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001-es BibID:	BIBFORM069609
Első szerző:	Ancheeva, Elena
Cím:	Expanding the Metabolic Profile of the Fungus Chaetomium sp. through Co-culture with Autoclaved Pseudomonas aeruginosa / Elena Ancheeva, Lisa Küppers, Sergi Herve Akone, Weaam Ebrahim, Zhen Liu, Attila Mándi, Tibor Kurtán, Wenhan Lin, Raha Orfali, Nidja Rehberg, Rainer Kalscheuer, Georgios Daletos, Peter Proksch
Dátum:	2017
ISSN:	1434-193X 1099-0690
Megjegyzések:	The mixed fermentation of the fungal endophyte Chaetomium sp. with an autoclaved culture of the bacterium Pseudomonas aeruginosa on solid rice medium led to an up to 33-fold increase in the accumulation of constitutively present fungal secondary metabolites (3-10), which included four new butenolide derivatives (3-5 and 7). In addition, two further shikimic acid analogues (1 and 2) were obtained from mixed cultures that were neither detected in axenic cultures of the fungus nor of the bacterium. Chaetoisochorismin (1 ) possesses an unusual (3-methoxycarbonylphenyl)pyruvate core structure. The structures of the new compounds were unequivocally elucidated by HRESIMS, one- and two-dimensional NMR analysis as well as by comparison with literature data. The absolute configurations of the structures of the new derivatives 1 and 2 were established by ECD calculations as well as by the modified Mosher's method. Compounds 1-3 and 5-7 were subjected to antimicrobial and cytotoxicity assays but were shown to be inactive.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Chaetomium sp. Autoclaved Pseudomonas aeruginosa Shikimic acid derivatives Structure elucidation TDDFT-ECD calculations Biosynthesis
Megjelenés:	European Journal of Organic Chemistry 22 (2017), p. 3256-3264. -
További szerzők:	Küppers, Lisa Akone, Sergi Herve Ebrahim, Weaam Liu, Zhen Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Lin, Wen Han Orfali, Raha Rehberg, Nidja Kalscheuer, Rainer Daletos, Georgios Proksch, Peter
Pályázati támogatás:	NKFI K120181 Egyéb NKFI PD121020 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM067227
035-os BibID:	(WOS)000393089600023 (Scopus)85011074048
Első szerző:	Muharini, Rini
Cím:	Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa / Rini Muharini, Adriana Díaz, Weaam Ebrahim, Attila Mándi, Tibor Kurtán, Nidja Rehberg, Rainer Kalscheuer, Rudolf Hartmann, Raha S. Orfali, Wenhan Lin, Zhen Liu, Peter Proksch
Dátum:	2017
ISSN:	0163-3864
Megjegyzések:	Fourteen new natural products, namely, 2-[(Z)-styryl]-5-geranylresorcin-1-carboxylic acid (1), amorfrutin D (2), 4-O-demethylamorfrutin D (3), 8-geranyl-3,5,7-trihydroxyflavanone (4), 8-geranyl-5,7,3'-trihydroxy-4'-methoxyisoflavone (5), 6-geranyl-5,7,3'-trihydroxy-4'-methoxyisoflavone (6), 8-geranyl-7,3'-dihydroxy-4'-methoxyisoflavone (7), 3-O-demethyldalbinol (8), 6a,12a-dehydro-3-O-demethylamorphigenin (9), (6aR.,12aR,5'R)-amorphigenin (10), amorphispironones B and C (11 and 12), resokaempferol 3-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyrano side-7-O-alpha-L-rhamnopyranoside (13), and daidzein 7-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranoside (14), together with 40 known compounds, were isolated from the fruits of Amorpha fruticosa. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopic analysis as well as from the mass spectrometry data. ECD calculations were performed to determine the absolute configurations of 11 and 15. Compounds 1, 4-6, and 16-23 showed potent to moderate antibacterial activities against several Gram-positive bacteria with MIC values ranging from 3.1 to 100 mu M. In addition, compounds 11 and 24-33 were significantly cytotoxic against the L5178Y mouse lymphoma cell line and exhibited IC50 values from 0.2 to 10.2 mu M.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of Natural Products. - 80 : 1 (2017), p. 169-180. -
További szerzők:	Díaz, Adriana Ebrahim, Weaam Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Rehberg, Nidja Kalscheuer, Rainer Hartmann, Rudolf Orfali, Raha Lin, Wen Han Liu, Zhen Proksch, Peter
Pályázati támogatás:	NIIFI 10038 Egyéb GINOP-2.3.2-15-2016-00008 GINOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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