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001-es BibID:	BIBFORM019359
Első szerző:	Hajdu János
Cím:	Is the presence of distant metastasis associated with c-myc amplification in gastric cancer? / J. Hajdú, L. Kozma, I. Kiss, Zs. Szentkereszty, Sz. Szakáll, I. Ember
Dátum:	1997
Megjegyzések:	The expression of the c-myc oncogenes has already been reported in human gastric carcinoma. Overexpression can be the consequence of oncogene amplification and often correlates with different prognostic factors. Authors investigated the value of c-myc oncogene amplification in 23 patients (9 male, 14 female, aged 28-85 yrs) with gastric cancer and its correlation to the following clinical and histopathological parameters: grade, TNM stage, Lauren's type, localisation and severity of disease. DNA was isolated from formalin-fixed, paraffin embedded tissue for quantitative dot-blot hybridisation. Amplified c-myc was found in 6 out of 23 cases. Its values ranged from 2.12 up to 18.2 (average 9.1). Significant association was found between the presence of c-myc amplification and distant metastasis (corr. coeff.: 0.5623, p < 0.01). High scores of the other parameters also correlated with c-myc, albeit not significantly. The result of cluster analysis, based on the similarity of the parameter values for the individual patients proved that the age was the decisive factor in creating two groups. The distribution of patients into these groups did not seem to coincide with the presence of c-myc amplification or distant metastasis, inspite of the proved correlation between them.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban folyóiratcikk
Megjelenés:	Acta Chirurgica Hungarica. - 36 : 1-4 (1997), p. 119-121. -
További szerzők:	Kozma László (orvos) Kiss István Szentkereszty Zsolt (1961-) (sebész) Szakáll Szabolcs Ember István
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM024484
Első szerző:	Kozma László (orvos)
Cím:	C-myc amplification and cluster analysis in human gastric carcinoma / László Kozma, István Kiss, Jenő Hajdú, Zsolt Szentkereszty, Szabolcs Szakáll, István Ember
Dátum:	2001
ISSN:	0250-7005
Megjegyzések:	The tumour samples ot 23 patients (9 male, 14 female, aged 28-85) were randomly selected for the study. DNA was isolated from paraffin embedded tissue for quantitative dot-blot hybridization, in order to determine the amplification values for the c-myc and K-ras oncogenes. The clinical and histological parameters studied were as follows: grade, TNM staging system, Lauren's histological type, localization and the severity of the disease. Amplified c-myc was found in 6 cases. Amplification was concomitant with c-myc overexpression detected with immunohistochemical staining. The amplification--9.1-fold on the average (ranging from 2.12 to 18.2) was significantly associated with the presence of distant metastasis (corr. coeff.: 0.5623, p < 0.01), but with none of the other parameters. No case with K-ras amplification was recorded. The result of the multivariate cluster analysis proved that age was the decisive factor in the segregation process. This age-related distribution (69 vs. 40, p < 0.001), however, did not coincide with either the incidence of distant metastasis or c-myc amplification.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Anticancer Research. - 21 : 1B (2001), p. 707-710. -
További szerzők:	Kiss István (Pécs) Hajdu Jenő Szentkereszty Zsolt (1961-) (sebész) Szakáll Szabolcs Ember István
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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