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001-es BibID:BIBFORM078385
Első szerző:Abdel-Wahab, Nada
Cím:Induction of Secondary Metabolites from the Marine-Derived Fungus Aspergillus versicolor through Co-cultivation with Bacillus subtilis / Nada M. Abdel-Wahab, Sebastian Scharf, Ferhat C. Özkaya, Tibor Kurtán, Attila Mándi, Mostafa A. Fouad, Mohamed S. Kamel, Werner E. G. Müller, Rainer Kalscheuer, Wenhan Lin, Georgios Daletos, Weaam Ebrahim, Zhen Liu, Peter Proksch
Dátum:2019
ISSN:0032-0943
Megjegyzések:A new cyclic pentapeptide, cotteslosin C (1), a new aflaquinolone, 22-epi-aflaquinolone B (3), and two new anthraquinones (9 and 10), along with thirty known compounds (2, 4???8, 11???34) were isolated from a co-culture of the sponge-associated fungus Aspergillus versicolor with Bacillus subtilis. The new metabolites were only detected in the co-culture extract, but not when the fungus was grown under axenic conditions. Furthermore, the co-culture extract exhibited an enhanced accumulation of the known constituents versicolorin B (14), averufin (16), and sterigmatocyctin (19) by factors of 1.5, 2.0, and 4.7, respectively, compared to the axenic fungal culture. The structures of the isolated compounds were elucidated on the basis of 1D and 2D NMR spectra and mass spectrometry as well as by comparison with literature data. The absolute configuration of compounds 3, 9, and 10 was determined by ECD (electronic circular dichroism) analysis aided by TDDFT-ECD (time-dependent density functional theory electronic circular dichroism) calculations. Compounds 15, 18???21, and 26 exhibited strong to moderate cytotoxic activity against the mouse lymphoma cell line L5178Y, with IC50 values ranging from 2.0 to 21.2??M, while compounds 14, 16, 31, 32, and 33 displayed moderate inhibitory activities against several gram-positive bacteria, with MIC values ranging from 12.5 to 50??M.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
sponge-derived fungus
Aspergillus versicolor
cyclic pentapeptide
co-culture
ECD calculations
cytotoxicity
antibacterial activity
Megjelenés:Planta Medica. - 85 : 06 (2019), p. 503-512. -
További szerzők:Scharf, Sebastian Özkaya, Ferhat Kurtán Tibor (1973-) (vegyész, angol szakfordító) Mándi Attila (1981-) (vegyész, német szakfordító) Fouad, Mostafa A. Kamel, Mohamed S. Müller, Werner E. G. Kalscheuer, Rainer Lin, Wen Han Daletos, Georgios Ebrahim, Weaam Liu, Zhen Proksch, Peter
Pályázati támogatás:K120181
OTKA
PD121020
OTKA
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2.

001-es BibID:BIBFORM054937
Első szerző:Zhou, Zhen-Fang
Cím:Four Phragmalin Orthoesters from the Chinese Mangrove Xylocarpus granatum / Zhen-Fang Zhou, Ling-Yi Kong, Tibor Kurtán, Hai-Li Liu, Attila Mándi, Jia Li, Yu-Cheng Gu, Yue-Wei Guo
Dátum:2014
ISSN:0032-0943
Megjegyzések:Four new 8,9,30-phragmalin orthoesters (1-4), along with six related known compounds, namely xyloccensins O-S (5-9) and V (10), were isolated and characterized from the twigs and leaves of the Chinese mangrove Xylocarpus granatum. The structures of the new compounds were determined on the basis of extensive spectroscopic analysis and by comparison with those of related known compounds in the literature. The absolute configuration of xyloccensin Q (7) was revised as its enantiomer by X?ray diffraction analysis employing graphite monochromated Cu K?radiation (? = 1.54 178 A) with a Flack parameter of ?0.04 and was further secured by a time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculation. Consequently, the absolute configurations of xyloccensins O (5), P (6), R (8), S (9), and V (10) were all corrected as their corresponding enantiomers, respectively. Xyloccensin S (9) exhibited inhibitory activity against protein tyrosine phosphatase 1B, a potential drug target for the treatment of type II diabetes and obesity, with an IC50 value of 8.72 ?g/mL.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Meliaceae
Xylocarpus granatum
phragmalin orthoesters
configuration determination
biological activity
Megjelenés:Planta Medica. - 80 : 11 (2014), p. 949-954. -
További szerzők:Kong, Ling-Yi Kurtán Tibor (1973-) (vegyész, angol szakfordító) Liu, Hai-Li Mándi Attila (1981-) (vegyész, német szakfordító) Li, Jia Gu, Yu-Cheng Guo, Yue-Wei
Pályázati támogatás:K105871, K81701
OTKA
NIIFI 10038
Egyéb
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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