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001-es BibID:	BIBFORM117429
035-os BibID:	(WoS)001096765100001 (Scopus)85176563372
Első szerző:	Sum, Winnie Chemutai
Cím:	Neurite Outgrowth-Inducing Drimane-Type Sesquiterpenoids Isolated from Cultures of the Polypore Abundisporus violaceus MUCL 56355 / Winnie Chemutai Sum, Sherif S. Ebada, Marco Kirchenwitz, Lucy Wanga, Cony Decock, Theresia E. B. Stradal, Josphat Clement Matasyoh, Attila Mándi, Tibor Kurtán, Marc Stadler
Dátum:	2023
ISSN:	0163-3864 1520-6025
Megjegyzések:	Abundisporin A (1), together with seven previously undescribed drimane sesquiterpenes named abundisporins B-H (2-8), were isolated from a polypore, Abundisporus violaceus MUCL 56355 (Polyporaceae), collected in Kenya. Chemical structures of the isolated compounds were elucidated based on exhaustive 1D and 2D NMR spectroscopic measurements and supported by HRESIMS data. The absolute configurations of the isolated compounds were determined by using Mosher's method for 1-4 and TDDFT-ECD calculations for 4 and 5-8. None of the isolated compounds exhibited significant activities in either antimicrobial or cytotoxicity assays. Notably, all of the tested compounds demonstrated neurotrophic effects, with 1 and 6 significantly increasing outgrowth of neurites when treated with 5 ng/mL NGF.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Absolute configuration Carbene compounds Carbon Circular dichroism spectroscopy Molecular structure
Megjelenés:	Journal of Natural Products. - 86 : 11 (2023), p. 2457-2467. -
További szerzők:	Ebada, Sherif Saeed Kirchenwitz, Marco Wanga, Lucy Decock, Cony Stradal, Theresia E. B. Matasyoh, Josphat Clement Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Stadler, Marc
Pályázati támogatás:	K138672 OTKA FK134653 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM120591
035-os BibID:	(WoS)001189155600001 (Scopus)85188428368
Első szerző:	Wennrich, Jan-Peer
Cím:	Omnipolyphilins A and B: Chlorinated Cyclotetrapeptides and Naphtho-α-pyranones from the Plant Nematode-Derived Fungus Polyphilus sieberi / Jan-Peer Wennrich, Sherif S. Ebada, Ellen Sepanian, Caren Holzenkamp, Syeda J. Khalid, Hedda Schrey, Wolfgang Maier, Attila Mándi, Tibor Kurtán, Samad Ashrafi, and Marc Stadler
Dátum:	2024
ISSN:	0021-8561
Megjegyzések:	Chemical exploration for two isolates of the recently described ascomycete species Polyphilussieberi, derived from the eggs of the plant parasitic nematode Heterodera filipjevi, afforded the identification of many compounds that belong to various metabolite families: two previously undescribed chlorinated cyclotetrapeptides, omnipolyphilins A (1) and B (2), one new pyranonaphthoquinone, ventiloquinone P (3), a 6,6 '-binaphto-alpha-pyranone dimer, talaroderxine D (4) in addition to nine known metabolites (5-13) were isolated from this biocontrol candidate. All isolated compounds were characterized by comprehensive 1D, 2D NMR, and HR-ESI-MS analyses. The absolute configurations of the cyclotetrapeptides were determined by a combination of advanced Marfey's method, ROE correlation aided by conformational analysis, and TDDFT-ECD calculations, while ECD calculations, Mosher's method, and experimental ECD spectra were used for ventiloquinone P (3) and talaroderxine D (4). Among the isolated compounds, talaroderxine D (4) showed potent antimicrobial activities against Bacillus subtilis and Staphylococcus aureus with MIC values of 2.1 and 8.3 mu g mL(-1), respectively. Additionally, promising inhibitory effects on talaroderxine D (4) against the formation of S. aureus biofilms were observed up to a concentration of 0.25 mu g mL(-1). Moreover, ophiocordylongiiside A (10) showed activity against the free-living nematode Caenorhabditis elegans.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk helotiales cyclotetrapeptides naphthopyranones antimicrobial nematicidal
Megjelenés:	Journal of Agricultural and Food Chemistry. - 72 : 13 (2024), p. 6998-7009. -
További szerzők:	Ebada, Sherif Saeed Sepanian, Ellen Holzenkamp, Caren Khalid, Syeda J. Schrey, Hedda Maier, Wolfgang Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Ashrafi, Samad Stadler, Marc
Pályázati támogatás:	K138672 OTKA FK134653 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: