CCL

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001-es BibID:BIBFORM015938
Első szerző:Glant Tibor T.
Cím:Disease-associated qualitative and quantitative trait loci in proteoglycan-induced arthritis and collagen-induced arthritis / T. T. Glant, V. A. Adarichev, A. B. Nesterovitch, S. Szanto, J. P. Oswald, J. J. Jacobs, G. Firneisz, J. Zhang, A. Finnegan, K. Mikecz
Dátum:2004
ISSN:0002-9629 (Print)
Megjegyzések:Two autoimmune murine models--proteoglycan (aggrecan)-induced arthritis (PGIA) and collagen-induced arthritis (CIA)--were developed in parent strains, F1 and F2 hybrids of major histocompatibility complex (MHC)-matched (H-2) BALB/c x DBA/2 and MHC-unmatched (H-2/H-2) BALB/c x DBA/1 intercrosses. The major goal of this comparative study was to identify disease (model)-specific (PGIA or CIA) and shared clinical and immunologic loci in 2 types of genetic intercrosses. Qualitative (binary/susceptibility) and quantitative (severity and onset) clinical trait loci were separated and analyzed independently or together with various pathophysiologic/immunologic traits, such as antigen-specific T- and B-cell responses and cytokine production. The major quantitative trait locus (QTL) was the MHC on chromosome 17, which was especially dominant in CIA. In addition, chromosomes 3, 5, 10, and X contained shared clinical loci in both models, and a total of 8 QTLs (clinical traits together with immunologic traits) were colocalized in PGIA and CIA.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Animals
Antibodies/immunology/metabolism
Arthritis, Experimental/*genetics/*immunology
Arthritis, Rheumatoid/chemically induced/*genetics/*immunology
Cytokines/immunology/metabolism
Disease Susceptibility
Genetic Linkage
Humans
Major Histocompatibility Complex
Mice
Mice, Inbred BALB C
Mice, Inbred DBA
Proteoglycans/immunology/*toxicity
*Quantitative Trait Loci
T-Lymphocytes/immunology/metabolism
Megjelenés:The American journal of the medical sciences. - 327 : 4 (2004), p. 188-95. -
További szerzők:Adarichev, Vyacheslav A. Nesterovitch, Andrew B. Szántó Sándor (1968-) (belgyógyász, reumatológus) Oswald, J. P. Jacobs, Joshua J. Firneisz Gábor Zhang, J. Finnegan, Alison Mikecz Katalin
Internet cím:elektronikus változat
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