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1.
001-es BibID:
BIBFORM083560
035-os BibID:
(WOS)000574394600030 (Scopus)85078897832
Első szerző:
Brito-Zerón, Pilar
Cím:
Epidemiological profile and north-south gradient driving baseline systemic involvement of primary Sjögren's syndrome / Pilar Brito-Zerón, Nihan Acar-Denizli, Wan-Fai Ng, Ildiko Fanny Horváth, Astrid Rasmussen, Raphaele Seror, Xiaomei Li, Chiara Baldini, Jacques-Eric Gottenberg, Debashish Danda, Luca Quartuccio, Roberta Priori, Gabriela Hernandez-Molina, Berkan Armagan, Aike A. Kruize, Seung-Ki Kwok, Marika Kvarnstrom, Sonja Praprotnik, Damien Sene, Roberto Gerli, Roser Solans, Maureen Rischmueller, Thomas Mandl, Yasunori Suzuki, David Isenberg, Valeria Valim, Piotr Wiland, Gunnel Nordmark, Guadalupe Fraile, Hendrika Bootsma, Hideki Nakamura, Roberto Giacomelli, Valerie Devauchelle-Pensec, Benedikt Hofauer, Michele Bombardieri, Virginia Fernandes Moça Trevisani, Daniel Hammenfors, Sandra G. Pasoto, Soledad Retamozo, Tamer A. Gheita, Fabiola Atzeni, Jacques Morel, Cristina Vollenweider, Margit Zeher, Kathy Sivils, Bei Xu, Stefano Bombardieri, Pulukool Sandhya, Salvatore De Vita, Antonina Minniti, Jorge Sánchez-Guerrero, Levent Kilic, Eefje van der Heijden, Sung-Hwan Park, Marie Wahren-Herlenius, Xavier Mariette, Manuel Ramos-Casals, Sjögren Big Data Consortium
Dátum:
2020
ISSN:
1462-0324 1462-0332
Megjegyzések:
OBJECTIVE: To characterize the systemic phenotype of primary Sjögren's syndrome at diagnosis by analysing the EULAR-SS disease activity index (ESSDAI) scores. METHODS: The Sjögren Big Data Consortium is an international, multicentre registry based on worldwide data-sharing cooperative merging of pre-existing databases from leading centres in clinical research in Sjögren's syndrome from the five continents. RESULTS: The cohort included 10 007 patients (9352 female, mean 53?years) with recorded ESSDAI scores available. At diagnosis, the mean total ESSDAI score was 6.1; 81.8% of patients had systemic activity (ESSDAI score ?1). Males had a higher mean ESSDAI (8.1 vs 6.0, P?<?0.001) compared with females, as did patients diagnosed at <35?years (6.7 vs 5.6 in patients diagnosed at >65?years, P?<?0.001). The highest global ESSDAI score was reported in Black/African Americans, followed by White, Asian and Hispanic patients (6.7, 6.5, 5.4 and 4.8, respectively; P?<?0.001). The frequency of involvement of each systemic organ also differed between ethnic groups, with Black/African American patients showing the highest frequencies in the lymphadenopathy, articular, peripheral nervous system, CNS and biological domains, White patients in the glandular, cutaneous and muscular domains, Asian patients in the pulmonary, renal and haematological domains and Hispanic patients in the constitutional domain. Systemic activity measured by the ESSDAI, clinical ESSDAI (clinESSDAI) and disease activity states was higher in patients from southern countries (P?<?0.001). CONCLUSION: The systemic phenotype of primary Sjögren's syndrome is strongly influenced by personal determinants such as age, gender, ethnicity and place of residence, which are key geoepidemiological players in driving the expression of systemic disease at diagnosis.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
ethnicity
gender
geoepidemiology
phenotype
primary Sjögren's syndrome
Megjelenés:
Rheumatology. - 59 : 9 (2020), p. 2350-2359. -
További szerzők:
Acar-Denizli, Nihan
Ng, Wan Fai
Horváth Ildikó Fanny (1980-) (belgyógyász, allergológus, klinikai immunológus)
Rasmussen, Astrid
Seror, Raphaele
Li, Xiaomei
Baldini, Chiara
Gottenberg, Jacques-Eric
Danda, Debashish
Quartuccio, Luca
Priori, Roberta
Hernandez-Molina, Gabriela
Armagan, Berkan
Kruize, Aike A.
Kwok, Seung-Ki
Kvarnstrom, Marika
Praprotnik, Sonja
Sene, Damien
Gerli, Roberto
Solans, Roser
Rischmueller, Maureen
Mandl, Thomas
Suzuki, Yasunori
Isenberg, David A.
Valim, Valeria
Wiland, Piotr
Nordmark, Gunnel
Fraile, Guadalupe
Bootsma, Hendrika
Nakamura, Hideki
Giacomelli, Roberto
Devauchelle-Pensec, Valerie
Hofauer, Benedikt
Bombardieri, Michele
Trevisani, Virginia Fernandes Moça
Hammenfors, Daniel
Pasoto, Sandra
Retamozo, Soledad
Gheita, Tamer A.
Atzeni, Fabiola
Morel, Jacques
Vollenveider, Cristina
Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Sivils, Kathy
Xu, Bei
Bombardieri, Stefano
Sandhya, Pulukool
Vita, Salvatore de
Minniti, Antonina
Sanchez-Guerrero, Jorge
Kilic, Levent
Heijden, Eefje van der
Park, Sung-Hwan
Wahren-Herlenius, Marie
Mariette, Xavier
Ramos-Casals, Manuel
Sjögren Big Data Consortium
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
2.
001-es BibID:
BIBFORM074743
035-os BibID:
(WOS)000446486100015 (Scopus)85055613559
Első szerző:
Brito-Zerón, Pilar
Cím:
How immunological profile drives clinical phenotype of primary Sjögren's syndrome at diagnosis : analysis of 10,500 patients (Sjögren Big Data Project) / P. Brito-Zerón, N. Acar-Denizli, W. F. Ng, M. Zeher, A. Rasmussen, T. Mandl, R. Seror, X. Li, C. Baldini, Jacques-Eric Gottenberg, D. Danda, L. Quartuccio, R. Priori, G. Hernandez-Molina, B. Armagan, A. A. Kruize, Seung-Ki Kwok, M. Kvarnström, S. Praprotnik, D. Sène, E. Bartoloni, R. Solans, M. Rischmueller, Y. Suzuki, D. A. Isenberg, V. Valim, P. Wiland, G. Nordmark, G. Fraile, H. Bootsma, T. Nakamura, R. Giacomelli, V. Devauchelle-Pensec, A. Knopf, M. Bombardieri, V. Trevisani, D. Hammenfors, S. Pasoto, S. Retamozo, T. A. Gheita, F. Atzeni, J. Morel, C. Vollenveider, I. Horvath, K. Sivils, P. Olsson, S. De Vita, J. Sánchez-Guerrero, L. Kilic, M. Wahren-Herlenius, X. Mariette, M. Ramos-Casals, Sjögren Big Data Consortium
Dátum:
2018
ISSN:
0392-856X
Megjegyzések:
OBJECTIVES:To evaluate the influence of the main immunological markers on the disease phenotype at diagnosis in a large international cohort of patients with primary Sjögren's syndrome (SjS). METHODS:The Big Data Sjögren Project Consortium is an international, multicentre registry created in 2014. As a first step, baseline clinical information from leading centres on clinical research in SjS of the 5 continents was collected. The centres shared a harmonised data architecture and conducted cooperative online efforts in order to refine collected data under the coordination of a big data statistical team. Inclusion criteria were the fulfillment of the 2002 classification criteria. Immunological tests were carried out using standard commercial assays. RESULTS:By January 2018, the participant centres had included 10,500 valid patients from 22 countries. The cohort included 9,806 (93%) women and 694 (7%) men, with a mean age at diagnosis of primary SjS of 53 years, mainly White (78%) and included from European countries (71%). The frequency of positive immunological markers at diagnosis was 79.3% for ANA, 73.2% for anti-Ro, 48.6% for RF, 45.1% for anti- La, 13.4% for low C3 levels, 14.5% for low C4 levels and 7.3% for cryoglobulins. Positive autoantibodies (ANA, Ro, La) correlated with a positive result in salivary gland biopsy, while hypocomplementaemia and especially cryoglo-bulinaemia correlated with systemic activity (mean ESSDAI score of 17.7 for cryoglobulins, 11.3 for low C3 and 9.2 for low C4, in comparison with 3.8 for negative markers). The immunological markers with a great number of statistically-significant associations (p<0.001) in the organ-by-organ ESS- DAI evaluation were cryoglobulins (9 domains), low C3 (8 domains), anti-La (7 domains) and low C4 (6 domains). CONCLUSIONS:We confirm the strong influence of immunological markers on the phenotype of primary SjS at diagnosis in the largest multi-ethnic international cohort ever analysed, with a greater influence for cryoglobulinaemic-related markers in comparison with Ro/La autoantibodies and ANA. Immunological patterns play a central role in the phenotypic expression of the disease already at the time of diagnosis, and may guide physicians to design a specific personalised management during the follow-up of patients with primary SjS.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
primary Sjögren's syndrome
salivary gland biopsy
Ro/La autoantibodies
hypocomplementaemia
cryoglobulinaemia
ESSDAI
Megjelenés:
Clinical and Experimental Rheumatology. - 36 : Suppl. 112 (2018), p. S102-S112. -
További szerzők:
Acar-Denizli, Nihan
Ng, Wan Fai
Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Rasmussen, Astrid
Mandl, Thomas
Seror, Raphaele
Li, X.
Baldini, Chiara
Gottenberg, Jacques-Eric
Danda, Debashish
Quartuccio, Luca
Priori, Roberta
Hernandez-Molina, Gabriela
Armagan, Berkan
Kruize, Aike A.
Kwok, Seung-Ki
Kvarnstrom, Marika
Praprotnik, Sonja
Sene, Damien
Bartoloni, Elena
Solans, Roser
Rischmueller, Maureen
Suzuki, Yasunori
Isenberg, David A.
Valim, Valeria
Wiland, Piotr
Nordmark, Gunnel
Fraile, Guadalupe
Bootsma, Hendrika
Nakamura, T.
Giacomelli, Roberto
Devauchelle-Pensec, Valerie
Knopf, A.
Bombardieri, Michele
Trevisani, Virginia Fernandes Moça
Hammenfors, Daniel
Pasoto, Sandra
Retamozo, Soledad
Gheita, Tamer A.
Atzeni, F.
Morel, Jacques
Vollenveider, Cristina
Horváth Ildikó Fanny (1980-) (belgyógyász, allergológus, klinikai immunológus)
Sivils, Kathy
Olsson, Peter
Vita, Salvatore de
Sanchez-Guerrero, Jorge
Kilic, Levent
Wahren-Herlenius, Marie
Mariette, Xavier
Ramos-Casals, Manuel
Sjögren Big Data Consortium
Internet cím:
Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
3.
001-es BibID:
BIBFORM069228
035-os BibID:
(WoS)000401138800017 (Scopus)85006013155
Első szerző:
Brito-Zerón, Pilar
Cím:
Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients : a cross-sectional study from the Big Data Sjögren Project Consortium / Pilar Brito-Zerón, Nihan Acar-Denizli, Margit Zeher, Astrid Rasmussen, Raphaele Seror, Elke Theander, Xiaomei Li, Chiara Baldini, Jacques-Eric Gottenberg, Debashish Danda, Luca Quartuccio, Roberta Priori, Gabriela Hernandez-Molina, Aike A. Kruize, Valeria Valim, Marika Kvarnstrom, Damien Sene, Roberto Gerli, Sonja Praprotnik, David Isenberg, Roser Solans, Maureen Rischmueller, Seung-Ki Kwok, Gunnel Nordmark, Yasunori Suzuki, Roberto Giacomelli, Valerie Devauchelle-Pensec, Michele Bombardieri, Benedikt Hofauer, Hendrika Bootsma, Johan G. Brun, Guadalupe Fraile, Steven E. Carsons, Tamer A. Gheita, Jacques Morel, Cristina Vollenveider, Fabiola Atzeni, Soledad Retamozo, Ildiko Fanny Horvath, Kathy Sivils, Thomas Mandl, Pulukool Sandhya, Salvatore De Vita, Jorge Sanchez-Guerrero, Eefje van der Heijden, Virginia Fernandes Moça Trevisani, Marie Wahren-Herlenius, Xavier Mariette, Manuel Ramos-Casals, EULAR-SS Task Force Big Data Consortium
Dátum:
2017
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:
Annals of the rheumatic diseases. - 76 : 6 (2017), p. 1042-1050. -
További szerzők:
Acar-Denizli, Nihan
Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Rasmussen, Astrid
Seror, Raphaele
Theander, Elke
Li, Xiaomei
Baldini, Chiara
Gottenberg, Jacques-Eric
Danda, Debashish
Quartuccio, Luca
Priori, Roberta
Hernandez-Molina, Gabriela
Kruize, Aike A.
Valim, Valeria
Kvarnstrom, Marika
Sene, Damien
Gerli, Roberto
Praprotnik, Sonja
Isenberg, David A.
Solans, Roser
Rischmueller, Maureen
Kwok, Seung-Ki
Nordmark, Gunnel
Suzuki, Yasunori
Giacomelli, Roberto
Devauchelle-Pensec, Valerie
Bombardieri, Michele
Hofauer, Benedikt
Bootsma, Hendrika
Brun, Johan G.
Fraile, Guadalupe
Carsons, Steven E.
Gheita, Tamer A.
Morel, Jacques
Vollenveider, Cristina
Atzeni, Fabiola
Retamozo, Soledad
Horváth Ildikó Fanny (1980-) (belgyógyász, allergológus, klinikai immunológus)
Sivils, Kathy
Mandl, Thomas
Sandhya, Pulukool
Vita, Salvatore de
Sanchez-Guerrero, Jorge
Heijden, Eefje van der
Fernandes Moça Trevisani, Virginia
Wahren-Herlenius, Marie
Mariette, Xavier
Ramos-Casals, Manuel
EULAR-SS Task Force Big Data Consortium
Internet cím:
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
4.
001-es BibID:
BIBFORM083561
035-os BibID:
(WOS)000488952900016 (Scopus)85071621125
Első szerző:
Retamozo, Soledad
Cím:
Systemic manifestations of primary Sjögren's syndrome out of the ESSDAI classification : prevalence and clinical relevance in a large international, multi-ethnic cohort of patients / S. Retamozo, N. Acar-Denizli, A. Rasmussen, I. F. Horváth, C. Baldini, R. Priori, P. Sandhya, G. Hernandez-Molina, B. Armagan, S. Praprotnik, M. Kvarnstrom, R. Gerli, A. Sebastian, R. Solans, M. Rischmueller, S. G. Pasoto, V. Valim, G. Nordmark, A. A. Kruize, H. Nakamura, B. Hofauer, R. Giacomelli, V. Fernandes Moça Trevisani, V. Devauchelle-Pensec, F. Atzeni, T. A. Gheita, S. Consani-Fernández, A. Szántó, K. Sivils, A. Gattamelata, D. Danda, L. Kilic, E. Bartoloni, S. Bombardieri, J. Sánchez-Guerrero, M. Wahren-Herlenius, X. Mariette, M. Ramos-Casals, P. Brito-Zerón, Sjögren Big Data Consortium
Dátum:
2019
ISSN:
0392-856X
Megjegyzések:
OBJECTIVES: To analyse the frequency and characterise the systemic presentation of primary Sjögren's syndrome (SS) out of the ESSDAI classification in a large international, multi-ethnic cohort of patients. METHODS: The Big Data Sjögren Project Consortium is an international, multicentre registry based on world-wide data-sharing and cooperative merging of pre-existing clinical SS databases from leading centres in clinical research in SS from the five continents. A list of 26 organ-by-organ systemic features not currently included in the ESSDAI classification was defined according to previous studies; these features were retrospectively recorded. RESULTS: Information about non-ESSDAI features was available in 6331 patients [5,917 female, mean age at diagnosis 52 years, mainly White (86.3%)]. A total of 1641 (26%) patients had at least one of the ESSDAI systemic features. Cardiovascular manifestations were the most frequent organ-specific group of non-ESSDAI features reported in our patients (17% of the total cohort), with Raynaud's phenomenon being reported in 15%. Patients with systemic disease due to non-ESSDAI features had a lower frequency of dry mouth (90.7% vs. 94.1%, p<0.001) and positive minor salivary gland biopsy (86.7% vs. 89%, p=0.033), a higher frequency of anti-Ro/SSA (74.7% vs. 68.7%, p<0.001), anti-La/SSB antibodies (44.5% vs. 40.4%, p=0.004), ANA (82.7% vs. 79.5%, p=0.006), low C3 levels (17.4% vs. 9.7%, p<0.001), low C4 levels (14.4% vs. 9.6%, p<0.001), and positive serum cryoglobulins (8.6% vs. 5.5%, p=0.001). Systemic activity measured by the ESSDAI, clinESSDAI and DAS was higher in patients with systemic disease out of the ESSDAI in comparison with those without these features (p<0.001 for all comparisons). CONCLUSIONS: More than a quarter of patients with primary SS may have systemic manifestations not currently included in the ESSDAI classification, with a wide variety of cardiovascular, digestive, pulmonary, neurological, ocular, ENT (ear, nose, and throat), cutaneous and urological features that increase the scope of the systemic phenotype of the disease. However, the individual frequency of each of these non-ESSDAI features was very low, except for Raynaud's phenomenon.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
primary Sjögren's syndrome
ESSDAI
Raynaud's phenomenon
pleuritis
pericarditis
uveitis
congenital heart block
pulmonary arterial hypertension
Megjelenés:
Clinical and Experimental Rheumatology. - 37 Suppl. 118 : 3 (2019), p. 97-106. -
További szerzők:
Acar-Denizli, Nihan
Rasmussen, Astrid
Horváth Ildikó Fanny (1980-) (belgyógyász, allergológus, klinikai immunológus)
Baldini, Chiara
Priori, Roberta
Sandhya, Pulukool
Hernandez-Molina, Gabriela
Armagan, Berkan
Praprotnik, Sonja
Kvarnstrom, Marika
Gerli, Roberto
Sebastian, Agata
Solans, Roser
Rischmueller, Maureen
Pasoto, Sandra
Valim, Valeria
Nordmark, Gunnel
Kruize, Aike A.
Nakamura, Hideki
Hofauer, Benedikt
Giacomelli, Roberto
Fernandes Moça Trevisani, Virginia
Devauchelle-Pensec, Valerie
Atzeni, F.
Gheita, Tamer A.
Consani-Fernández, S.
Szántó Antónia (1977-) (belgyógyász, allergológus és klinikai immunológus)
Sivils, Kathy
Gattamelata, Angelica
Danda, Debashish
Kilic, Levent
Bartoloni, Elena
Bombardieri, Stefano
Sanchez-Guerrero, Jorge
Wahren-Herlenius, Marie
Mariette, Xavier
Ramos-Casals, Manuel
Brito-Zerón, Pilar
Sjögren Big Data Consortium
Internet cím:
Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
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