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1.

001-es BibID:BIBFORM033447
Első szerző:Bajkó Zoltán (neurológus)
Cím:Anxiety, depression and autonomic nervous system dysfunction in hypertension / Bajkó Zoltán, Szekeres Csilla-Cecília, Kovács Katalin Réka, Csapó Krisztina, Molnár Sándor, Soltész Pál, Nyitrai Erika, Magyar Mária Tünde, Oláh László, Bereczki Dániel, Csiba László
Dátum:2012
ISSN:0022-510X
Megjegyzések:OBJECTIVES: This study examined the relationship between autonomic nervous system dysfunction, anxiety and depression in untreated hypertension. PATIENTS AND METHODS: 86 newly diagnosed hypertensive patients and 98 healthy volunteers were included in the study. The psychological parameters were assessed with Spielberger State-Trait Anxiety Inventory and Beck Depression Inventory by a skilled psychologist. Autonomic parameters were examined during tilt table examination (10min lying position, 10min passive tilt). Heart rate variability (HRV) was calculated by autoregressive methods. Baroreflex sensitivity (BRS) was calculated by non-invasive sequence method from the recorded beat to beat blood pressure values and RR intervals. RESULTS: Significantly higher state (42.6±9.3 vs. 39.6±10.7 p=0.05) and trait (40.1±8.9 vs. 35.1±8.6, p<0.0001) anxiety scores were found in the hypertension group. There was no statistically significant difference in the depression level. LF-RRI (Low Frequency-RR interval) of HRV in passive tilt (377.3±430.6 vs. 494.1±547, p=0.049) and mean BRS slope (11.4±5.5 vs. 13.2±6.4, p=0.07) in lying position were lower in hypertensives. Trait anxiety score correlates significantly with sympatho/vagal balance (LF/HF-RRI) in passive tilt position (Spearman R=-0.286, p=0.01). CONCLUSIONS: Anxiety could play a more important role than depression in the development of hypertension. Altered autonomic control of the heart could be one of the pathophysiological links between hypertension and psychological factors.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of The Neurological Sciences. - 317 : 1-2 (2012), p. 112-116. -
További szerzők:Szekeres Csilla Cecília (1980-) (orvos) Czuriga-Kovács Katalin Réka (1981-) (neurológus) Csapó Krisztina (1979-) (neurológus) Molnár Sándor (1973-) (neurológus) Soltész Pál (1961-) (belgyógyász, kardiológus) Nyitrai Erika Magyar Mária Tünde (1970-) (neurológus) Oláh László (1967-) (neurológus) Bereczki Dániel (1960-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter)
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2.

001-es BibID:BIBFORM093908
Első szerző:Balogh Eszter (neurológus)
Cím:Effects of acute alcohol consumption on neuronal activity and cerebral vasomotor response / Balogh Eszter, Árokszállási Tamás, Körtefái Katalin, Nagy Veronika Éva, Csiba László, Oláh László
Dátum:2021
ISSN:1590-1874
Megjegyzések:Introduction In the majority of European countries, driving after drinking small-moderate amount of alcohol is legal. Motivated by our previous studies on cerebral hemodynamics, we aimed to study whether a small-moderate blood alcohol content (BAC), at which driving is legal in some countries (0.8 g/L), influences the neuronal activity, neurovascular coupling, and cerebral vasoreactivity. Methods Analyses of pattern-reversal visual evoked potential (VEP) and transcranial Doppler (TCD) examinations were performed in thirty young healthy adults before and 30 min after alcohol consumption. Cerebral vasoreactivity was evaluated by breath holding test in both middle cerebral arteries. By using a visual cortex stimulation paradigm, visually evoked flow velocity response during reading was measured in both posterior cerebral arteries (PCA). Results The BAC was 0.82 g/L and 0.94 g/L 30 and 60 min after drinking alcohol, respectively. Latency of the VEP P100 wave increased after alcohol consumption. Resting absolute flow velocity values increased, whereas pulsatility indices in the PCA decreased after alcohol ingestion, indicating vasodilation of cerebral microvessels. Breath holding index and the visually evoked maximum relative flow velocity increase in the PCA and steepness of rise of the flow velocity curve were smaller after than before alcohol consumption. Conclusion BAC close to a legal value at which driving is allowed in some European countries inhibited the neuronal activity and resulted in dilation of cerebral arterioles. Cerebral vasodilation may explain the decrease of cerebral vasoreactivity and might contribute to the disturbance of visually evoked flow response after alcohol consumption.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Acute alcohol consumption
Cerebral vasoreactivity
Neurovascular coupling
Transcranial Doppler
Visual activation
Megjelenés:Neurological Sciences. - 43 (2021), p. 625-631. -
További szerzők:Árokszállási Tamás (1988-) (neurológus) Körtefái Katalin Nagy Veronika Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
Pályázati támogatás:Nemzeti Agykutatási Program (NAP_13-1-2013-0001)
Egyéb
Nemzeti Agykutatási Program (2017-1.2.1-NKP-2017-00002)
Egyéb
GINOP-2.3.2-15-2016-00043
GINOP
MTA-DE Cerebrovascular and Neurodegenerative Research Group
MTA
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM015651
Első szerző:Czuriga-Kovács Katalin Réka (neurológus)
Cím:Cerebro- and cardiovascular reactivity and neuropsychological performance in hypertensive patients / Katalin Réka Kovács, Csilla Cecília Szekeres, Zoltán Bajkó, Krisztina Csapó, Sándor Molnár, László Oláh, Mária Tünde Magyar, Dániel Bereczki, László Kardos, Pál Soltész, Andrea Burainé Bojtor, László Csiba
Dátum:2010
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of the Neurological Sciences. - 299 : 1-2 (2010), p. 120-125. -
További szerzők:Szekeres Csilla Cecília (1980-) (orvos) Bajkó Zoltán (1970-) (neurológus) Csapó Krisztina (1979-) (neurológus) Molnár Sándor (1973-) (neurológus) Oláh László (1967-) (neurológus) Magyar Mária Tünde (1970-) (neurológus) Bereczki Dániel (1960-) (neurológus) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Soltész Pál (1961-) (belgyógyász, kardiológus) Burainé Bojtor Andrea Csiba László (1952-) (neurológus, pszichiáter)
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4.

001-es BibID:BIBFORM049332
035-os BibID:PMID:24262992
Első szerző:Szabó Katalin Judit (neurológus)
Cím:Effect of non-steroid anti-inflammatory drugs on neurovascular coupling in humans / Katalin Szabo, Bernhard Rosengarten, Tunde Juhasz, Eva Lako, Laszlo Csiba, Laszlo Olah
Dátum:2014
ISSN:0022-510X
Megjegyzések:BACKGROUND/AIMS: Neuronal activation induced cerebral blood flow increase was shown in animal experiments to require the presence of functioning cyclooxygenase. Our aim was to study whether widely used, non-steroid anti-inflammatory drugs (NSAIDs), given orally in usual therapeutic doses, inhibit neurovascular coupling in humans. METHODS: By using a visual cortex stimulation paradigm, the flow velocity response was measured by transcranial Doppler sonography in both posterior cerebral arteries of fifteen young healthy adults. The investigation was repeated in the same subjects after 2-day administration of 3x25mg indomethacin (indomethacin phase) and 2x550mg naproxen (naproxen phase). Visual-evoked-potentials were also recorded during the control phase and after administration of NSAIDs. RESULTS: Basal flow velocity significantly decreased while the pulsatility index increased after administration of either indomethacin or naproxen (p<0.01). Despite unchanged visual-evoked-potentials, the visually evoked flow velocity increase (26±7% in the control phase) significantly declined after administration of indomethacin (19±5%; p<0.01) or naproxen (20±5%; p<0.02). CONCLUSION: Oral administration of indomethacin or naproxen in their usual therapeutic doses significantly impaired the resting and the visually evoked blood flow regulations in healthy human subjects. Together with stable evoked potentials, our findings indicate disturbance of neurovascular coupling.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Cerebral blood flow
Cerebral vasoconstriction
Neurovascular coupling
Non-steroid anti-inflammatory drugs
Transcranial Doppler
Visual stimulation
Megjelenés:Journal of the Neurological Sciences. - 336 : 1-2 (2014), p. 227-231. -
További szerzők:Rosengarten, Bernhard Juhász Tünde Lakó Éva Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
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5.

001-es BibID:BIBFORM020679
Első szerző:Szabó Katalin Judit (neurológus)
Cím:Hypocapnia induced vasoconstriction significantly inhibits the neurovascular coupling in humans / Szabo K., Lako E., Juhasz T., Rosengarten B., Csiba L., Olah L.
Dátum:2011
ISSN:0022-510X
Megjegyzések:Previous studies proved that vasodilation, caused by hypercapnia or acetazolamide, does not inhibit the visually evoked flow velocity changes in the posterior cerebral arteries. Our aim was to determine whether vasoconstriction induced by hypocapnia affects the neurovascular coupling. METHODS: By using a visual cortex stimulation paradigm, visually evoked flow velocity changes were detected by transcranial Doppler sonography in both posterior cerebral arteries of fourteen young healthy adults. The control measurement was followed by the examination under hyperventilation. Visual-evoked-potentials were also recorded during the control and hyperventilation phases. RESULTS: The breathing frequency increased from 16 ± 2 to 37 ± 3/min during hyperventilation, resulting in a decrease of the end-tidal CO(2) from 37 ± 3 to 25 ± 3 mm Hg and decrease of resting peak systolic flow velocity from 58 ± 11 to 48 ± 11 cm/s (p<0.01). To allow comparisons between volunteers, relative flow velocity was calculated in relation to baseline. Repeated measures analysis of variance revealed significant difference between the relative flow velocity time courses during hyper- and normoventilation (p<0.001). The maximum changes of visually evoked relative flow velocities were 26 ± 7% and 12 ± 5% during normoventilation and hyperventilation, respectively (p<0.01). Visual-evoked-potentials did not differ in the control and hyperventilation phases. CONCLUSION: The significantly lower visually evoked flow velocity changes but preserved visual-evoked-potential during hyperventilation indicates that the hypocapnia induced vasoconstriction significantly inhibits the neuronal activity evoked flow response.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of The Neurological Sciences. - 309 : 1-2 (2011), p. 58-62. -
További szerzők:Lakó Éva Juhász Tünde Rosengarten, Bernhard Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
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6.

001-es BibID:BIBFORM065094
Első szerző:Viski Sándor Zsolt (orvos)
Cím:The acute effects of alcohol on cerebral hemodynamic changes induced by the head-up tilt test in healthy subjects / Sandor Viski, Miklos Orosz, Katalin Reka Czuriga-Kovacs, Maria Tunde Magyar, Laszlo Csiba, Laszlo Olah
Dátum:2016
ISSN:0022-510X
Megjegyzések:Background: Alcohol is a known triggering factor for orthostatic dysfunction, increasing the risk of neurally-mediated syncope. Since orthostatic tolerance may be affected by both systemic and cerebral hemodynamic changes, our aim was to investigate the acute effects of alcohol on cerebral vasoreactivity measured during the head-up tilt (HUT) test in 20 healthy subjects.Methods: Mean arterial blood pressure (mBP), heart rate, and flow parameters in both middle cerebral arteries (MCAs) were continuously recorded in the supine and during a 10-minute HUT positions before and after alcohol intake.Results: The HUT test resulted in a more prominent decline of adjusted mBP at the level of MCAs (mBPMCA) and a significantly larger decrease of MCA mean flow velocities (MFVMCA) in the post-alcohol period than before alcohol intake. During the HUT phase, the relative decrease in MFVMCA was significantly smaller than the reduction in mBPMCA before drinking alcohol, while these changes were similar after alcohol ingestion. The cerebrovascular resistance index (CVRi) decreased during the HUT phase in the control period, however, it increased after alcohol intake.Conclusion: The similar decrease inmBPMCA and MFVMCA during orthostatic stress after alcohol ingestion together with the increased CVRi indicated the impairment of the compensatory vasodilation of cerebral resistance vessels, i.e. impaired cerebral autoregulation. These findings suggest that alcohol may contribute to impaired orthostatic tolerance not only by a hypotensive response but also by the alteration of cerebral blood flow regulation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Alcohol
Orthostatic stress
Head-up tilt test
Cerebral blood flow
Cerebral autoregulation
Baroreceptor reflex
Transcranial doppler
Megjelenés:Journal Of The Neurological Sciences 368 (2016), p. 113-120. -
További szerzők:Orosz Miklós Czuriga-Kovács Katalin Réka (1981-) (neurológus) Magyar Mária Tünde (1970-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
Pályázati támogatás:NAP_13-1-2013-0001
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7.

001-es BibID:BIBFORM063682
Első szerző:Viski Sándor Zsolt (orvos)
Cím:Effect of reading on blood flow changes in the posterior cerebral artery in early blind and sighted people : a transcranial Doppler study / Sandor Viski, David Orgovan, Katalin Szabo, Bernhard Rosengarten, Laszlo Csiba, Laszlo Olah
Dátum:2016
ISSN:0022-510X
Megjegyzések:BackgroundNeuroimaging studies proved that Braille reading resulted in visual cortex activation in blind people, however, very few data are available about the measure of flow increase in these subjects. Therefore, we investigated the flow response in the posterior cerebral artery (PCA) of eleven early blind and ten sighted subjects induced by reading Braille and print, respectively.MethodsTwo experimental protocols were used in both groups: PCA flow velocity during reading was compared to the resting phase and "NLC" phase (volunteers "read" non-lexical characters; e.g. .,-.:,-.:...,). The use of these experimental protocols allowed to investigate separately the effect of "light stimulus + print reading" versus "print reading alone" in sighted, and "hand/finger movement + Braille reading" versus "Braille reading alone" in blind subjects.ResultsThe flow response in the PCA evoked by "Braille reading alone" in blind (10.5 ? 4.5%) and "print reading alone" in sighted subjects (8.1 ? 3.5%) was similar. The flow increase induced by "hand/finger movement + Braille reading" and by "Braille reading alone" did not differ in blind people, however, "light stimulus + print reading" in sighted subjects caused higher PCA flow increase (25.9 ? 6.9%) than "print reading alone" (8.1 ? 3.5%).ConclusionThe similar PCA flow response induced by Braille and print reading alone suggested a similar degree of occipital cortex activation in blind and sighted subjects. In sighted people, the 3-times higher flow velocity increase induced by "light stimulus + print reading" compared with "print reading alone" indicated that 2/3 of PCA flow increase during reading was due to the light stimulus and only 1/3 of flow response was caused by reading alone.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Cortical activation
Blind subjects
Cerebral blood flow
Neurovascular coupling
Transcranial Doppler
Megjelenés:Journal Of The Neurological Sciences 363 (2016), p. 132-139. -
További szerzők:Orgovan, David Szabó Katalin Judit (1984-) (neurológus) Rosengarten, Bernhard Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
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