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001-es BibID:	BIBFORM041435
Első szerző:	Zhou, Yaming
Cím:	Alkaloids from the Sponge-Associated Fungus Aspergillus sp. / Yaming Zhou, Abdessamad Debbab, Attila Mándi, Victor Wray, Barbara Schulz, Werner E. G. Müller, Matthias Kassack, WenHan Lin, Tibor Kurtán, Peter Proksch, Amal H. Aly
Dátum:	2013
Megjegyzések:	Seven new alkaloids including tryptoquivaline K (1) and fumiquinazolines K-P (2-7), bearing a rare 1-aminocyclopropane-1-carboxylic acid residue, together with six known compounds (8-13), were isolated from the fungus Aspergillus sp. obtained from the Mediterranean sponge Tethya aurantium. The structures of the new compounds were determined by extensive analysis by 1D and 2D NMR spectroscopy and mass spectrometry. The absolute configurations of tryptoquivaline K (1) and fumiquinazolines K and L (2, 3) were determined by TDDFT ECD calculations of their solution conformers, and the configurational assignment of the related fumiquinazolines M-P (4-7) was achieved by comparison of their ECD spectra with those of compounds 2 and 3. All compounds were evaluated for their cytotoxic activity by the MTT method. Compound 8 exhibited pronounced cytotoxicity against the mouse lymphoma cell line (L5178Y) with an IC50 value of 3.6 ?M, but only moderate activity was observed against human ovarian cancer (A2780) and human Philadelphia chromosome-positive chronic myelogenous leukemia (K562) cell lines with IC50 values of 18.5 and 15.0 ?M, respectively.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Natural products Alkaloids Circular dichroism Configuration determination Structure elucidation Density functional calculations
Megjelenés:	European Journal of Organic Chemistry. - 2013 : 5 (2013), p. 894-906. -
További szerzők:	Debbab, Abdessamad Mándi Attila (1981-) (vegyész, német szakfordító) Wray, Victor Schulz, Barbara Müller, Werner E. G. Kassack, Matthias Lin, Wen Han Kurtán Tibor (1973-) (vegyész, angol szakfordító) Proksch, Peter Aly, Amal H.
Pályázati támogatás:	HURO/0901/274/2.2.2 Egyéb NIIFI 10038 Egyéb
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001-es BibID:	BIBFORM022515
Első szerző:	Zhou, Yaming
Cím:	New Austalides from the Sponge-Associated Fungus Aspergillus sp. / Yaming Zhou, Attila Mándi, Abdessamad Debbab, Victor Wray, Barbara Schulz, Werner E. G. Müller, WenHan Lin, Peter Proksch, Tibor Kurtán, Amal H. Aly
Dátum:	2011
ISSN:	1434-193X
Megjegyzések:	Chromatographic separation of a crude extract obtained from the fungus Aspergillus sp., isolated from the Mediterranean sponge Tethya aurantium, yielded five new meroterpenoid metabolites, austalides M?Q (1?5), together with nine known compounds (6?13). The structures of the new compounds were unambiguously elucidated on the basis of extensive 1D and 2D NMR methods and by mass spectral analysis. Furthermore, the absolute configurations of 1 and 4 were determined by time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculations, allowing he assignment of the absolute configuration of analogous compounds 2, 3, and 5. The calculations revealed that the conformation of the benzene-fused phthalide chromophore, which is sensitive to even minor changes in its proximity, is decisive for the ECD parameters, rendering a simple ECD comparison of related homochiral austalides difficult. All compounds were evaluated for their cytotoxic activity against murine cancer cell line L5178Y by using the MTT method. Compounds 8 and 11 exhibited moderate to pronounced cytotoxicity, with IC50 values of 39.4 and 0.2 ?M, respectively, whereas the remaining investigated compounds showed either weak or no activity in this assay.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Molekulatudomány Natural products Fused-ring systems Circular dichroism Density functional calculations Structure elucidation Cytotoxicity
Megjelenés:	European Journal Of Organic Chemistry. - 2011 : 30 (2011), p. 6009-6019. -
További szerzők:	Mándi Attila (1981-) (vegyész, német szakfordító) Debbab, Abdessamad Wray, Victor Schulz, Barbara Müller, Werner E. G. Lin, Wen Han Proksch, Peter Kurtán Tibor (1973-) (vegyész, angol szakfordító) Aly, Amal H.
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP O- és O,N heterociklusok szintézise és kiroptikai vizsgálata
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