Találati lista | Tudóstér

001-es BibID:	BIBFORM096575
035-os BibID:	(cikkazonosító)8174 (scopus)85111357537 (wos)000681839700001
Első szerző:	Balla József (belgyógyász, nephrológus)
Cím:	Heme Burden and Ensuing Mechanisms That Protect the Kidney : insights from Bench and Bedside / Balla József, Zarjou Abolfazl
Dátum:	2021
ISSN:	1661-6596 1422-0067
Megjegyzések:	With iron at its core, the tetrapyrrole heme ring is a cardinal prosthetic group made up of many proteins that participate in a wide array of cellular functions and metabolism. Once released, due to its pro-oxidant properties, free heme in sufficient amounts can result in injurious effects to the kidney and other organs. Heme oxygenase-1 (HO-1) has evolved to promptly attend to such injurious potential by facilitating degradation of heme into equimolar amounts of carbon monoxide, iron, and biliverdin. HO-1 induction is a beneficial response to tissue injury in diverse animal models of diseases, including those that affect the kidney. These protective attributes are mainly due to: (i) prompt degradation of heme leading to restraining potential hazardous effects of free heme, and (ii) generation of byproducts that along with induction of ferritin have proven beneficial in a number of pathological conditions. This review will focus on describing clinical aspects of some of the conditions with the unifying end-result of increased heme burden and will discuss the molecular mechanisms that ensue to protect the kidneys.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	International Journal Of Molecular Sciences. - 22 : 15 (2021), p. 1-16. -
További szerzők:	Zarjou, Abolfazl (1979-) (kutató orvos)
Pályázati támogatás:	132828 OTKA GINOP-2.3.2-15-2016-00043 GINOP 11003 MTA ED_18-1-2019-0028 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM106058
035-os BibID:	(cikkazonosító)8300 (scopus)85137089192 (wos)000840221800001
Első szerző:	Machado, Sarah E.
Cím:	Counteraction of Myocardial Ferritin Heavy Chain Deficiency by Heme Oxygenase-1 / Machado Sarah E., Spangler Daryll, Stacks Delores A., Darley-Usmar Victor, Benavides Gloria A., Xie Min, Balla József, Zarjou Abolfazl
Dátum:	2022
ISSN:	1422-0067
Megjegyzések:	Given the abundance of heme proteins (cytochromes) in the mitochondrion, it is evident that a meticulously orchestrated iron metabolism is essential for cardiac health. Here, we examined the functional significance of myocardial ferritin heavy chain (FtH) in a model of acute myocardial infarction. We report that FtH deletion did not alter either the mitochondrial regulatory and surveillance pathways (fission and fusion) or mitochondrial bioenergetics in response to injury. Furthermore, deletion of myocardial FtH did not affect cardiac function, assessed by measurement of left ventricular ejection fraction, on days 1, 7, and 21 post injury. To identify the modulated pathways providing cardiomyocyte protection coincident with FtH deletion, we performed unbiased transcriptomic analysis. We found that following injury, FtH deletion was associated with upregulation of several genes with anti-ferroptotic properties, including heme oxygenase-1 (HO-1) and the cystine/glutamate anti-porter (Slc7a11). These results suggested that HO-1 overexpression mitigates ferroptosis via upregulation of Slc7a11. Indeed, using transgenic mice with HO-1 overexpression, we demonstrate that overexpressed HO-1 is coupled with increased Slc7a11 expression. In conclusion, we demonstrate that following injury, myocardial FtH deletion leads to a compensatory upregulation in a number of anti-ferroptotic genes, including HO-1. Such HO-1 induction leads to overexpression of Slc7a11 and protects the heart against ischemia-reperfusion-mediated ferroptosis, preserves mitochondrial function, and overall function of the myocardium.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	International Journal Of Molecular Sciences. - 23 : 15 (2022), p. 1-17. -
További szerzők:	Spangler, Daryll Stacks, Delores A. Darley-Usmar, Victor Benavides, Gloria A. Xie, Min Balla József (1959-) (belgyógyász, nephrológus) Zarjou, Abolfazl (1979-) (kutató orvos)
Pályázati támogatás:	TKP2021-EGA-20 Egyéb OTKA-132828 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: