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001-es BibID:BIBFORM010313
Első szerző:Zsíros Emese (orvos)
Cím:Developmental switch of the expression of ion channels in human dendritic cells / Zsiros Emese, Kis-Tóth Katalin, Hajdú Péter, Gáspár Rezső, Joanna Bielansk, Antonio Felipe, Rajnavölgyi Éva, Panyi György
Dátum:2009
ISSN:0022-1767
Megjegyzések:Modulation of the expression and activity of plasma membrane ion channels is one of the mechanisms by which immune cells can regulate their intracellular Ca2(+) signaling pathways required for proliferation and/or differentiation. Voltage-gated K+ channels, inwardly rectifying K+ channels, and Ca2+-activated K+ channels have been described to play a major role in controlling the membrane potential in lymphocytes and professional APCs, such as monocytes, macrophages, and dendritic cells (DCs). Our study aimed at the characterization and identification of ion channels expressed in the course of human DC differentiation from monocytes. We report in this study for the first time that immature monocyte-derived DCs express voltage-gated Na+ channels in their plasma membrane. The analysis of the biophysical and pharmacological properties of the current and PCR-based cloning revealed the presence of Nav1.7 channels in immature DCs. Transition from the immature to a mature differentiation state, however, was accompanied by the down-regulation of Nav1.7 expression concomitant with the up-regulation of voltage-gated Kv1.3 K+ channel expression. The presence of Kv1.3 channels seems to be common for immune cells; hence, selective Kv1.3 blockers may emerge as candidates for inhibiting various functions of mature DCs that involve their migratory, cytokine-secreting, and T cell-activating potential.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Union of Pharmacology
Dependent K+ channel
Human Lymhocytes T
Potassium channels
Sodium Channels
Electrophysiological properties
Peripheral nerve
Immune system
Macrophages
Activation
Megjelenés:The Journal of Immunology 183 : 7 (2009), p. 4483-4492. -
További szerzők:Kis-Tóth Katalin (1975-) (immunológus) Hajdu Péter (1975-) (biofizikus) Gáspár Rezső (1944-) (biofizikus) Bielansk, Joanna Felipe, Antonio Rajnavölgyi Éva (1950-) (immunológus) Panyi György (1966-) (biofizikus)
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