, before orbital decompression surgery, in the case oftreatment failure or if, for any other reason, imaging is needed in GO, MRI is the method of choice.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:European Journal of Endocrinology. - 142 : 6 (2000), p. 591-597. -
További szerzők:Tóth Judit Káldi Ildikó (szemész) Damjanovich Judit (1963-) (szemész) Mezősi Emese Lenkey Ágota (1944-) (biológus) Tóth László (1957-) (fül-orr-gégész) Szabó Jenő (belgyógyász, endocrinologus) Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Leövey András (1926-) (belgyógyász)
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3.

001-es BibID:BIBFORM017431
Első szerző:Szabó Jenő (belgyógyász, endocrinologus)
Cím:Heterogeneous signal pathways through TSH receptors in porcine thyroid cells following stimulation with Graves' immunoglobulin G. / Szabó J., Fóris G., Keresztes T., Csabina S., Varga Zs., Bakó Gy., Mezősi E., Nagy E., Paragh Gy., Leövey A.
Dátum:1998
Megjegyzések:We compared different signal transduction pathways through thyroid stimulating hormone receptor (TSH-R) in porcine thyroid cells (PTC) following stimulation with thyroid stimulating hormone (TSH) and 11 thyroid stimulating immunoglobulin samples (TSI) obtained from patients with Graves' disease. DESIGN: Following stimulation with TSI, the level of inositol trisphosphate (IP3) and [Ca2+]i, as well as the membrane bound protein kinase C (PKC) activity and the intensity of the arachidonic acid (AA) cascade, were determined in PTC. RESULTS: Seven out of eleven TSI samples activated PTC through IP3 generation, elevated [Ca2+]i from the intracellular pools, exhibited verapamil-insensitive membrane-bound PKC activation, and enhanced release of [14C]AA derivates (however, one of the samples was also able to take up Ca2+ from the extracellular space). Four out of eleven TSI samples did not activate the phospholipase C (PLC) system in which case the Ca2+ signal occurred only in the presence of extracellular Ca2+, the membrane bound PKC activation was verapamil sensitive, and in two of these four TSI samples, the AA release was extremely high. CONCLUSIONS: The simultaneous examination of the majority of the known signal pathways using TSI samples showed that TSI samples from different patients activate thyroid cells through different pathways. Their effects differ from that of TSH and, to a certain extent, from each other. The results give a certain new insight into the intracellular mechanisms exerted by TSI.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal of Endocrinology. - 139 : 3 (1998), p. 355-358. -
További szerzők:Fóris Gabriella (1937-) (belgyógyász) Keresztes Tamás Csabina Sándor Varga Zsuzsa (1951-) (biokémikus, nephrológus) Bakó Gyula (1951-) (belgyógyász) Mezősi Emese Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Paragh György (1953-) (belgyógyász) Leövey András (1926-) (belgyógyász)
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