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001-es BibID:	BIBFORM114612
035-os BibID:	(WoS)001026992900001 (Scopus)85165695315
Első szerző:	Wang, Lin
Cím:	Asperphenalenones Isolated from the Biocontrol Agent Clonostachys rosea and Their Antimicrobial Activities / Lin Wang, Anna-Lene Kiffe-Delf, Philipp Niklas Ostermann, Viktor Emanuel Simons, Di He, Ying Gao, Lasse van Geelen, Hao-Fu Dai, You-Xing Zhao, Heiner Schaal, Attila Mándi, Sándor Balázs Király, Tibor Kurtán, Zhen Liu, and Rainer Kalscheuer
Dátum:	2023
ISSN:	0021-8561
Megjegyzések:	Clonostachys rosea is a fungus widely distributed on Earth and has a high capacity to adapt to complex environments in soil, plants, or sea. It is an endophyte that can be used as a potential biocontrol agent to protect plants from pathogenic fungi, nematodes, and insects. However, the spectrum of secondary metabolites produced by C. rosea has only scarcely been studied. In the present study, eight new phenalenones, asperphenalenones F-M (1-8), together with two known derivatives, asperphenalenones E and B (9 and 10), were isolated from the axenic rice culture of this fungus. The structures of the new compounds were elucidated by nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, electronic circular dichroism, and gas chromatography-mass spectrometry analyses. Asperphenalenones J-M (5-8) are unusual phenalenone adducts that are conjugated to diterpenoid glycosides. Asperphenalenones F and H showed moderate antibacterial activity against methicillin-resistant Staphylococcus aureus, with minimal inhibitory concentrations of 12.5 and 25 ?M, respectively. Asperphenalenone B exhibited low antiviral activity against the human immunodeficiency virus replication. Furthermore, asperphenalenones F and H exhibited low cytotoxicity against Jurkat cells, while all other compounds were devoid of cytotoxicity.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Clonostachys rosea asperphenalenones antibacterial activity methicillin-resistant Staphylococcus aureus (MRSA) anti-HIV activity
Megjelenés:	Journal of Agricultural and Food Chemistry. - 71 : 29 (2023), p. 11056-11068. -
További szerzők:	Kiffe-Delf, Anna-Lene Ostermann, Philipp Niklas Simons, Viktor Emanuel He, Di Gao, Ying van Geelen, Lasse Dai, Haofu Zhao, You-Xing Schaal, Heiner Mándi Attila (1981-) (vegyész, német szakfordító) Király Sándor Balázs (1991-) (vegyész) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Liu, Zhen Kalscheuer, Rainer
Pályázati támogatás:	K138672 OTKA FK134653 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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