CCL

Összesen 20 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM074136
Első szerző:Abdelwahab, Miada F.
Cím:Induced secondary metabolites from the endophytic fungus Aspergillus versicolor through bacterial co-culture and OSMAC approaches / Miada F. Abdelwahab, Tibor Kurtán, Attila Mándi, Werner E.G. Müller, Mostafa A. Fouad, Mohamed S. Kamel, Zhen Liu, Weaam Ebrahim, Georgios Daletos, Peter Proksch
Dátum:2018
ISSN:0040-4039
Megjegyzések:Two new cryptic 3,4-dihydronaphthalen-(2H)-1-one (1-tetralone) derivatives, aspvanicin A (1) and its epimer aspvanicin B (2), as well as several known cryptic metabolites (3-8), were obtained from the ethyl acetate extract of the co-culture of the endophytic fungus Aspergillus versicolor KU258497 with the bacterium Bacillus subtilis 168 trpC2 on solid rice medium. When A. versicolor was cultured axenically in liquid Wickerham medium supplemented with 3.5% DMSO, an additional three known secondary metabolites (9?11) were isolated that were lacking when the fungus was fermented on rice medium. The structures of the new compounds were elucidated using one- and two-dimensional NMR spectroscopy as well as HRESIMS. The relative and absolute configurations of 1 and 2 were determined by the combination of NMR and electronic circular dichroism (ECD) analysis aided by DFT conformational analysis and TDDFT-ECD calculations. The ECD calculations revealed that although the sign of the blue-shifted overlapping n-?* ECD transition follows the helicity rule of cyclic aryl ketones, the calculation of low-energy conformers and ECD spectra was necessary to determine the stereochemistry. All metabolites were assessed for their antibacterial and cytotoxic activities; one of the new diastereomers, compound 2, showed moderate cytotoxic activity against the mouse lymphoma cell line L5178Y.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Aspergillus versicolor
Tetralone derivatives
Absolute configuration
ECD calculations
Megjelenés:Tetrahedron Letters 59 : 27 (2018), p. 2647-2652. -
További szerzők:Kurtán Tibor (1973-) (vegyész, angol szakfordító) Mándi Attila (1981-) (vegyész, német szakfordító) Müller, Werner E. G. Fouad, Mostafa A. Kamel, Mohamed S. Liu, Zhen Ebrahim, Weaam Daletos, Georgios Proksch, Peter
Pályázati támogatás:NKFI K120181, PD121020
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM078385
Első szerző:Abdel-Wahab, Nada
Cím:Induction of Secondary Metabolites from the Marine-Derived Fungus Aspergillus versicolor through Co-cultivation with Bacillus subtilis / Nada M. Abdel-Wahab, Sebastian Scharf, Ferhat C. Özkaya, Tibor Kurtán, Attila Mándi, Mostafa A. Fouad, Mohamed S. Kamel, Werner E. G. Müller, Rainer Kalscheuer, Wenhan Lin, Georgios Daletos, Weaam Ebrahim, Zhen Liu, Peter Proksch
Dátum:2019
ISSN:0032-0943
Megjegyzések:A new cyclic pentapeptide, cotteslosin C (1), a new aflaquinolone, 22-epi-aflaquinolone B (3), and two new anthraquinones (9 and 10), along with thirty known compounds (2, 4???8, 11???34) were isolated from a co-culture of the sponge-associated fungus Aspergillus versicolor with Bacillus subtilis. The new metabolites were only detected in the co-culture extract, but not when the fungus was grown under axenic conditions. Furthermore, the co-culture extract exhibited an enhanced accumulation of the known constituents versicolorin B (14), averufin (16), and sterigmatocyctin (19) by factors of 1.5, 2.0, and 4.7, respectively, compared to the axenic fungal culture. The structures of the isolated compounds were elucidated on the basis of 1D and 2D NMR spectra and mass spectrometry as well as by comparison with literature data. The absolute configuration of compounds 3, 9, and 10 was determined by ECD (electronic circular dichroism) analysis aided by TDDFT-ECD (time-dependent density functional theory electronic circular dichroism) calculations. Compounds 15, 18???21, and 26 exhibited strong to moderate cytotoxic activity against the mouse lymphoma cell line L5178Y, with IC50 values ranging from 2.0 to 21.2??M, while compounds 14, 16, 31, 32, and 33 displayed moderate inhibitory activities against several gram-positive bacteria, with MIC values ranging from 12.5 to 50??M.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
sponge-derived fungus
Aspergillus versicolor
cyclic pentapeptide
co-culture
ECD calculations
cytotoxicity
antibacterial activity
Megjelenés:Planta Medica. - 85 : 06 (2019), p. 503-512. -
További szerzők:Scharf, Sebastian Özkaya, Ferhat Kurtán Tibor (1973-) (vegyész, angol szakfordító) Mándi Attila (1981-) (vegyész, német szakfordító) Fouad, Mostafa A. Kamel, Mohamed S. Müller, Werner E. G. Kalscheuer, Rainer Lin, Wen Han Daletos, Georgios Ebrahim, Weaam Liu, Zhen Proksch, Peter
Pályázati támogatás:K120181
OTKA
PD121020
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM100353
035-os BibID:(cikkazonosító)113124 (WoS)000765919400006 (Scopus)85124069495
Első szerző:Akone, Sergi Herve
Cím:Prenylated cyclohexene-type meroterpenoids and sulfur-containing xanthones produced by Pseudopestalotiopsis theae / Sergi Herve Akone, Hao Wang, Eitel Ngoh Misse Mouelle, Attila Mándi, Tibor Kurtán, Pierre Roger Koliye, Rudolf Hartmann, Sanil Bhatia, Jing Yang, Werner E. G. Müller, DaowanLai, Zhen Liu, Rainer Kalscheuer, Peter Proksch
Dátum:2022
ISSN:0031-9422
Megjegyzések:Chemical investigation of the fungal endophyte Pseudopestalotiopsis theae isolated from leaves of Caloncoba welwitschii, collected in Cameroon, resulted in two previously undescribed sulfur-containing xanthone derivatives sydoxanthones D and E, in addition to three previously undescribed monomeric diisoprenyl-cyclohexene-type meroterpenoids biscognienynes D-F and five known natural products. The structures of the undescribed compounds were unambiguously identified by their mass spectra and by extensive 1D and 2D NMR spectroscopic analysis. Mosher's reaction was performed to determine the absolute configuration of sydoxanthones D and E while TDDFT-ECD calculations were used to assign the configuration of biscognienyne D. Biscognienynes B and D showed significant cytotoxicity against the mouse lymphoma cell line L5178Y with IC50 values of 7.7 and 6.7 mu M and against the human leukemic cell lines HL60, and Hal-01 with IC50 values ranging from 4.3 to 12.1 mu M.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Pseudopestalotiopsis theae
Amphisphaeriaceae
Endophytic fungus
Sulfur-containing xanthone
Meroterpenoids
Cytotoxicity
Megjelenés:Phytochemistry. - 197 (2022), p. 1-8. -
További szerzők:Wang, Hao Mouelle, Eitel Ngoh Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Koliye, Pierre Roger Hartmann, Rudolf Bhatia, Sanil Yang, Jing Müller, Werner E. G. Lai, Daowan Kalscheuer, Rainer Proksch, Peter
Pályázati támogatás:GINOP-2.3.2-15-2016-00008
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM080474
Első szerző:Ariantari, Ni P.
Cím:Expanding the chemical diversity of an endophytic fungus Bulgaria inquinans, an ascomycete associated with mistletoe, through an OSMAC approach / Ni P. Ariantari, Georgios Daletos, Attila Mándi, Tibor Kurtán, Werner E. G. Müller, Wenhan Lin, Elena Ancheeva, Peter Proksch
Dátum:2019
ISSN:2046-2069 2046-2069
Megjegyzések:An endophytic fungus Bulgaria inquinans (isolate MSp3-1), isolated from mistletoe (Viscum album), was subjected to fermentation on solid Czapek medium. Chromatographic workup of the crude EtOAc extract yielded five new natural products (1?5). Subsequent application of the "One Strain, Many Compounds" (OSMAC) strategy on this strain by the addition of a mixture of salts (MgSO4, NaNO3 and NaCl) to solid Czapek medium induced the accumulation of nine additional new secondary metabolites (6?13, 16), with most of them (8, 10?12) not detectable in cultures lacking the salt mixture. The structures of the new compounds were established on the basis of the 1D/2D NMR and HRESIMS data. The TDDFT-ECD method was applied to determine the absolute configurations of the new compounds 1, 4 and 6 as well as of the previously reported bulgarialactone B (14), for which the absolute configuration was unknown so far. The modified Mosher's method was performed to assign the absolute configurations of 12 and 13. TDDFT-ECD analysis also allowed determining the absolute configuration of (+)-epicocconone, which had an enantiomeric absolute configuration in the tricyclic moiety compared to that of bulgarialactone B (14). All the isolated metabolites were evaluated for their cytotoxic activity. Compound 2 was found to possess strong cytotoxic activity against the murine lymphoma cell line L5178Y with an IC50 value of 1.8 mM, while the remaining metabolites were shown to be inactive.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:RSC Advances. - 9 : 43 (2019), p. 25119-25132. -
További szerzők:Daletos, Georgios Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Müller, Werner E. G. Lin, Wen Han Ancheeva, Elena Proksch, Peter
Pályázati támogatás:NKFI K120181
Egyéb
NKFI PD121020
Egyéb
GINOP-2.3.2-15-2016-00008
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM080011
035-os BibID:(WOS)000473827300003 (Scopus)85068241187
Első szerző:Ariantari, Ni P.
Cím:Indole Diterpenoids from an Endophytic Penicillium sp. / Ni P. Ariantari, Elena Ancheeva, Chenyin Wang, Attila Mándi, Tim-O. Knedel, Tibor Kurtán, Chaidir Chaidir, Werner E. G. Müller, Matthias U. Kassack, Christoph Janiak, Georgios Daletos, Peter Proksch
Dátum:2019
ISSN:0163-3864 1520-6025
Megjegyzések:A chemical investigation of the endophyte Penicillium sp. (strain ZO-R1-1), isolated from roots of the medicinal plant Zingiber of f icinale, yielded nine new indole diterpenoids (1-9), together with 13 known congeners (10-22). The structures of the new compounds were elucidated by 1D and 2D NMR analysis in combination with HRESIMS data. The absolute configuration of the new natural products 1, 3, and 7 was determined using the TDDFT-ECD approach and confirmed for 1 by single-crystal X-ray determination through anomalous dispersion. The isolated compounds were tested for cytotoxicity against L5178Y, A2780, J82, and HEK-293 cell lines. Compound 1 was the most active metabolite toward L5178Y cells, with an IC50 value of 3.6 mu M, and an IC50 against A2780 cells of 8.7 mu M. Interestingly, 1 features a new type of indole diterpenoid scaffold with a rare 6/5/6/6/6/6/5 heterocyclic system bearing an aromatic ring C, which is suggested to be important for the cytotoxic activity of this natural product against L5278Y and A2780 cells.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Natural Products. - 82 : 6 (2019), p. 1412-1423. -
További szerzők:Ancheeva, Elena Wang, Chen-Yin Mándi Attila (1981-) (vegyész, német szakfordító) Knedel, Tim-O. Kurtán Tibor (1973-) (vegyész, angol szakfordító) Chaidir, Chaidir Müller, Werner E. G. Kassack, Matthias Janiak, Christoph Daletos, Georgios Proksch, Peter
Pályázati támogatás:GINOP-2.3.2-15-2016-00008
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

6.

001-es BibID:BIBFORM072282
Első szerző:Ebada, Sherif Saeed
Cím:Cytotoxic secondary metabolites from the endophytic fungus Aspergillus versicolor KU258497 / Sherif S. Ebada, Mona El-Neketi, Weaam Ebrahim, Attila Mándi, Tibor Kurtán, Rainer Kalscheuer, Werner E.G. Müller, Peter Proksch
Dátum:2018
ISSN:1874-3900
Megjegyzések:Two new isocoumarin dimers (1 and 2) and one new dihydroquinolone derivative (3) were isolated from Aspergillus versicolor, an endophyte derived from leaves of the Egyptian water hyacinth Eichhornia crassipes (Pontederiaceae), together with ten other known metabolites. Chemical structures of the isolated metabolites were determined based on HRESIMS, extensive 1D and 2D NMR spectroscopy. The relative and absolute configurations of the new natural products were established by ROESY and electronic circular dichroism (ECD) spectroscopy, respectively. The axial chirality of the isocoumarin 7,7·-homodimers (1 and 2) was deduced by TDDFT-ECD calculations. All isolated compounds were assessed for their antimicrobial, antitubercular and cytotoxic activities. Several tested compounds revealed significant cytotoxic activity against mouse lymphoma L5178Y cell line with IC50 values ranging from < 0.36 to 16.3 ?M.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Aspergillus versicolor
Endophyte
Alkaloids
Antibacterial
Cytotoxicity
Tddft-ecd
Megjelenés:Phytochemistry Letters 24 (2018), p. 88-93. -
További szerzők:El-Neketi, Mona Ebrahim, Weaam Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Kalscheuer, Rainer Müller, Werner E. G. Proksch, Peter Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító)
Pályázati támogatás:NKFI K120181
Egyéb
NKFI PD121020
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

7.

001-es BibID:BIBFORM068584
Első szerző:Ebada, Sherif Saeed
Cím:Cytotoxic labdane diterpenes and bisflavonoid atropisomers from leaves of Araucaria bidwillii / Sherif S. Ebada, Aya N. Talaat, Rola M. Labib, Attila Mandi, Tibor Kurtan, Werner E.G. Müller, AbdelNasser Singab, Peter Proksch
Dátum:2017
ISSN:0040-4020
Megjegyzések:Chemical investigation of a methanolic extract of leaves from Araucaria bidwillii (Araucariaceae) from Egypt afforded four new labdane diterpenoidal metabolites (1?4) together with one known diterpene, 7-oxocallitrisic acid (5), two triterpenoidal metabolites, 2-O-acetyl-11-keto-boswellic acid (6) and bsitosterol-3-O-glucopyranoside (7), phloretic acid (8), and two methylated bisflavonoids, agathisflavone-4',7,7''-trimethyl ether (9) and cupressuflavone-4',7,7''-trimethyl ether (10). The new metabolites 1?4 were unambiguously identified by applying extensive 1D and 2D NMR spectroscopic studies as well as HRESIMS. The relative and absolute configurations of 1?4 were determined using ROESY and the modified Mosher's method, respectively. All isolated compounds were assessed for their antimicrobial, antitubercular and cytotoxic activities. Among the tested compounds, the new labdane diterpenes 1?4 revealed significant cytotoxic activity against mouse lymphoma L5178Y cell line with IC50 values ranging from 1.4 to 12.9 ?M, respectively.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Araucaria bidwillii
Labdane diterpene
Antibacterial
Cytotoxicity
TDDFT-ECD
Megjelenés:Tetrahedron. - 73 : 21 (2017), p. 3048-3055. -
További szerzők:Talaat, Aya N. Labib, Rola M. Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Müller, Werner E. G. Singab, Abdelnasser Proksch, Peter
Pályázati támogatás:GINOP-2.3.2-15-2016-00008
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

8.

001-es BibID:BIBFORM069592
Első szerző:Elnaggar, Mohamed S.
Cím:Hydroquinone derivatives from the marine-derived fungus Gliomastix sp. / Mohamed S. Elnaggar, Weaam Ebrahim, Attila Mandi, Tibor Kurtan, Werner E. G. Müller, Rainer Kalscheuer, Abdelnasser Singab, Wenhan Lin, Zhen Liu, Peter Proksch
Dátum:2017
ISSN:2046-2069
Megjegyzések:Eight new hydroquinone derivatives, gliomastins A-D (1-4), 9-O-methylgliomastin C (5), acremonin A 1-O-?-D-glucopyranoside (6), gliomastin E 1-O-?-D-glucopyranoside (7), and 6'-O-acetyl-isohomoarbutin (8), together with seven known analogues were isolated from the marine-derived fungus Gliomastix sp. Their structures were elucidated by extensive spectroscopic analysis including 1D and 2D NMR measurements aided by DFT NMR calculations as well as MS data. TDDFT-ECD and OR calculations were performed to determine the absolute configurations of 1 and the aglycones of 6 and 7. Compound 1 features a novel skeleton, biogenetically derived from a Diels?Alder reaction between derivatives of 11 and 13. Compound 2 represents a rare sulfur-containing alkaloid derived from the known hydroquinone 13. Compounds 1, 10 and 12 showed strong cytotoxicity against the L5178Y mouse lymphoma cell line with IC50 values of 1.8, 1.0 and 1.1 ?M, respectively. Compound 3 exhibited moderate antitubercular activity against Mycobacterium tuberculosis with a MIC value of 12.5 ?M.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:RSC Advances. - 7 : 49 (2017), p. 30640-30649. -
További szerzők:Ebrahim, Weaam Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Müller, Werner E. G. Kalscheuer, Rainer Singab, Abdelnasser Lin, Wen Han Liu, Zhen Proksch, Peter
Pályázati támogatás:NKFI K120181
Egyéb
NKFI PD121020
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

9.

001-es BibID:BIBFORM063403
Első szerző:Elnaggar, Mohamed S.
Cím:Xanthones and sesquiterpene derivatives from a marine-derived fungus Scopulariopsis sp. / Mohamed S. Elnaggar, Sherif S. Ebada, Mohamed L. Ashour, Weaam Ebrahim, Werner E.G. Müller, Attila Mándi, Tibor Kurtán, Abdelnasser Singab, Wenhan Lin, Zhen Liu, Peter Proksch
Dátum:2016
ISSN:0040-4020
Megjegyzések:Two new xanthone derivatives, 12-dimethoxypinselin (1) and 12-O-acetyl-AGI-B4 (2), as well as two new phenolic bisabolane-type sesquiterpenes, 11,12-dihydroxysydonic acid (15) and 1-hydroxyboivinianic acid (16), together with one new alkaloid, scopulamide (21) and one new alpha-pyrone derivative, scopupyrone (26), in addition to twenty-three known compounds (3-14, 17-20, 22-25, 27-29) were isolated from solid rice cultures of the marine-derived fungus Scopulariopsis sp. obtained from the Red Sea hard coral Stylophora sp. All compounds were unambiguously identified through extensive NMR spectroscopic analyses, and by comparison with the literature. Marfey's reaction was performed to determine the absolute configuration of scopulamide (21) and TDDFT-ECD calculations were used to assign the configuration of AGI-B4 (3) and scopupyrone (26). All isolated compounds were evaluated for their cytotoxicity against L5178Y mouse lymphoma cells and the structure-activity relationships were discussed.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Scopulariopsis sp.
Xanthone
Sesquiterpene
Structural elucidation
Cytotoxicity
Megjelenés:Tetrahedron. - 72 : 19 (2016), p. 2411-2419. -
További szerzők:Ebada, Sherif Saeed Ashour, Mohamed L. Ebrahim, Weaam Müller, Werner E. G. Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Singab, Abdelnasser Lin, Wen Han Liu, Zhen Proksch, Peter
Pályázati támogatás:K105871
OTKA
NIIFI 10038
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

10.

001-es BibID:BIBFORM085940
035-os BibID:(WOS)000483435000012 (Scopus)85071712121
Első szerző:Frank, Marian
Cím:Brominated Azaphilones from the Sponge-Associated Fungus Penicillium canescens Strain 4.14.6a / Marian Frank, Rudolf Hartmann, Malte Plenker, Attila Mándi, Tibor Kurtán, Ferhat Can Özkaya, Werner E. G. Müller, Matthias U. Kassack, Alexandra Hamacher, Wenhan Lin, Zhen Liu, Peter Proksch
Dátum:2019
ISSN:0163-3864 1520-6025
Megjegyzések:The fungus Penicillium canescens was isolated from the inner tissue of the Mediterranian sponge Agelas oroides. Fermentation of the fungus on solid rice medium yielded one new chlorinated diphenyl ether (1) and 13 known compounds (2-14). Addition of 5% NaBr to the rice medium increased the amounts of 4-6, while lowering the amounts of 8, 12, and 14. Furthermore, it induced the accumulation of 17 and two new brominated azaphilones, bromophilones A and B (15 and 16). Compounds 15 and 16 are the first example of azaphilones with the connection of a benzene moiety and the pyranoquinone core through a methylene group. The structures of the new compounds were elucidated based on the 1D and 2D NMR spectra as well as on HRESIMS data. The absolute configuration of the condensed bicyclic moiety of 15 and 16 was determined by sTDA ECD calculations. Compound 16 exhibited moderate cytotoxicity against the mouse lymphoma cell line L5178Y (IC50 8.9 mu M), as well as against the human ovarian cancer cell line A2780 (IC50 2.7 mu M), whereas the stereoisomer 15 was considerably less active.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Natural Products. - 82 : 8 (2019), p. 2159-2166. -
További szerzők:Hartmann, Rudolf Plenker, Malte Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Özkaya, Ferhat Müller, Werner E. G. Kassack, Matthias Hamacher, Alexandra Lin, Wen Han Liu, Zhen Proksch, Peter
Pályázati támogatás:K120181
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

11.

001-es BibID:BIBFORM057872
Első szerző:Hammerschmidt, Lena
Cím:Two new metabolites from the endophytic fungus Xylaria sp. isolated from the medicinal plant Curcuma xanthorrhiza / Lena Hammerschmidt, Antonius Ola, Werner E. G. Müller, WenHan Lin, Attila Mándi, Tibor Kurtán, Peter Proksch, Amal H. Aly
Dátum:2015
ISSN:0040-4039
Megjegyzések:The endophytic fungus Xylaria sp. was isolated from healthy leaves of Curcuma xanthorrhiza, collected on the island of Timor, Indonesia. Two new compounds (1 and 2), together with the known resacetophenone (3), were isolated and their structures were elucidated on the basis of comprehensive NMR and mass spectral analyses. The enantiomers of rac-1 were separated by chiral HPLC and their HPLC-ECD spectra were recorded to determine the absolute configuration on the basis of TDDFT-ECD calculations. The (3R,3aR, 9aR) absolute configuration of the optically active 2 was established by comparing the experimental solution ECD spectrum with the TDDFT ones computed for the gas phase and solution (PCM solvent model) conformers.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Circular dichroism
Curcuma xanthorrhiza
Endophytic fungus
Xylaria sp.
Megjelenés:Tetrahedron Letters. - 56 : 10 (2015), p. 1193-1197. -
További szerzők:Ola, Antonius R. B. Müller, Werner E. G. Lin, Wen Han Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Proksch, Peter Aly, Amal H.
Pályázati támogatás:K105871
OTKA
NIIFI 10038
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

12.

001-es BibID:BIBFORM088413
035-os BibID:(cikkazonosító)104698
Első szerző:Harwoko, Harwoko
Cím:Azacoccones F-H, new flavipin-derived alkaloids from an endophytic fungus Epicoccum nigrum MK214079 / Harwoko Harwoko, Jungho Lee, Rudolf Hartmann, Attila Mándi, Tibor Kurtán, Werner E.G.Müller, Michael Feldbrügge, Rainer Kalscheuer, Elena Ancheeva, Georgios Daletos, Marian Frank, Zhe Liu, Peter Proksch
Dátum:2020
ISSN:0367-326X
Megjegyzések:Three new flavipin-derived alkaloids, azacoccones F-H (1-3), along with six known compounds (4-9) were isolated from the endophytic fungus Epicoccum nigrum MK214079 associated with leaves of Salix sp. The structures of the new compounds were established by analysis of their 1D/2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HRESIMS) data. The absolute configuration of azacoccones F-H (1?3) was determined by comparison of experimental electronic circular dichroism (ECD) data with reported ones and biogenetic considerations. Epicocconigrone A (4), epipyrone A (5), and epicoccolide B (6) exhibited moderate antibacterial activity against Staphylococcus aureus ATCC 29213 with minimal inhibitory concentration (MIC) values ranging from 25 to 50 ?M. Furthermore, epipyrone A (5) and epicoccamide A (7) displayed mild antifungal activity against Ustilago maydis AB33 with MIC values of 1.6 and 1.8 mM, respectively. Epicorazine A (8) showed pronounced cytotoxicity against the L5178Y mouse lymphoma cell line with an IC50 value of 1.3 ?M.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Epicoccum nigrum
Flavipin
Alkaloids
Antimicrobial
Cytotoxicity
Megjelenés:Fitoterapia. - 146 (2020), p. 1-6. -
További szerzők:Lee, Jungho Hartmann, Rudolf Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Müller, Werner E. G. Feldbrügge, Michael Kalscheuer, Rainer Ancheeva, Elena Daletos, Georgios Frank, Marian Liu, Zhen Proksch, Peter
Pályázati támogatás:NKFI K120181
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1 2 
Corvina könyvtári katalógus v8.2.27 © 2023 Monguz kft. Minden jog fenntartva.