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001-es BibID:	BIBFORM083567
035-os BibID:	(WoS)000480254003094
Első szerző:	Papp Gábor (belgyógyász)
Cím:	Investigation on the immunological effects of regular physical exercise / Papp Gábor, Szabó Krisztina, Jámbor Ilona, Mile Marianna, Csiki Zoltán, Balogh László
Dátum:	2019
ISSN:	0105-4538 1398-9995
Megjegyzések:	Background : Growing evidence shed light on the significant effects of physical activity on immunomodulation. Consequences may largely depend on the type of activity, its intensity and duration. However, little information is available regarding the immunological effects of sporting activities in older ages. The aim of our study was to examine the changes in a wide spectrum of lymphocyte subtypes after a period of regular workout among healthy women of different ages. Method : In a cross- sectional study, we enrolled 34 young adult women (between ages of 19- 23 years), 8 of them were a player of a team in Hungarian Women ' s Volleyball League, while 26 of them were not engaged in regular physical activity. Additionally, we enrolled 16 elderly women (between ages of 60- 75 years) not engaged in regular physical activity. During a follow- up study, 17 from the group of non- athlete young adults completed a 12- week Pilates workout program, while the group of elderly women took part in a 6- week lightweight conditioning gymnastic exercise program once a week. The percentages of peripheral natural killer (NK), NKT cells, T and B lymphocyte subtypes (early- /late- activated T, naive and memory T, cytotoxic T (Tc), T- helper (Th)1, Th2, Th17, T regulatory type 1 (Tr1), CD4 + CD127- CD25 bright Treg, as well as naive and memory B cells) were determined by flow cytometry based on the staining of extracellular markers and intracellular cytokines. Results : The investigated baseline parameters did not show significant differences between athlete and non- athlete young adults. In the elderly, levels of CD3 + 6B11 + NKT cells were lower, while ratios of CD4 + Th/CD8 + Tc cells were higher compared to the values of younger individuals. At the end of exercise programs, changes observed among 60- 75 year- olds were more pronounced compared to alterations developed in younger subjects. In elderly women, percentages of IgD+ naive B cells decreased, while levels of CD27 + switched- memory B cells increased. Furthermore, proportions of CD4 + IL- 4 + Th2 cells increased, while levels of CD8 + IFNgamma+ Tc cells and immunosuppressive CD4 + CD127- CD25 bright Treg cells decreased as the result of regular exercise. Conclusion : Differences observed after lightweight exercise programs reflect a presumably enhanced immunoreactivity and increased ability for immune responses, especially in older ages. The research was supported by the GINOP- 2.3.2- 15- 2016- 00062 project. The project is co- financed by the European Union from the European Regional Development Fund.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	Allergy. - 74 : S106 (2019), p. 421. -
További szerzők:	Szabó Krisztina (1987-) (Molekuláris biológus) Jámbor Ilona (1985-) (orvosi biotechológus) Mile Marianna (1977-) (gyógytornász) Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Balogh László (1976-) (kardiológus)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00062 GINOP
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001-es BibID:	BIBFORM007089
Első szerző:	Szamosi Szilvia (belgyógyász, reumatológus)
Cím:	Plasma homocysteine levels, the prevalence of methylenetetrahydrofolate reductase gene C677T polymorphism and macrovascular disorders in systemic sclerosis : risk factors for accelerated macrovascular damage? / Szamosi, S., Csiki, Z., Szomjak, E., Szolnoki, E., Szoke, G., Szekanecz, Z., Szegedi, G., Shoenfeld, Y., Szucs, G.
Dátum:	2009
ISSN:	1080-0549 (Print)
Megjegyzések:	The purpose of this study was to investigate plasma homocysteine (Hcy) levels in patients with systemic sclerosis (SSc) and to study the association between plasma Hcy, C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR), and the clinical manifestations in SSc. Associations of Hcy level, C677T MTHFR polymorphism, and macrovascular diseases were investigated in 152 patients with SSc and 58 controls. No significant differences in Hcy levels and MTHFR genotypes were found in SSc patients compared to controls or in SSc patients with limited cutaneous compared to diffuse disease. Significantly higher Hcy concentration was observed in patients with macroangiopathy/thromboembolic events compared to patients without such clinical manifestations (p < 0.05). There was significant correlation between age and macrovascular disorders, between Hcy level and the disease duration (r = 0.164; p < 0.05). Seventy-one percent of patients with macrovascular disorders had MTHFR polymorphism. In addition, 45% of patients with hyperhomocysteinemia had pulmonary hypertension. The presence of MTHFR C677T mutation influences the incidence of macrovascular abnormalities in SSc patients. Elevated Hcy levels may be associated with disease duration and the evolution of macrovascular disorders and pulmonary hypertension in SSc.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Female egyetemen (Magyarországon) készült közlemény Genetic Predisposition to Disease Homocysteine Humans Hypertrophy, Right Ventricular Male Methylenetetrahydrofolate Reductase (NADPH2) Middle Aged Polymorphism, Single Nucleotide Pulmonary Fibrosis Risk Factors Scleroderma, Systemic Thromboembolism Time Factors
Megjelenés:	Clinical Reviews in Allergy and Immunology. - 36 : 2-3 (2009), p. 145-9. -
További szerzők:	Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Szomják Edit (1961-) (belgyógyász) Szolnoki Erzsébet Szőke Gabriella Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Shoenfeld, Yehuda Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
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