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001-es BibID:BIBFORM016873
Első szerző:Cai, You-Sheng
Cím:Palmarumycins BG1-BG7 and Preussomerin BG1 : Establishment of Their Absolute Configurations Using Theoretical Calculations of Electronic Circular Dichroism Spectra / You-Sheng Cai, Tibor Kurtán, Ze-Hong Miao, Attila Mándi, István Komáromi, Hai-Li Liu, Jian Ding, Yue-Wei Guo
Dátum:2011
Megjegyzések:Palmarumycins BG1-BG7 (1-7), seven new compounds related to palmarumycins, were isolated from the aerial parts of Bruguiera gymnorrhiza as well as a new preussomerin derivative BG1 (8). The structures of these compounds were determined mainly by the analysis of their NMR and MS data, and their relative configurations were assigned on the basis of their 3JH,H coupling constants. Compounds 4 and 7 have a sulfate group that is unprecedented amongmembers of spirodioxynaphthalene-type natural products. The absolute configurations of 1-8 were determined by TDDFT CD calculations of the solution conformers. Compound 5 displayed inhibitory activity against HL 60 and MCF-7 cell lines.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Organic Chemistry. - 76 : 6 (2011), p. 1821-1830. -
További szerzők:Kurtán Tibor (1973-) (vegyész, angol szakfordító) Miao, Ze-Hong Mándi Attila (1981-) (vegyész, német szakfordító) Komáromi István (1957-) (vegyész, molekuláris biológus, biokémikus) Liu, Hai-Li Ding, Jian Guo, Yue-Wei
Internet cím:DOI
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001-es BibID:BIBFORM061786
Cím:Bioactive isoquinolinequinone alkaloids from the South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp. / Ren-Yong Huang, Wen-Ting Chen, Tibor Kurtán, Attila Mándi, Jian Ding, Jia Li, Xu-Wen Li, Yue-Wei Guo
Dátum:2016
ISSN:1756-8919 1756-8927
Megjegyzések:Background: Nudibranchs are slug-like invertebrates, well known as rich sources of biologically active secondary metabolites with highly chemical diversity and complexity. The production of such interesting metabolites was possibly inflenced by their diet relationship with sponges such as Xestospongia. Results: Our continuous investigation of South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp. led to the isolation of two new and eight known metabolites (1-10). The absolute confiurations were determined by time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) method and by the comparison of ECD spectra. In bioassays, 1-4 and 7 showed strong NF-?B inhibitory activity, 4-6 exhibited considerable cytotoxicity against A549 and HL-60 tumor cell lines. Conclusion: Five unusual isoquinolinequinones (3, 7-10) were discovered from both two animals, further confimed their predator-prey relationship. Preliminary bioassay results and structure-activity relationship studies suggested that several isolated compounds were potential to be drug leads.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
epimer
NF-[kappa]B signaling pathway
TDDFT ECD
tetrahydroisoquinolinequinone
Megjelenés:Future Medicinal Chemistry. - 8 : 1 (2016), p. 17-27. -
További szerzők:Huang, Ren-Yong Chen, Wen-Ting Kurtán Tibor (1973-) (vegyész, angol szakfordító) Mándi Attila (1981-) (vegyész, német szakfordító) Ding, Jian Li, Jia Li, Xu-Wen Guo, Yue-Wei
Pályázati támogatás:K105871
OTKA
NIIFI 10038
Egyéb
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DOI
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