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001-es BibID:BIBFORM016328
Első szerző:Maródi László (gyermekgyógyász infektológus, immunológus)
Cím:Augmentation of Human Macrophage Candidacidal Capacity by Recombinant Human Myeloperoxidase and Granulocyte- Macrophage Colony-Stimulating Factor / Maródi László, Tournay Christophe, Káposzta Rita, Richard B. Johnston J.R., Nicole Moguilevsky
Dátum:1998
Megjegyzések:Phagocyte myeloperoxidase (MPO) is believed to be particularly important in defense against candida infection. We reported earlier that monocytes, rich in MPO, killed Candida albicans at a significantly higher rate and extent than did monocyte-derived macrophages, known to lack MPO, and that C. albicans is less resistant to MPO-dependent oxidants than less pathogenic Candida species. We hypothesized, therefore, that the capacity of macrophages to kill C. albicans might be improved in the presence of MPO. In this study, we evaluated the ability of recombinant human MPO (rhMPO) to augment the killing of C. albicans by resident macrophages and macrophages activated by recombinant human granulocyte-macrophage colony-stimulating factor. Addition of rhMPO (concentration range, 0.8 to 6.4 U/ml) to suspensions of resident and activated macrophages and opsonized C. albicans resulted in concentration-dependent and significant increases in candida killing. This enhancement was particularly pronounced with activated macrophages, whether C. albicans was opsonized or unopsonized and ingested through the macrophage mannose receptor. rhMPO did not affect the killing of C. albicans by monocytes, nor did it affect phagocytosis of opsonized or unopsonized C. albicans. These results indicate that exogenous rhMPO can augment the candidacidal capacity of both resident and activated macrophages, with a more profound effect on activated cells. We suggest that rhMPO may be effective in the treatment of invasive candidiasis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Infection and Immunity. - 66 : 6 (1998), p. 2750-2754. -
További szerzők:Christophe, Tournay Káposzta Rita (1968-) (csecsemő- és gyermekgyógyász) Johnston, Richard B. jr. Moguilevsky, Nicole
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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