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001-es BibID:BIBFORM049332
035-os BibID:PMID:24262992
Első szerző:Szabó Katalin Judit (neurológus)
Cím:Effect of non-steroid anti-inflammatory drugs on neurovascular coupling in humans / Katalin Szabo, Bernhard Rosengarten, Tunde Juhasz, Eva Lako, Laszlo Csiba, Laszlo Olah
Dátum:2014
ISSN:0022-510X
Megjegyzések:BACKGROUND/AIMS: Neuronal activation induced cerebral blood flow increase was shown in animal experiments to require the presence of functioning cyclooxygenase. Our aim was to study whether widely used, non-steroid anti-inflammatory drugs (NSAIDs), given orally in usual therapeutic doses, inhibit neurovascular coupling in humans. METHODS: By using a visual cortex stimulation paradigm, the flow velocity response was measured by transcranial Doppler sonography in both posterior cerebral arteries of fifteen young healthy adults. The investigation was repeated in the same subjects after 2-day administration of 3x25mg indomethacin (indomethacin phase) and 2x550mg naproxen (naproxen phase). Visual-evoked-potentials were also recorded during the control phase and after administration of NSAIDs. RESULTS: Basal flow velocity significantly decreased while the pulsatility index increased after administration of either indomethacin or naproxen (p<0.01). Despite unchanged visual-evoked-potentials, the visually evoked flow velocity increase (26±7% in the control phase) significantly declined after administration of indomethacin (19±5%; p<0.01) or naproxen (20±5%; p<0.02). CONCLUSION: Oral administration of indomethacin or naproxen in their usual therapeutic doses significantly impaired the resting and the visually evoked blood flow regulations in healthy human subjects. Together with stable evoked potentials, our findings indicate disturbance of neurovascular coupling.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Cerebral blood flow
Cerebral vasoconstriction
Neurovascular coupling
Non-steroid anti-inflammatory drugs
Transcranial Doppler
Visual stimulation
Megjelenés:Journal of the Neurological Sciences. - 336 : 1-2 (2014), p. 227-231. -
További szerzők:Rosengarten, Bernhard Juhász Tünde Lakó Éva Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:BIBFORM020679
Első szerző:Szabó Katalin Judit (neurológus)
Cím:Hypocapnia induced vasoconstriction significantly inhibits the neurovascular coupling in humans / Szabo K., Lako E., Juhasz T., Rosengarten B., Csiba L., Olah L.
Dátum:2011
ISSN:0022-510X
Megjegyzések:Previous studies proved that vasodilation, caused by hypercapnia or acetazolamide, does not inhibit the visually evoked flow velocity changes in the posterior cerebral arteries. Our aim was to determine whether vasoconstriction induced by hypocapnia affects the neurovascular coupling. METHODS: By using a visual cortex stimulation paradigm, visually evoked flow velocity changes were detected by transcranial Doppler sonography in both posterior cerebral arteries of fourteen young healthy adults. The control measurement was followed by the examination under hyperventilation. Visual-evoked-potentials were also recorded during the control and hyperventilation phases. RESULTS: The breathing frequency increased from 16 ± 2 to 37 ± 3/min during hyperventilation, resulting in a decrease of the end-tidal CO(2) from 37 ± 3 to 25 ± 3 mm Hg and decrease of resting peak systolic flow velocity from 58 ± 11 to 48 ± 11 cm/s (p<0.01). To allow comparisons between volunteers, relative flow velocity was calculated in relation to baseline. Repeated measures analysis of variance revealed significant difference between the relative flow velocity time courses during hyper- and normoventilation (p<0.001). The maximum changes of visually evoked relative flow velocities were 26 ± 7% and 12 ± 5% during normoventilation and hyperventilation, respectively (p<0.01). Visual-evoked-potentials did not differ in the control and hyperventilation phases. CONCLUSION: The significantly lower visually evoked flow velocity changes but preserved visual-evoked-potential during hyperventilation indicates that the hypocapnia induced vasoconstriction significantly inhibits the neuronal activity evoked flow response.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of The Neurological Sciences. - 309 : 1-2 (2011), p. 58-62. -
További szerzők:Lakó Éva Juhász Tünde Rosengarten, Bernhard Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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