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001-es BibID:	BIBFORM115438
035-os BibID:	(cikkazonosító)40 (scopus)85173593022 (wos)001082009400001
Első szerző:	Cassemiro, Jessica F.
Cím:	Use of thyroid hormones in hypothyroid and euthyroid patients : a 2022 THESIS questionnaire survey of members of the Latin American Thyroid Society (LATS) / Cassemiro Jessica F., Ilera Veronica, Batalles Stella, Reyes Adriana, Nagy Endre V., Papini Enrico, Perros Petros, Hegedüs Laszlo, Ramos Helton Estrela
Dátum:	2023
ISSN:	1756-6614
Megjegyzések:	Purpose Inconsistencies in the medical management of hypothyroidism have been reported between endocrinologists in different countries. This study aimed to identify the attitudes of Latin America thyroid specialists towards the use of thyroid hormones. Methods Online survey of members of the Latin America Thyroid Society. Results 81/446 (18.2%) completed the questionnaire. Levothyroxine (LT4) was the initial treatment of choice for all respondents. 56.8% would consider LT4 use in biochemically euthyroid patients: infertile women with elevated anti-thyroid antibodies (46.9%), resistant depression (17.3%) and growing goiter (12%). Most respondents preferred tablets (39.5%) over liquid formulations (21.0%) or soft gel capsules (22.2%) and would not consider switching formulations in patients with persistent symptoms. 39.5% would never use LT4+liothyronine (LT3) combination therapy in symptomatic euthyroid patients, due to low quality evidence for benefit. 60.5% reported that persistence of symptoms despite normal TSH is rare (below 5% of patients) and its prevalence has been stable over the last five years. Psychosocial factors (84.0%), comorbidities (86.4%) and the patient unrealistic expectation (72.8%) were considered the top three explanations for this phenomenon. Conclusion LT4 tablets is the treatment of choice for hypothyroidism. A significant proportion of respondents would use LT4 in some groups of euthyroid individuals, contrasting the recommendations of the major clinical practice guideline indications. LT4+LT3 combination treatment in euthyroid symptomatic patients was considered by nearly 50%. Practices based on weak or absent evidence included use of thyroid hormones for euthyroid subjects by 56.8% of respondents and use of LT4+LT3 treatment by 60.5% of respondents for patients with persistent symptoms. In contrast to many European countries, LATS respondents report a low and unchanged proportion of dissatisfied patients over the last five years.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Thyroid Research. - 16 : 1 (2023), p. 1-9. -
További szerzők:	Ilera, Veronica Batalles, Stella Reyes, Adriana Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Papini, Enrico Perros, Petros Hegedűs László Dávid (1992-) (PhD hallgató) Ramos, Helton Estrela
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001-es BibID:	BIBFORM116667
035-os BibID:	(Scopus)85170843236 (WOS)001015187100005 (cikkazonosító)e220134
Első szerző:	Solymosi Tamás
Cím:	Considerable interobserver variation calls for unambiguous definitions of thyroid nodule ultrasound characteristics / Solymosi Tamas, Hegedűs Laszlo, Bonnema Steen J., Frasoldati Andrea, Jambor Laszlo, Karanyi Zsolt, Kovacs Gabor L., Papini Enrico, Rucz Karoly, Russ Gilles, Nagy Endre V.
Dátum:	2023
ISSN:	2235-0640 2235-0802
Megjegyzések:	Thyroid nodule ultrasound characteristics are used as an indication for fine-needle aspiration cytology, usually as the basis for Thyroid Imaging Reporting and Data System (TIRADS) score calculation. Few studies on interobserver variation are available, all of which are based on analysis of preselected still ultrasound images and often lack surgical confirmation.Methods: After the blinded online evaluation of video recordings of the ultrasound examinations of 47 consecutive malignant and 76 consecutive benign thyroid lesions, 7 experts from 7 thyroid centers answered 17 TIRADS-related questions. Surgical histology was the reference standard. Interobserver variations of each ultrasound characteristic were compared using Gwet's AC1 inter-rater coefficients; higher values mean better concordance, the maximum being 1.0.Results: On a scale from 0.0 to 1.0, the Gwet's AC1 values were 0.34, 0.53, 0.72, and 0.79 for the four most important features in decision-making, i.e. irregular margins, microcalcifications, echogenicity, and extrathyroidal extension, respectively. The concordance in the discrimination between mildly/moderately and very hypoechogenic nodules was 0.17. The smaller the nodule size the better the agreement in echogenicity, and the larger the nodule size the better the agreement on the presence of microcalcifications. Extrathyroidal extension was correctly identified in just 45.8% of the cases.Conclusions: Examination of video recordings, closely simulating the real-world situation, revealed substantial interobserver variation in the interpretation of each of the four most important ultrasound characteristics. In view of the importance for the management of thyroid nodules, unambiguous and widely accepted definitions of each nodule characteristic are warranted, although it remains to be investigated whether this diminishes observer variation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk cytology thyroid cancer thyroid nodule TIRADS ultrasound
Megjelenés:	European Thyroid Journal. - 12 : 2 (2023), p. 1-11. -
További szerzők:	Hegedűs László Dávid (1992-) (PhD hallgató) Bonnema, Steen Joop Frasoldati, Andrea Jámbor László (1960-) (radiológus) Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Kovács Gábor L. (Szeged) Papini, Enrico Rucz Károly Russ, Gilles Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
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