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001-es BibID:	BIBFORM095510
Első szerző:	Okoth, Dorothy A.
Cím:	Structure and biosynthesis of sorangipyranone - a new γ-dihydropyrone from the myxobacterial strain MSr12020 / Dorothy A. Okoth, Joachim J. Hug, Attila Mándi, Tibor Kurtán, Ronald Garcia, Rolf Müller
Dátum:	2021
ISSN:	1367-5435
Megjegyzések:	Sorangipyranone was isolated as a novel natural product featuring a unique 2,3-dihydro-?-4H-pyrone scaffold from cultures of the myxobacterial strain MSr12020. We report here the full structure elucidation of sorangipyranone by spectroscopic techniques including 2D NMR and high-resolution mass spectrometry together with the analysis of the biosynthetic pathway. Determination of the absolute configuration was performed by time-dependent density functional theory?electronic circular dichroism calculations and determination of the applicability of the Snatzke's helicity rule, to correlate the high-wavelength n??* electronic circular dichroism (ECD) transition and the absolute configuration of the 2,3-dihydro-4H-?-pyrone, was done by the analysis of low-energy conformers and the Kohn-Sham orbitals. Sorangipyranone outlines a new class of a γ-dihydropyrone-containing natural product comprised of malonyl-CoA-derived building blocks and features a unique polyketide scaffold. In silico analysis of the genome sequence of the myxobacterial strain MSr12020 complemented with feeding experiments employing stable isotope-labeled precursors allowed the identification and annotation of a candidate biosynthetic gene cluster that encodes a modular polyketide synthase assembly line. A model for the biosynthetic pathway leading to the formation of the γ-dihydropyrone one scaffold is presented in this study.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Myxobacteria Natural products γ-dihydropyrone
Megjelenés:	Journal of Industrial Microbiology & Biotechnology. - 48 : 3-4 (2021), p. 1-11. -
További szerzők:	Hug, Joachim J. Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Garcia, Ronald Müller, Rolf
Pályázati támogatás:	NKFI K120181 Egyéb NKFI FK134653 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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