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001-es BibID:	BIBFORM106441
Első szerző:	Frendl István (baleseti sebész és kézsebész)
Cím:	Alcohol consumption affects the late endocrine consequences of mild traumatic brain injury / Istvan Frendl, Annamaria Erdei, Noemi Zsiros, Monika Katko, Erika Galgoczi, Zoltan Nemeti, Harjit Pal Bhattoa, Janos Kappelmayer, Janos Posta, Bela Turchanyi, Ferenc Urban, Endre V. Nagy
Dátum:	2022
ISSN:	0172-780X
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Neuroendocrinology Letters. - 43 : 4 (2022), p. 239-245. -
További szerzők:	Erdei Annamária (1976-) (belgyógyász) Zsíros Noémi (1986-) (belgyógyász) Katkó Mónika (1980-) (biológus) Galgóczi Erika (1986-) (biológus) Németi Zoltán Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Kappelmayer János (1960-) (laboratóriumi szakorvos) Posta János (1964-) (vegyész, toxikológus) Turchányi Béla (1957-) (traumatológus) Urbán Ferenc Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM070757
Első szerző:	Frendl István (baleseti sebész és kézsebész)
Cím:	Plasminogen Activator Inhibitor Type 1 : a Possible Novel Biomarker of Late Pituitary Dysfunction after Mild Traumatic Brain Injury / Istvan Frendl, Monika Katko, Erika Galgoczi, Judit Boda, Noemi Zsiros, Zoltan Nemeti, Zsuzsanna Bereczky, Renata Hudak, Janos Kappelmayer, Annamaria Erdei, Bela Turchanyi, Endre V. Nagy
Dátum:	2017
ISSN:	0897-7151
Megjegyzések:	More than 80% of head trauma patients suffer from mild traumatic brain injury (mTBI). However, even mTBI carries the risk of late pituitary dysfunction. A predictive biomarker at the time of injury which could identify patients who subsequently may develop permanent pituitary dysfunction would help to direct patients towards endocrine care. We enrolled 508 traumatic brain injury patients (406 with mTBI) into our study. Blood samples were collected for identification of predictive biomarkers of late pituitary dysfunction at the time of admission. Follow-up blood samples were collected between 6 to 12 months after the head trauma and were evaluated for pituitary function. Of the 406 mTBI patients, 76 were available for follow-up. Pre-existing mild pituitary dysfunction was found for 15 patients based on hormone levels at the time of injury. Of the remaining 61 patients, 10 have shown deficiency in at least one pituitary hormone: 4 had growth hormone deficiency, 3 gonadotropin, 2 thyrotropin, and 1 patient combined gonadotropin and thyrotropin deficiency. Hence, newly developed pituitary hormone deficiency was found in 16% of mTBI patients. Neither the cause of mTBI nor its complications were predictive of late pituitary dysfunction. Of the haemostasis parameters studied, lower PAI-1 level at the time of injury was found to be predictive for the development of late pituitary dysfunction; sensitivity, specificity, positive and negative predictive values were 80%, 67%, 32% and 94%, respectively. Even mild TBI carries a substantial risk of endocrine consequences. Serum PAI-1 level at the time of head trauma may serve as predictive biomarker of late pituitary dysfunction in mTBI patients.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal Of Neurotrauma. - 34 : 23 (2017), p. 3238-3244. -
További szerzők:	Katkó Mónika (1980-) (biológus) Galgóczi Erika (1986-) (biológus) Boda Judit (belgyógyász, endokrinológus) Zsíros Noémi (1986-) (belgyógyász) Németi Zoltán Bereczky Zsuzsanna (1974-) (orvosi laboratóriumi diagnosztika szakorvos) Hudák Renáta Kappelmayer János (1960-) (laboratóriumi szakorvos) Erdei Annamária (1976-) (belgyógyász) Turchányi Béla (1957-) (traumatológus) Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM102086
035-os BibID:	(cikkazonosító)e0268525 (WOS)000835048800009 (Scopus)85130851932
Első szerző:	Molnár Csilla (aneszteziológus)
Cím:	Takotsubo cardiomyopathy in patients suffering from acute non-traumatic subarachnoid hemorrhage : A single center follow-up study / Molnár Csilla, Gál Judit, Szántó Dorottya, Fülöp László, Szegedi Andrea, Siró Péter, Nagy V. Endre, Lengyel Szabolcs, Kappelmayer János, Fülesdi Bela
Dátum:	2022
ISSN:	1932-6203
Megjegyzések:	Background Takotsubo cardiomyopathy (TTC) is an important complication of subarachnoid hemorrhage (SAH), that may delay surgical or endovascular treatment and may influence patient outcome. This prospective follow-up study intended to collect data on the prevalence, severity, influencing factors and long-term outcome of TTC in patients suffering from non-traumatic SAH. Methods Consecutive patients admitted with the diagnosis of non-traumatic SAH were included. Intitial assessment consisted of cranial CT, Hunt-Hess, Fisher and WFNS scoring, 12-lead ECG, transthoracic echocardiography (TTE), transcranial duplex sonography and collecting laboratory parameters (CK, CK-MB, cardiac troponin T, NT-proBNP and urine metanephrine and normetanephrine). Diagnosis of TTC was based on modified Mayo criteria. TTC patients were dichotomized to mild and severe forms. Follow-up of TTE, Glasgow Outcome Scale assessment, Barthel's and Karnofsky scoring occurred on days 30 and 180. Results One hundred thirty six patients were included. The incidence of TTC in the entire cohort was 28.7%; of them, 20.6% and 8.1% were mild and severe, respectively. TTC was more frequent in females (30/39; 77%) than in males (9/39; 23%) and was more severe. The occurrence of TTC was related to mFisher scores and WFNS scores. Although the severity of TTC was related to mFisher score, Hunt-Hess score, WFNS score and GCS, multivariate analysis showed the strongest relationship with mFisher scores. Ejection fraction differences between groups were present on day 30, but disappeared by day 180, whereas wall motion score index was still higher in the severe TTC group at day 180. By the end of the follow-up period (180 days), 70 (74.5%) patients survived in the non-TTC, 22 (81.5%) in the mild TTC and 3 (27%) in the severe TTC group (n = 11) (p = 0.002). At day 180, GOS, Barthel, and Karnofsky outcome scores were higher in patients in the control (non-TTC) and the mild TTC groups than in the severe TTC group. Conclusions Takotsubo cardiomyopathy is a frequent finding in patients with SAH, and severe TTC may be present in 8% of SAH cases. The severity of TTC may be an independent predictor of mortality and outcome at 6 months after disease onset. Therefore, a regular follow-up of ECG and TTE abnormalities is warranted in patients with subrachnoid hemorrhage for early detection of TTC.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Plos One. - 17 : 5 (2022), p. 1-20. -
További szerzők:	Gál Judit (1977-) (aneszteziológiai és ITO szakorvos) Szántó Dorottya (1991-) (aneszteziológus, intenzív terápiás szakorvos) Fülöp László (1976-) (kardiológus) Szegedi Andrea (kardiológus) Siró Péter (1973-) (neurológus, aneszteziológus, intenzív terápiás szakorvos) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Lengyel Szabolcs (1981-) (belgyógyász) Kappelmayer János (1960-) (laboratóriumi szakorvos) Fülesdi Béla (1961-) (aneszteziológus)
Pályázati támogatás:	Nemzeti Agykutatási Projekt Egyéb
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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