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001-es BibID:	BIBFORM006182
Első szerző:	Szekanecz Éva (onkológus szakorvos)
Cím:	Incidence of lymphoma in systemic sclerosis : a retrospective analysis of 218 Hungarian patients with systemic sclerosis / Éva Szekanecz, Szilvia Szamosi, Lajos Gergely, Péter Keszthelyi, Zoltán Szekanecz, Gabriella Szűcs
Dátum:	2008
Megjegyzések:	Recent results suggest that B cells may have multiple pathogenic roles in systemic sclerosis (SSc) and there may be increased incidence of B cell lymphomas in SSc. Here, we assessed the prevalence of lymphomas in a large SSc cohort. We analyzed data of 218 Hungarian patients undergoing follow-ups in our institutions between 1995 and 2007. During this follow-up period, there were three SSc patients, who eventually developed B cell lymphoma. The first case is a woman with diffuse cutaneous form of SSc (dcSSc) including pulmonary, cardiac, gastrointestinal, and renal manifestations and anti-topoisomerase I antibody positivity. B cell chronic lymphocytic leukemia (B-CLL) with Zap70 expression (Rai I stage) developed 2 years after the onset of SSc. The second case is a woman with dcSSc presenting with pulmonary, cardiac, and gastroesophageal manifestations. Twenty-one months after disease onset, a chronic small lymphocytic B cell non-Hodgkin's lymphoma was diagnosed from retroperitoneal lymph nodes. Our third case is a woman with dcSSc and no internal organ manifestations. She also developed Zap70-positive B-CLL, stage Rai I 9 months after the onset of SSc. Thus, there were three cases of B cell lymphoma among our 218 SSc patients (1.38%). The association of scleroderma and non-Hodgkin's lymphoma may be a rather uncommon feature; however, the incidence of lymphoma among Hungarian SSc patients may be 1.9-2.5 times higher than that in the general population. In our three patients, B cell lymphoma developed within 2 years after the onset of SSc. Altered B cell function implicated in the pathogenesis of SSc may lead to the development of lymphoid malignancies.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Clinical Rheumatology. - 27 : 9 (2008), p. 1163-1166. -
További szerzők:	Szamosi Szilvia (1975-) (belgyógyász, reumatológus) Gergely Lajos (1965-) (belgyógyász, haematológus) Keszthelyi Péter Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
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001-es BibID:	BIBFORM029444
Első szerző:	Váróczy László (belgyógyász, haematológus)
Cím:	Malignant lymphomas and autoimmunity - a single center experience from Hungary / László Váróczy, Edit Páyer, Zsuzsanna Kádár, Lajos Gergely, Zsófia Miltényi, Ferenc Magyari, Péter Szodoray, Árpád Illés
Dátum:	2012
ISSN:	0770-3198
Megjegyzések:	Autoimmune diseases and malignant lymphomas have numerous similarities in their etiology and pathogenesis. Patients with autoimmune disorders have increased risk to develop non-Hodgkin's lymphomas, yet little is known about the occurrence of autoimmune features within lymphoma patients. Our aim was to examine the prevalence of autoimmune diseases among patients with non-Hodgkin's (NHL) and Hodgkin's lymphoma (HL). We reviewed 352 patients' charts with malignant lymphomas to assess the rate of associated autoimmune diseases. Of 231 NHL patients, 30 (12.9%) had autoimmune disorders, while there were 11 patients who suffered from more than one disease entity. It was Sjögren's syndrome that occurred in the largest number (eight cases), other frequent entities were undifferentiated connective tissue disease (seven), thyroiditis (six), rheumatoid arthritis (four), and systemic vasculitis (four). The female/male ratio was significantly different between patients with or without autoimmune diseases, while no other clinical features differed significantly between the two groups. Ten patients (33.3%) were initially diagnosed with lymphoma, 13 (43.3%) of them had already been diagnosed with autoimmune disease at the time of lymphoma occurrence. Six patients (20%) with previously diagnosed immunological disorder developed new autoimmune condition after the treatment of lymphoma. Lymphoma and autoimmune disease occurred simultaneously in one patient. Among the 121 HL patients, 14 (11.5%) had associated autoimmune disease. Ten patients developed thyroiditis after the lymphoma treatment, two had immune thrombocytopenia, and one had autoimmune hemolytic anemia. One female patient was diagnosed with systemic sclerosis 10 years before the onset of HL. Our results highlight that an increased risk for the development of autoimmune diseases should be considered in patients both with NHL and HL.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban autoimmune disease Hodgkin's, lymphoma non-Hodgkin's egyetemen (Magyarországon) készült közlemény
Megjelenés:	Clinical Rheumatology. - 31 : 2 (2012), p. 219-224. -
További szerzők:	Páyer Edit (1982-) Kádár Zsuzsanna Gergely Lajos (1965-) (belgyógyász, haematológus) Miltényi Zsófia (1975-) (belgyógyász, haematológus) Magyari Ferenc (1985-) (belgyógyász, hematológus) Szodoray Péter (1973-) (belgyógyász, orvos) Illés Árpád (1959-) (belgyógyász, haematológus, onkológus)
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