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001-es BibID:BIBFORM064483
035-os BibID:(WOS)000378758200016 (Scopus)84976433453
Első szerző:Zhang, Haibo
Cím:Alpha-Pyrones with Diverse Hydroxy Substitutions from Three Marine-Derived Nocardiopsis Strains / Haibo Zhang, Kumar Saurav, Ziquan Yu, Attila Mándi, Tibor Kurtán, Jie Li, Xinpeng Tian, Qingbo Zhang, Wenjun Zhang, Changsheng Zhang
Dátum:2016
ISSN:0163-3864 1520-6025
Megjegyzések:Eight new alpha-pyrones 1-8 and three known alpha-pyrones 9-11 were isolated from three marine-derived Nocardiopsis strains SCSIO 10419, SCSIO 04583, and SCSIO KS107. The structures of compounds 1-8 were elucidated by comprehensive spectral analyses. The absolute configurations of 4-deoxyphomapyrone C (1), 4-deoxy-11-hydroxyphomapyrone C (3), 4-deoxy-7R-hydroxyphomapyrone C (5), and phomapyrone C (11) were determined by TDDFT-ECD calculations for the solution conformers, which revealed that the conformation of the side chain was decisive for the sign of the characteristic high-wavelength ECD transition. (-)-4-Deoxy-8-hydroxyphomapyrone C (4) was isolated from SCSIO 10419 and was deduced as a diastereomeric mixture containing (8S)- and (8R)-4-deoxy-8-hydroxyphomapyrone C in a ratio of 2.6:1 (8R:8S), by chiral phase HPLC analysis and Mosher's ester analysis. Interestingly, 7-hydroxymucidone (9) was isolated from both SCSIO 04583 and SCSIO KS107, as an enantiomeric mixture containing (7S)-hydroxymucidone (major in 9 from SCSIO 04583) and (7R)-hydroxymucidone (major in 9 from SCSIO KS107). alpha-Pyrones 3-5 were identified as three isomers of phomapyrone C (II) with diverse hydroxy substitutions. alpha-Pyrones 10-hydroxymucidone (6), 4-hydroxymucidone (8), and 9, differed in the position of the hydroxy group. Several alpha-pyrones exhibited moderate growth inhibitory activity against Micrococcus luteus and Bacillus subtilis.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Natural Products. - 79 : 6 (2016), p. 1610-1618. -
További szerzők:Saurav, Kumar Yu, Ziquan Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Li, Jie Tian, Xinpeng Zhang, Qingbo Zhang, Wenjun Zhang, Changsheng
Pályázati támogatás:K105871
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NIIFI 10038
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